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Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection’s Pathogenesis
Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection’s Pathogenesis
Integrated analysis of iron regulatory biomarkers and inflammatory response could be an important strategy for Japanese en...
MicroRNAs as a Tool for Differential Diagnosis of Neuromuscular Disorders
MicroRNAs as a Tool for Differential Diagnosis of Neuromuscular Disorders
Neuromuscular disorders (NMD) are a class of progressive disorders that are characterized by wasting of the muscles. Some ...
Author Correction: Potential of Quercetin to Protect Cadmium Induced Cognitive Deficits in Rats by Modulating NMDA‑R Mediated Downstream Signaling and PI3K/AKT—Nrf2/ARE Signaling Pathways in Hippocampus
Author Correction: Potential of Quercetin to Protect Cadmium Induced Cognitive Deficits in Rats by Modulating NMDA‑R Mediated Downstream Signaling and PI3K/AKT—Nrf2/ARE Signaling Pathways in Hippocampus
In the original version of this article, the affiliation “Academy of Scientific and Innovative Research (AcSIR), Ghaziabad...
Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice
Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice
Orexin and its receptors are closely related to the pathogenesis of Alzheimer’s disease (AD). Although the expressio...
CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
Anxiety manifestations and cognitive dysfunction are common sequelae in patients with sepsis-associated encephalopathy (SA...
Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment Among Eastern Indians
Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment Among Eastern Indians
Post-stroke cognitive impairment (PSCI) is a clinical outcome in around 30% of post-stroke survivors. BDNF is a major gene...
Fibroblast Growth Factor Receptor 2 (FGFR2), a New Gene Involved in the Genesis of Autism Spectrum Disorder
Fibroblast Growth Factor Receptor 2 (FGFR2), a New Gene Involved in the Genesis of Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a long-known complex neurodevelopmental disorder, and over the past decades, with the en...
Author Correction: Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Author Correction: Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Expression levels of activated inflammasome components, pro-inflammatory cytokine maturation and markers of cell death in ...
Neuroprotective Effects of Sinomenine on Experimental Autoimmune Encephalomyelitis via Anti-Inflammatory and Nrf2-Dependent Anti-Oxidative Stress Activity
Neuroprotective Effects of Sinomenine on Experimental Autoimmune Encephalomyelitis via Anti-Inflammatory and Nrf2-Dependent Anti-Oxidative Stress Activity
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). Sinomenine (SIN), a bio...
Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR
Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR
Medulloblastoma (MB) is a heterogeneous group of malignant pediatric brain tumors, divided into molecular groups with dist...
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
Activated microglia play dual roles in ischemic stroke (IS) according to its polarization states. Herein, we investigated ...
Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat
Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat
In individuals with chronic neuropathic pain, the posterior insular cortex (PIC) has been found to exhibit increased gluta...
The Role of Ubiquitin–Proteasome System and Mitophagy in the Pathogenesis of Parkinson's Disease
The Role of Ubiquitin–Proteasome System and Mitophagy in the Pathogenesis of Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-aged people and elderly people...
Identification of a Novel ARSA Gene Mutation Through High-Throughput Molecular Diagnosis Method in Two Girls with Late Infantile Metachromatic Leukodystrophy
Identification of a Novel ARSA Gene Mutation Through High-Throughput Molecular Diagnosis Method in Two Girls with Late Infantile Metachromatic Leukodystrophy
Metachromatic leukodystrophy (MLD) is a rare leukoencephalopathy caused by pathogenic mutations in the ARSA gene. It manif...
Dysregulated COMT Expression in Fragile X Syndrome
Dysregulated COMT Expression in Fragile X Syndrome
Transcriptional and proteomics analyses in human fragile X syndrome (FXS) neurons identified markedly reduced expression o...
Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Inflammation is a hallmark mechanism of ischemic stroke-induced brain injury. Recent studies have shown that an intracellu...
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency
AIFM1 is a mitochondrial flavoprotein involved in caspase-independent cell death and regulation of respiratory chain compl...
PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance
PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance
Glioblastoma (GBM) is the most frequent tumor of the central nervous system, and its heterogeneity is a challenge in treat...
Potential of Quercetin to Protect Cadmium Induced Cognitive Deficits in Rats by Modulating NMDA-R Mediated Downstream Signaling and PI3K/AKT—Nrf2/ARE Signaling Pathways in Hippocampus
Potential of Quercetin to Protect Cadmium Induced Cognitive Deficits in Rats by Modulating NMDA-R Mediated Downstream Signaling and PI3K/AKT—Nrf2/ARE Signaling Pathways in Hippocampus
Exposure to cadmium, a heavy metal distributed in the environment is a cause of concern due to associated health effects i...
Targeting Pericytes for Functional Recovery in Ischemic Stroke
Targeting Pericytes for Functional Recovery in Ischemic Stroke
Pericytes surrounding endothelial cells in the capillaries are emerging as an attractive cell resource, which can show a l...
Pathophysiological Links Between Obesity and Dementia
Pathophysiological Links Between Obesity and Dementia
Obesity is a major global health concern, with prevalence rates rapidly rising due to increased availability of highly pro...
Does Inflammation Play a Major Role in the Pathogenesis of Alzheimer's Disease?
Does Inflammation Play a Major Role in the Pathogenesis of Alzheimer's Disease?
Alzheimer's disease (AD) is a neurodegenerative disease leading to dementia for which no effective medicine exists. Cu...
Multiplex Analysis of Cerebrospinal Fluid and Serum Exosomes MicroRNAs of Untreated Relapsing Remitting Multiple Sclerosis (RRMS) and Proposing Noninvasive Diagnostic Biomarkers
Multiplex Analysis of Cerebrospinal Fluid and Serum Exosomes MicroRNAs of Untreated Relapsing Remitting Multiple Sclerosis (RRMS) and Proposing Noninvasive Diagnostic Biomarkers
Exosomal microRNAs (miRNAs) are emerging diagnostic biomarkers for neurodegenerative diseases. In this study, we aimed to ...
Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose
Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose
Neurodegenerative diseases and postoperative cognitive dysfunction involve the accumulation of β-amyloid peptide (A&#...
Up-Regulation of S100 Gene Family in Brain Samples of a Subgroup of Individuals with Schizophrenia: Meta-analysis
Up-Regulation of S100 Gene Family in Brain Samples of a Subgroup of Individuals with Schizophrenia: Meta-analysis
The S100 proteins family is known to affect neuroinflammation and astrocyte activation, which have been suggested to be co...
Transcriptome Analysis of the Mouse Medial Prefrontal Cortex in a Chronic Constriction Injury Model
Transcriptome Analysis of the Mouse Medial Prefrontal Cortex in a Chronic Constriction Injury Model
The medial prefrontal cortex (mPFC) is critical for both the sensory and emotional/cognitive components of pain. However, ...
Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism
Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice model is one of the most common animal models for Parkinson’...
IL-17A Facilitates Entry of Autoreactive T-Cells and Granulocytes into the CNS During EAE
IL-17A Facilitates Entry of Autoreactive T-Cells and Granulocytes into the CNS During EAE
Interleukin-17A plays a crucial role in multiple sclerosis and other autoimmune diseases. Although the link between IL-17 ...
Spautin-1 Protects Against Mild TBI-Induced Anxiety-Like Behavior in Mice via Immunologically Silent Apoptosis
Spautin-1 Protects Against Mild TBI-Induced Anxiety-Like Behavior in Mice via Immunologically Silent Apoptosis
Anxiety is reportedly one of the most common mental changes after traumatic brain injury (TBI). Perineuronal nets (PNNs) p...
The Role of PGK1 in Promoting Ischemia/Reperfusion Injury-Induced Microglial M1 Polarization and Inflammation by Regulating Glycolysis
The Role of PGK1 in Promoting Ischemia/Reperfusion Injury-Induced Microglial M1 Polarization and Inflammation by Regulating Glycolysis
Stroke is a leading cause of death, with a continuously increasing incidence. As a metabolic process that catabolizes gluc...
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