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Sex-specific molecular drivers of cardiac fibrosis in aging hearts
Sex-specific molecular drivers of cardiac fibrosis in aging hearts
The aging population, defined as individuals 65 years or older, is rapidly increasing, with age as the most signi...
Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan
Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan
Attentional states reflect the changing behavioral relevance of stimuli in one’s environment, having important conse...
Accelerated retinal ageing and multimorbidity in middle-aged and older adults
Accelerated retinal ageing and multimorbidity in middle-aged and older adults
The aim of this study is to investigate the association between retinal age gap and multimorbidity. Retinal age gap was ca...
Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience
Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience
A significant challenge in multi-omic geroscience research is the collection of high quality, fit-for-purpose biospecimens...
Construction and validation of a DNN-based biological age and its influencing factors in the China Kadoorie Biobank
Construction and validation of a DNN-based biological age and its influencing factors in the China Kadoorie Biobank
Biological age is an important measure of aging that reflects an individual’s physical health and is linked to vario...
Aged regulatory T cells fail to control autoimmune lacrimal gland pathogenic CD4 T cells
Aged regulatory T cells fail to control autoimmune lacrimal gland pathogenic CD4 T cells
CD25KO mice are a model of Sjögren disease. CD25KO mice have severe inflammation and infiltrating lymphocytes to the ...
Various diseases and conditions are strongly associated with the next-generation epigenetic aging clock CheekAge
Various diseases and conditions are strongly associated with the next-generation epigenetic aging clock CheekAge
Epigenetic aging clocks represent contemporary aging biomarkers that predict age using methylomic data. These models can b...
Unveiling the geroprotective potential of L.: insights from in vitro studies and a randomized clinical trial on slowing biological aging and improving quality of life
Unveiling the geroprotective potential of L.: insights from in vitro studies and a randomized clinical trial on slowing biological aging and improving quality of life
Aging is driven by fundamental mechanisms like oxidative stress, telomere shortening and changes in DNA methylation, which...
Associations between metabolomic scores and clinical outcomes in hospitalized COVID-19 patients
Associations between metabolomic scores and clinical outcomes in hospitalized COVID-19 patients
The disease course and outcome of COVID-19 greatly varies between individuals. To explore which biological systems may con...
Examining the test–retest reliability of commonly used neuromuscular, morphological, and functional measures in aging adults
Examining the test–retest reliability of commonly used neuromuscular, morphological, and functional measures in aging adults
The present study aimed at determining the test–retest reliability of commonly used measures in a sample of middle-a...
Associations between environmental air pollution, greenspace and apparent biological aging: a cross-sectional study
Associations between environmental air pollution, greenspace and apparent biological aging: a cross-sectional study
Aging is a driving factor of various non-communicable diseases. Air pollution and greenspace also affect human health to v...
Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality
Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality
The link between abnormal sleep duration and stroke outcomes remains contentious. This meta-analysis quantifies how both s...
Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis
Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis
Sleep duration is a crucial factor influencing health outcomes, yet its relationship with mortality remains debated. In th...
Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice
Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice
Transient receptor potential ankyrin 1 (TRPA1) is a sensory channel expressed in vagal afferent nerves that detect noxious...
Automated abdominal aortic calcification scoring from vertebral fracture assessment images and fall-associated hospitalisations: the Manitoba Bone Mineral Density Registry
Automated abdominal aortic calcification scoring from vertebral fracture assessment images and fall-associated hospitalisations: the Manitoba Bone Mineral Density Registry
Abdominal aortic calcification (AAC), a subclinical measure of cardiovascular disease (CVD) that can be assessed on verteb...
Polypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approach
Polypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approach
Polypharmacy is common among older adults and has been linked to adverse outcomes such as dementia, Parkinson’s dise...
Topoisomerase inhibitor amonafide enhances defense responses to promote longevity in
Topoisomerase inhibitor amonafide enhances defense responses to promote longevity in
Aging is a major risk factor for disease, and developing effective pharmaceutical interventions to improve healthspan and ...
