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Increased nuclear import characterizes aberrant nucleocytoplasmic transport in neurons from patients with spinocerebellar ataxia type 7
1 Introduction Spinocerebellar ataxia type 7 (SCA7) is a hereditary autosomal dominant neurodegenerative disorder charac...
The good, the bad, and the unknown nature of decreased GD3 synthase expression
1 Introduction Gangliosides, complex glycosphingolipids, challenging to investigate with common molecular biology method...
Editorial: Regulators of synapse formation: understanding the molecular mechanisms and its dysregulation in neurodevelopmental disorders
and behavioral functions. This research topic comprises six articles that explore the latest discoveries in the molecular ...
Perinuclear compartment controls calcineurin/MEF2 signaling for axonal outgrowth of hippocampal neurons
1 Introduction A unique and fundamental characteristic of the nervous system during development is the ability of neuron...
Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors
Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors
Introduction The intracellular messengers, cyclic AMP (cAMP) and cyclic GMP (cGMP), are involved in the mechanisms of sy...
Editorial: Antiviral drugs: neurotoxicity and neurodevelopmental effects
Several anti-viral drugs like those used to treat human immunodeficiency virus (HIV) infections have been associated with ...
Effect of histone demethylase KDM5B on long-term cognitive impairment in neonatal rats induced by sevoflurane
1 Introduction Sevoflurane is an anesthetic widely used in pediatric general anesthesia, whether it is safe to applicati...
Toll-like receptors as a missing link in Notch signaling cascade during neurodevelopment
1 Notch and Toll—structural and signaling features During neurodevelopment, neural progenitor cells (NPCs) settled in th...
TMAO is involved in sleep deprivation-induced cognitive dysfunction through regulating astrocytic cholesterol metabolism via SREBP2
1 Introduction Sleep loss appears common daily and has become a global public health issue. According to the World Healt...
Cell-autonomous action of Slit2 in radial migration of cortical projection neurons
Introduction The cerebral cortex is a highly ordered brain structure with neurons organized into six distinct layers. Th...
Corrigendum: Mechanisms of mitophagy and oxidative stress in cerebral ischemia–reperfusion, vascular dementia, and Alzheimer's disease
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Differential timing of mitochondrial activation in rat dorsal striatum induced by procedural learning and swimming
1 Introduction Aversive learning experiences are associated with the activation of the hypothalamic-pituitary-adrenal axi...
Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy
1 Introduction Copper (Cu) is an essential element involved in a plethora of metabolic processes through its structural,...
Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration
Introduction Retinal degeneration is a major cause of irreversible blindness. It is projected that the incidence of reti...
Calcium-sensor proteins but not bicarbonate ion activate retinal photoreceptor membrane guanylyl cyclase in photoreceptors
Introduction Vertebrate rods and cones respond to light by changing the permeability of cyclic nucleotide-gated cation c...
Development of KCC2 therapeutics to treat neurological disorders
Introduction The KCC2 transporter is the CNS neuron-specific Cl– extruder essential for the establishment and maintenance...
Chaperones vs. oxidative stress in the pathobiology of ischemic stroke
1 Introduction The global burden inflicted by ischemic stroke is dramatic: the annual number of new cases [7,630,803 in 2...
Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice
Introduction Prion diseases are fatal and intractable neurodegenerative disorders affecting both animals and humans, inc...
VNS paired with training enhances recognition memory: mechanistic insights from proteomic analysis of the hippocampal synapse
1 Introduction Recognition memory is a fundamental component of cognitive health, allowing us to learn and remember new ...
A sex-specific effect of M4 muscarinic cholinergic autoreceptor deletion on locomotor stimulation by cocaine and scopolamine
1 Introduction Acetylcholine regulates numerous critical functions within the basal ganglia by activating nicotinic and m...
Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
Combined antiretroviral therapy (cART) has greatly decreased mortality and morbidity among persons with HIV; however, neur...
DNMT1 downregulation as well as its overexpression distinctly affect mostly overlapping genes implicated in schizophrenia, autism spectrum, epilepsy, and bipolar disorders
DNMT1 downregulation as well as its overexpression distinctly affect mostly overlapping genes implicated in schizophrenia, autism spectrum, epilepsy, and bipolar disorders
Data on schizophrenia (SZ), epilepsy (EPD) and bipolar disorders (BPD) suggested an association of DNMT1 overexpression wh...
Corrigendum: Role of α2δ-3 in regulating calcium channel localization at presynaptic active zones during homeostatic plasticity
Corrigendum: Role of α2δ-3 in regulating calcium channel localization at presynaptic active zones during homeostatic plasticity
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Exosomal microRNAs: implications in the pathogenesis and clinical applications of subarachnoid hemorrhage
Exosomal microRNAs: implications in the pathogenesis and clinical applications of subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a severe acute neurological disorder with a high fatality rate. Early brain injury (EBI) ...
Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis
Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis
Adult neurogenesis is a persistent phenomenon in mammals that occurs in select brain structures in both healthy and diseas...
Editorial: Molecular signalling and pathways contributing to neurodevelopmental disorders: insights into potential therapeutic avenues
Editorial: Molecular signalling and pathways contributing to neurodevelopmental disorders: insights into potential therapeutic avenues
Over the last decade, there has been growing interest and important developments in the understanding of mechanisms involv...
Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord
Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord
The superficial dorsal horn (SDH) of the spinal cord contains a diverse array of neurons. The vast majority of these are i...
Spinal GABA transporter 1 contributes to evoked-pain related behavior but not resting pain after incision injury
Spinal GABA transporter 1 contributes to evoked-pain related behavior but not resting pain after incision injury
The inhibitory function of GABA at the spinal level and its central modulation in the brain are essential for pain percept...
Editorial: RNA binding proteins in neuroscience
Editorial: RNA binding proteins in neuroscience
Unraveling the complexities of brain function relies on the precise coordination of gene expression in different neural su...
It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease
It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease
The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in ...
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