SCI Abstract

search
+
Optogenetic engineering for ion channel modulation
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 921db...
Lipid probes to study ion channels
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 921db...
Stimuli-responsive synthetic ionophores for therapeutic applications
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 921db...
Illuminating antifungal mode of action and resistance with fluorescent probes
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 921db...
Recent advances in high-throughput screening methods for small molecule modulators in bacteria
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 921db...
Corrigendum to “Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling” Curr Opin Chem Biol 84 (2025) 102564
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 921db...
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 921db...
Structural basis of circularly permuted group II intron self-splicing
Structural basis of circularly permuted group II intron self-splicing
Circularly permuted group II introns (CP introns) consist of rearranged structural domains separated by two tethered exons...
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Multiple allosteric mechanisms suppress PRC2 activity at active genes
Multiple allosteric mechanisms suppress PRC2 activity at active genes
PRC2-dependent H3K27 methylation must be excluded from active genes to support appropriate transcriptional programs. Struc...
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)
Protein glycosylation regulates essential cellular processes such as signaling, adhesion and cell–cell interactions;...
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase
Misfolded glycoproteins in the endoplasmic reticulum (ER) lumen are translocated into the cytosol and degraded by the prot...
Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition
Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition
Metazoan gene transcription by RNA polymerase II (Pol II) is regulated in the promoter-proximal region. Pol II can undergo...
An in vivo platform to screen for regulators of Huntington’s disease
Repeat-expansion diseases, such as Huntington’s disease, often cause detrimental neurodegenerative phenotypes and can be i...
Personalized medicine for cancer cachexia via the ghrelin receptor
Personalized medicine for cancer cachexia via the ghrelin receptor
The ghrelin receptor (GHSR1a) is a key target for treating cancer cachexia. A study now reveals the structure of the GHSR1...
Indoleamine 2, 3-dioxygenase Regulates the Differentiation of T Lymphocytes to Promote the Growth of Gastric Cancer Cells through the PI3K/Akt/mTOR Pathway
Indoleamine 2, 3-dioxygenase Regulates the Differentiation of T Lymphocytes to Promote the Growth of Gastric Cancer Cells through the PI3K/Akt/mTOR Pathway
To investigate the regulatory mechanism of indoleamine 2, 3-dioxygenase (IDO) in T lymphocyte differentiation and its role...
Caffeic Acid Phenethyl Ester Enhances Bone Repair-related Factors in MC3T3-E1 Cells
Caffeic Acid Phenethyl Ester Enhances Bone Repair-related Factors in MC3T3-E1 Cells
Apical periodontitis is an inflammatory disease caused by bacterial infection in the root canal that spreads to the apical...
Berberine and Cyperus rotundus extract nanoformulations protect the rats against Staphylococcus-induced mastitis via antioxidant and anti-inflammatory activities: role of MAPK signaling
Berberine and Cyperus rotundus extract nanoformulations protect the rats against Staphylococcus-induced mastitis via antioxidant and anti-inflammatory activities: role of MAPK signaling
Berberine (BER) and Cyperus rotundus rhizomes extract (CRE) are phytochemicals characterized by broad-spectrum pharmacolog...
Apatinib Mesylate Inhibits Cell Proliferation and the Metastasis of Esophageal Squamous Cell Carcinoma Through ERK/ELK-1/Snail Pathway
Apatinib Mesylate Inhibits Cell Proliferation and the Metastasis of Esophageal Squamous Cell Carcinoma Through ERK/ELK-1/Snail Pathway
This study aimed to evaluate the impact of apatinib (APT) mesylate on the growth, migration ability, and underlying mechan...
Evaluating the Synergistic Antioxidant, Anti-microbial and Adsorbent Potential of Andrographis Paniculata Extract and Gold Nanoparticles
Evaluating the Synergistic Antioxidant, Anti-microbial and Adsorbent Potential of Andrographis Paniculata Extract and Gold Nanoparticles
The present study introduces a minimalistic and cost-effective approach to synthesising Gold nanoparticles (AuNPs) using a...
