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Neural populations are dynamic but constrained
Neural populations are dynamic but constrained
Our brains evolved to help us rapidly learn new things. But anyone who has put in hours of practice to perfect their tenni...
Mapping the cellular etiology of schizophrenia and complex brain phenotypes
Mapping the cellular etiology of schizophrenia and complex brain phenotypes
Psychiatric disorders are multifactorial and effective treatments are lacking. Probable contributing factors to the challe...
α-Synuclein deposition in the kidney may contribute to Parkinson’s disease
α-Synuclein deposition in the kidney may contribute to Parkinson’s disease
During the pathogenesis of Parkinson’s disease (PD), α-synuclein pathology may originate in peripheral organs a...
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease
The pathogenesis of Lewy body diseases (LBDs), including Parkinson’s disease (PD), involves α-synuclein (α...
Retrieval of conditioned immune response in male mice is mediated by an anterior–posterior insula circuit
Retrieval of conditioned immune response in male mice is mediated by an anterior–posterior insula circuit
To protect the body from infections, the brain has evolved the ability to coordinate behavioral and immunological response...
The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow
The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow
The default mode network (DMN) is implicated in many aspects of complex thought and behavior. Here, we leverage postmortem...
Oligodendrocytes in Alzheimer’s disease pathophysiology
Oligodendrocytes in Alzheimer’s disease pathophysiology
Our understanding of Alzheimer’s disease (AD) has transformed from a purely neuronal perspective to one that acknowl...
In conversation with Ukpong Eyo
In conversation with Ukpong Eyo
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
In conversation with Kelsey Martin
In conversation with Kelsey Martin
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
Updating the striatal–pallidal wiring diagram
Updating the striatal–pallidal wiring diagram
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning and execution of flexible behav...
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairmen...
Myelin and Alzheimer’s disease
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
How we promote data sharing
In 2022, we began a pilot to facilitate data sharing for manuscripts submitted to Nature Neuroscience. Here, we analyze it...
How human brains differ
Large datasets have been generated to characterize gene expression and cell types in brain samples from many individuals, ...
Octopuses untethered
Electrophysiological studies of octopus neural activity have been hampered by the inability to anchor recording equipment ...
Sniffing for functional SNVs
Genome-wide association studies (GWAS) have identified thousands of single-nucleotide variants (SNVs) that are correlated ...
A farewell to 2023
As 2023 draws to a close, the Nature Neuroscience editors reflect on the year in neuroscience and in our pages.
Pregnant brains in parent mode
Parenthood requires substantial behavioral adaptations to ensure the well-being of offspring. Such behavior relies on vari...
This neuroprosthesis was made for walking
People with advanced Parkinson’s disease (PD) often present with locomotor deficits that do not respond to current therapi...
Author Correction: Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols
Neuroscience Institute, NYU Grossman School of Medicine, New York City, NY, USAPaul W. Frazel, Theodore Fisher, Anne March...
Discovery of a non-canonical function of SYNGAP1 at early stages of human cortical neurogenesis
Discovery of a non-canonical function of SYNGAP1 at early stages of human cortical neurogenesis
We discovered expression of SYNGAP1, which encodes the ‘synaptic’ protein SYNGAP1, within human cortical proge...
Skull bone marrow channels as immune gateways to the central nervous system
Skull bone marrow channels as immune gateways to the central nervous system
Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous c...
A brainstem circuit for phonation and volume control in mice
A brainstem circuit for phonation and volume control in mice
Mammalian vocalizations are critical for communication and are produced through the process of phonation, in which expirat...
A global multicohort study to map subcortical brain development and cognition in infancy and early childhood
A global multicohort study to map subcortical brain development and cognition in infancy and early childhood
The human brain grows quickly during infancy and early childhood, but factors influencing brain maturation in this period ...
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage
It is generally thought that under basal conditions, neurons produce ATP mainly through mitochondrial oxidative phosphoryl...
Lysosome regulation of microglia in Alzheimer’s disease via TFEB–vacuolar ATPase
Lysosome regulation of microglia in Alzheimer’s disease via TFEB–vacuolar ATPase
We show that genetic disruption of TFEB- and vacuolar ATPase-mediated lysosomal signaling leads to increased tau pathology...
Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Whole-brain genome editing to correct single-base mutations and reduce or reverse behavioral changes in animal models of a...
Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
These authors contributed equally: Zhen Zhao, Abhay P Sagare, Qingyi Ma.Zilkha Neurogenetic Institute and Department of Ph...
TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
Transcription factor EB (TFEB) mediates gene expression through binding to the coordinated lysosome expression and regulat...
Facemap: a framework for modeling neural activity based on orofacial tracking
Facemap: a framework for modeling neural activity based on orofacial tracking
Recent studies in mice have shown that orofacial behaviors drive a large fraction of neural activity across the brain. To ...
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