SCI Abstract

search
+
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
An increasing number of traditional Chinese medicine(TCM) have been confirmed to possess analgesic bioactivity. 701 Dieda ...
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Increasing evidence indicated that purinergic signalling involved in electroacupuncture (EA)-induced analgesia. Whether pu...
Mechanosensitive release of ATP in the urinary bladder mucosa
Mechanosensitive release of ATP in the urinary bladder mucosa
The urinary bladder mucosa (urothelium and suburothelium/lamina propria) functions as a barrier between the content of the...
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
Our previous work had identified that at the acupuncture point (acupoint), acupuncture-induced ATP release was a pivotal e...
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
The P2X7 receptor, an ATP-gated ion channel which belongs to the P2X receptor family, plays critical roles in recognizing ...
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury
Purinergic signaling plays a role in the pathophysiology of different viral infections. Recently, we showed that COVID-19 ...
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk
Purines are important mediators of intercellular communication in the enteric nervous system (ENS) that participate in phy...
Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist
Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist
P2X4 receptors are ATP-gated cation channels that were proposed as novel drug targets due to their role in inflammation an...
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
The P2Y6 receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative,...
Purinergic regulation of pulmonary vascular tone
Purinergic regulation of pulmonary vascular tone
Purinergic signaling is a crucial determinant in the regulation of pulmonary vascular physiology and presents a promising ...
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools
There is growing interest in the P2X4 receptor as a therapeutic target for several cardiovascular, inflammatory and neurol...
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes
Intestinal low-grade inflammation induced by a high-fat diet has been found to detonate chronic systemic inflammation, whi...
Cutaneous melanoma and purinergic modulation by phenolic compounds
Cutaneous melanoma and purinergic modulation by phenolic compounds
Cutaneous melanoma is a complex pathology that still has only treatments that lack efficiency and offer many adverse effec...
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets
Cervical cancer ranks as the fourth most common and fatal cancer among women worldwide. Studies have demonstrated a strong...
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR
One of the leading causes of cancer-related deaths worldwide is colorectal cancer (CRC). Extracellular ATP (e-ATP) and pur...
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
P2X7 receptors (P2X7Rs) are membrane-bound ATP-gated ion channels that are composed of three subunits. Different subunit s...
Purinergic signaling in the battlefield of viral infections
Purinergic signaling in the battlefield of viral infections
Purinergic signaling has been associated with immune defenses against pathogens such as bacteria, protozoa, fungi, and vir...
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis
Leishmania braziliensis is a pathogenic protozoan parasite that causes American Tegumentary Leishmaniasis (ATL), an import...
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing
Inflammatory pain, sustained by a complex network of inflammatory mediators, is a severe and persistent illness affecting ...
Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors
Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors
Adenosine receptor (AR) suppresses inflammation and fibrosis by activating cyclic adenosine monophosphate (cAMP) signaling...
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)
Trypanosoma cruzi is the pathogen of Chagas disease, a neglected tropical disease that affects more than 6 million people ...
Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme
Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme
Bladder cancer (BC) is the most common cancer of the urinary tract. Bozepinib (BZP), a purine-derived molecule, is a poten...
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway
This study was designed to investigate the potential of extracellular adenosine 5′-triphosphate (ATP) via the P2R...
Purinergic system in cancer stem cells
Purinergic system in cancer stem cells
Accumulating evidence supports the idea that cancer stem cells (CSCs) are those with the capacity to initiate tumors, gene...
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation
Diabetic neuropathic pain (DNP) is a common and destructive complication of diabetes mellitus. The discovery of effective ...
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation
Nucleosides and purine nucleotides serve as transmitter and modulator agents that extend their functions beyond the cell. ...
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden
The P2X7 receptor (P2X7R) stands out within the purinergic family as it has exclusive pharmacological and regulatory featu...
Coffee, adenosine, and the liver
Coffee, adenosine, and the liver
A variety of observational studies have demonstrated that coffee, likely acting through caffeine, improves health outcomes...
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells
We aimed to evaluate the effect of caffeine on viability, apoptosis, migration, redox profile and modulatory effect of the...
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells
Department of Medical and Oral Sciences and Biotechnologies, “G.d’Annunzio” University of Chieti-Pescara, Chieti, ItalyMar...
Load More
format_indent_increase