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How pathogens drive adipose tissue loss in the host
Weight loss is a hallmark of many infections, including those caused by bacteria, fungi and parasites. This loss is often ...
Immune evasion runs in the family: two surface protein families of Plasmodium falciparum–infected erythrocytes
Two protein families are found on the surfaces of erythrocytes infected with Plasmodium falciparum, a causative agent of d...
Moving beyond discovery science to a mechanistic understanding of human malaria
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
The role of microbial succinate in the pathophysiology of inflammatory bowel disease: mechanisms and therapeutic potential
Inflammatory bowel disease (IBD) is a chronic, immune-mediated condition characterized by inflammation of the gastrointest...
Pathogen adaptation to lung metabolites
Upon invading mucosal tissues such as the lung, opportunistic pathogens must rapidly adapt to locally available carbon sou...
Long-chain fatty acids as nutrients for Gram-negative bacteria: stress, proliferation, and virulence
Fatty acids, carboxylic acids with a saturated or unsaturated aliphatic chain, are classified as short- (<6 carbons), m...
Dividing lines: compartmentalisation and division in Streptomyces
Bacteria display diverse strategies for cell division, exemplified by the multicellular life cycle of Streptomyces, a genu...
Organizing organelles: bacterial strategies for localizing intracellular compartments
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Cell cycle regulation in Escherichia coli: from governing principles, checkpoints, and control variables to molecular mechanisms
All cells share the basic challenge of integrating the various processes that ensure their faithful replication. In most b...
Immunometabolism shapes chronic Staphylococcus aureus infection: insights from biofilm infection models
Staphylococcus aureus is a commensal organism that colonizes the skin, nasal passages, and other body sites of approximate...
A solution to the postantibiotic era: phages as precision medicine
With the threat of a postantibiotic era looming, there is great interest in developing new therapeutics to take their plac...
The importance of persistence and dormancy in Trypanosoma cruzi infection and Chagas disease
T. cruzi is a kinetoplastid protozoan and the causative agent of Chagas disease. Despite the restriction of the insect-vec...
Skin models for studying vector-borne kinetoplastid infections
Kinetoplastid infections, caused by Leishmania and Trypanosoma species, pose significant global health challenges, disprop...
Encapsulins: catalysis inside a shell
Internal cellular organization is a defining feature of life, and encapsulins are an effective, protein-based method for p...
A tale of two nitrous oxide reductases: a cautionary perspective
Volume 86, August 2025, 102631Author links open overlay panel, , Highlights•N2O reductases, encoded by nosZ, are phylogene...
Exome analyses unravel the genetic architecture of Mendelian dominant nonsyndromic orofacial clefts
Nonsyndromic orofacial clefts (NSOFC) represents a prevalent congenital anomalies, the etiology of which likely involves a...
Identification of potential modulators of intrauterine adhesion pathogenesis with RNA sequencing, histology and in vitro assays
Intrauterine adhesion (IUA), also referred to as intrauterine stenosis or synechiae, is a prevalent gynecological issue, w...
Molecular insights into temperature-driven color variation in Stropharia rugosoannulata mushrooms
The data generated for the current study was submitted to the public domain. Current study data is available on NCBI platf...
16S rDNA sequencing reveal synergistic effects of silkworm feces and earthworms on nutrient-poor soil microbial community structure and function in Guangxi
Author links open overlay panel, , , , , Highlights•Silkworm feces and earthworms synergistically enhance soil microbial d...
Comprehensive expression genome-wide association study of long non-coding RNAs in four porcine tissues
BackgroundLong non-coding RNAs (lncRNAs), a type of non-coding RNA molecules, are known to play critical regulatory roles ...
Identification of blacklist regions in cattle and pig genomes
Cattle and pigs are important farm animals and biomedical models for studying human development and diseases. Accurate ann...
Gap-free genome assembly and comparative analysis reveal the evolution and lignin degradation mechanisms of Cylindrobasidium torrendii
The Physalacriaceae family comprises numerous saprophytic edible and medicinal fungi with significant ecological and econo...
Integrated analysis of single-cell and bulk RNA sequencing identifies APOC1 as a biomarker and therapeutic target for G0/G1 cell cycle arrest in cholangiocarcinoma
Cholangiocarcinoma is characterized by its high malignancy, frequent recurrence and insensitivity to conventional radiothe...
Genomic insights and phylogenetics of the mitochondrial genome of Cryptocarya
The tropical genus Cryptocarya is known for its valuable timber and the constituents in these trees show potential for med...
METTL14 facilitates the process of sexual reversal via m6A RNA methylation in Pelodiscus sinensis
The Chinese soft-shelled turtle (Pelodiscus sinensis, P. sinensis) demonstrates noteworthy sexual dimorphism, where the ma...
Integrated analysis of lipid metabolism and differentially expressed genes reveal seed oil accumulation in field muskmelon
Field muskmelon (Cucumis melo L. var. agrestis Naud.), a novel oil crop, contains a high amount of lipids in seeds. Howeve...
Deep sequencing of Korean Jindo dog reveals evolutionary trajectory of coat color variations
The inherent diversity of canines is closely intertwined with the unique color patterns of each dog population. These vari...
Transcriptome and metabolome reveal the mechanism of neuroendocrine regulation in ovarian development of broiler breeders
The long-term selection for meat has led to the poor egg production efficiency in broiler. In this study, we analyzed the ...
Transcriptome analysis reveals that the injection of mesenchymal stem cells remodels extracellular matrix and complement components of the brain through PI3K/AKT/FOXO1 signaling pathway in a neuroinflammation mouse model
Author links open overlay panel, , , , , , , Highlights•The brains of mice that received injections of LPS and MSCs were s...
Insights for variant clinical interpretation based on a benchmark of 65 variant effect predictors
Single amino acid substitutions in protein sequences are generally harmless, but a certain number of these changes can lea...
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