The Activation of the CCND1 Promoter by AP-1 and SOX Transcription Factors in PC3 Prostate Cancer Cells Can Be Prevented by Anacardic Acid Analogs
The Activation of the CCND1 Promoter by AP-1 and SOX Transcription Factors in PC3 Prostate Cancer Cells Can Be Prevented by Anacardic Acid Analogs
Targeting more than one in nine men before age 70, prostate cancer is the most common type of cancer in men. The increased...
Expression of Elastin, F-Box and WD-40 Domain-Containing Protein 2, Fibrillin-1, and Alpha-Smooth Muscle Actin in Utilized Blood Vessels for explant culture—A New 3D in Vitro Vascular Model from Bovine Legs
Expression of Elastin, F-Box and WD-40 Domain-Containing Protein 2, Fibrillin-1, and Alpha-Smooth Muscle Actin in Utilized Blood Vessels for explant culture—A New 3D in Vitro Vascular Model from Bovine Legs
Elastic fibers of the internal and external elastic laminae maintain blood vessel shapes. Impairment of smooth muscle cell...
Interaction Between Allopregnanolone and Amiloride Binding Sites on the GABAA Receptor
Interaction Between Allopregnanolone and Amiloride Binding Sites on the GABAA Receptor
Allopregnanolone (Allo) is a positive allosteric modulator of the GABAA receptor, and amiloride (Ami) is a competitive ant...
Suppression of FcεRI-evoked Degranulation in RBL-2H3 Cells on Gelatin Methacryloyl Hydrogel
Suppression of FcεRI-evoked Degranulation in RBL-2H3 Cells on Gelatin Methacryloyl Hydrogel
Cell–extracellular matrix (ECM) interactions play multiple roles in developmental, physiological, and pathological p...
Sudachitin Reduces Inflammatory Mediator Expression in Toll-Like Receptor 2 Ligand-Stimulated Human Dental Pulp Cells
Sudachitin Reduces Inflammatory Mediator Expression in Toll-Like Receptor 2 Ligand-Stimulated Human Dental Pulp Cells
Sudachitin, which is a polymethoxy flavonoid derived from the peer of Citrus sudachi, has several biological properties. H...
Cardioprotective Potential of d-limonene against Isoproterenol induced Myocardial Infarction in Rats
Cardioprotective Potential of d-limonene against Isoproterenol induced Myocardial Infarction in Rats
d-limonene is a type of colorless liquid hydrocarbon that falls under the category of cyclic monoterpene. It is the compon...
IRF7 Activates LCN2 Transcription to Enhance LPS-Induced Acute Lung Injury by Inducing Macrophage Ferroptosis and M1 Polarization
IRF7 Activates LCN2 Transcription to Enhance LPS-Induced Acute Lung Injury by Inducing Macrophage Ferroptosis and M1 Polarization
Acute lung injury (ALI), a severe pulmonary disorder that poses a significant threat to life, is closely associated with m...
Mechanistic Insights into Silymarin-Induced Apoptosis and Growth Inhibition in SPC212 Human Mesothelioma Cells
Mechanistic Insights into Silymarin-Induced Apoptosis and Growth Inhibition in SPC212 Human Mesothelioma Cells
Silymarin, a flavonoid complex isolated from Silybum marianum, possesses various biological properties, including antioxid...
Water-Soluble Ginseng Oligosaccharides Prevent Scopolamine-Induced Cholinergic Dysfunction and Inflammatory Cytokine Overexpression
Water-Soluble Ginseng Oligosaccharides Prevent Scopolamine-Induced Cholinergic Dysfunction and Inflammatory Cytokine Overexpression
Cholinergic deficiency and neuroinflammation are the two main factors of Alzheimer’s disease. Recent studies have sh...
Acacetin Attenuates Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury by Activating NRF2/SLC7A11/GPX4 Signaling to Inhibit Ferroptosis
Acacetin Attenuates Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury by Activating NRF2/SLC7A11/GPX4 Signaling to Inhibit Ferroptosis
Chronic obstructive pulmonary disease (COPD) stands as a major contributor to mortality worldwide, with cigarette smoke be...
Load More
format_indent_increase