Proteomic and phosphoproteomic signatures of aging mouse liver
Proteomic and phosphoproteomic signatures of aging mouse liver
The liver is a metabolic powerhouse, crucial for regulating carbohydrates, fats, and protein metabolism. In this study, we...
The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease
The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease
Despite the fact that more than 90% of tryptophan is metabolized via the kynurenine pathway, the serotonin pathway is of g...
Role of BKCa Channels in Pial-Vessel Dilation in Rats of Different Ages
Role of BKCa Channels in Pial-Vessel Dilation in Rats of Different Ages
Studying the mechanisms of age-related changes in vascular reactions and applying the acquired knowledge in clinics can he...
Should We Consider Water and Antibiotics to Be Geroprotectors?
Should We Consider Water and Antibiotics to Be Geroprotectors?
The authors try to consider the current situation with experimental gerontological research aimed at finding means to slow...
Larval Heat Stress Affects the Lifespan and Stress Resistance of Drosophila melanogaster Adults
Larval Heat Stress Affects the Lifespan and Stress Resistance of Drosophila melanogaster Adults
In modern conditions of constant adverse effects on living organisms, such as environmental pollution or global climate ch...
On the Concentration of Vitamins A and E in the Tissues of the Bank Vole (Myodes (Clethrionomys) glareolus) and Common Shrew (Sorex araneus) Inhabiting Karelia
On the Concentration of Vitamins A and E in the Tissues of the Bank Vole (Myodes (Clethrionomys) glareolus) and Common Shrew (Sorex araneus) Inhabiting Karelia
We have studied the concentration of vitamins A (retinol) and E (α-tocopherol) in the tissues of the bank vole (Myode...
Effects of Time-of-Day on the Expression of Autophagy Genes at the Different Stages of Age-Related Macular Degeneration-Like Retinopathy in Rat’s Retina
Effects of Time-of-Day on the Expression of Autophagy Genes at the Different Stages of Age-Related Macular Degeneration-Like Retinopathy in Rat’s Retina
Age-related macular degeneration (AMD) is a complex progressive eye disease, resulting in loss of central vision in the ag...
Validation of the Portuguese Version of the Adult Carers Quality of Life Questionnaire (AC-QoL) among Informal Carers of Stroke Survivors
Validation of the Portuguese Version of the Adult Carers Quality of Life Questionnaire (AC-QoL) among Informal Carers of Stroke Survivors
Stroke is a leading cause of disability worldwide, significantly affecting not only the health and quality of life of surv...
Peculiar Relations of Life Expectancy with Economics according to the Preston Curve and with Cultural Values according to the Hofstede Dimensions in Former Soviet Union and Yugoslavia Countries
Peculiar Relations of Life Expectancy with Economics according to the Preston Curve and with Cultural Values according to the Hofstede Dimensions in Former Soviet Union and Yugoslavia Countries
We checked whether national cultural differences according to Hofstede dimensions (HD) contribute to differences in life e...
Multiple Sclerosis. Some Features of Pathology and Prospects for Therapy. Part 1
Multiple Sclerosis. Some Features of Pathology and Prospects for Therapy. Part 1
Multiple sclerosis (MS) is among the most common diseases of the central nervous system. The disease leads to pathological...
Association of Prior Antithrombotic Drug Use with 90-Day Mortality After Intracerebral Hemorrhage
Association of Prior Antithrombotic Drug Use with 90-Day Mortality After Intracerebral Hemorrhage
Estimating the strength of association between use of antithrombotics drugs with survival after spontaneous intracerebral ...
The Western Denmark Myocardial Perfusion Imaging Registry: A Review and Validation Study
The Western Denmark Myocardial Perfusion Imaging Registry: A Review and Validation Study
To review the content, quality, and research potential of the WDHR-MPI and assess the completeness and validity of its key...
Cardiovascular Data Quality in the Danish National Patient Registry (1977–2024): A Systematic Review
Cardiovascular Data Quality in the Danish National Patient Registry (1977–2024): A Systematic Review
Providing an overview and examine determinants of the cardiovascular data quality in the Danish National Patient Registry ...
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