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Prenatal Ruxolitinib Treatment Improved Muscle Strength but Showed No Impact on the Neurobehavioral and Electrophysiological Traits in Adult Mice
Prenatal Ruxolitinib Treatment Improved Muscle Strength but Showed No Impact on the Neurobehavioral and Electrophysiological Traits in Adult Mice
The JAK/STAT signalling pathway is essential for cell communication and gene expression, particularly in brain development...
Noscapine Down-Regulates LPS-Induced Neuroinflammation in BV-2 Microglia Cells via Modulation of MAPK and NF-κB Signaling Pathways
Noscapine Down-Regulates LPS-Induced Neuroinflammation in BV-2 Microglia Cells via Modulation of MAPK and NF-κB Signaling Pathways
Noscapine is widely used to prevent stroke, glioblastoma, and anxiety. The aim of this study was to investigate the anti-n...
Clinical Value of lncRNA MALAT1 and miR-154-5p in the Severity and Prognosis of Convulsive Status Epilepticus
Clinical Value of lncRNA MALAT1 and miR-154-5p in the Severity and Prognosis of Convulsive Status Epilepticus
Convulsive status epilepticus (CSE) is a common pediatric emergency that can lead to irreversible brain damage and high mo...
Establishment of Neurofilament Light Chain in Plasma-Derived Neuronal Extracellular Vesicles as a Biomarker for Disease Progression in Multiple Sclerosis Patients
Establishment of Neurofilament Light Chain in Plasma-Derived Neuronal Extracellular Vesicles as a Biomarker for Disease Progression in Multiple Sclerosis Patients
Multiple sclerosis (MS) is a complex neurological disorder. Neurofilament light chain (NfL) is a marker of axonal injury. ...
S100B, GFAP and NSE: The Role of Neuro Biomarkers for Early Predictors of Cerebral Vaso-Occlusive Manifestations of Sickle Cell Disease
S100B, GFAP and NSE: The Role of Neuro Biomarkers for Early Predictors of Cerebral Vaso-Occlusive Manifestations of Sickle Cell Disease
Hemoglobinopathies are commonly occurring genetic disorders worldwide. The aim of this study is to determine the biochemic...
Evaluation of the Low-Energy Ultrashort Pulsed Electron Beam Irradiation-Induced Oxidative Stress and Adaptive Response of Select Enzymes in a Rat Brain
Evaluation of the Low-Energy Ultrashort Pulsed Electron Beam Irradiation-Induced Oxidative Stress and Adaptive Response of Select Enzymes in a Rat Brain
The aim of this study is to evaluate the dynamics of oxidative stress (OS) development, as well as adaptive response of se...
Exploring Mitochondrial Quality in Aging and Neurodegenerative Diseases
Exploring Mitochondrial Quality in Aging and Neurodegenerative Diseases
Aging is a gradual process characterized by a decline in cellular and tissue function, significantly contributing to the d...
The Correlation between NLR and PLR and the Occurrence and Prognosis of PHI in Patients with Traumatic Brain Injury
The Correlation between NLR and PLR and the Occurrence and Prognosis of PHI in Patients with Traumatic Brain Injury
The purpose of this retrospective study was to investigate the risk factors associated with progressive hemorrhagic injury...
Possible Mechanism for Perception of Auditory-Verbal Hallucinations in Schizophrenia and Approaches to Their Weakening
Possible Mechanism for Perception of Auditory-Verbal Hallucinations in Schizophrenia and Approaches to Their Weakening
We put forward a hypothesis that the processing and perception of auditory-verbal hallucinations in schizophrenia such as ...
A Systematic Review on the Effectiveness of Trigonelline, Safranal and Chamomile in Cure and Prevention of Alzheimer’s Disease and Dementia
A Systematic Review on the Effectiveness of Trigonelline, Safranal and Chamomile in Cure and Prevention of Alzheimer’s Disease and Dementia
Alzheimer’s disease and dementia are neurodegenerative conditions characterized by memory loss and diminished capaci...
Exploring the Role of TRP Channels and Neurotrophic Factors in Epileptogenesis: Insights from Diverse Seizure Models
Exploring the Role of TRP Channels and Neurotrophic Factors in Epileptogenesis: Insights from Diverse Seizure Models
Epilepsy affects many people globally and results from disrupted neuron balance, causing abnormal central nervous system e...
miR-92b-3p Regulates Cell Progression and Drug Resistance through Upregulation of CXCL5 in Glioma
miR-92b-3p Regulates Cell Progression and Drug Resistance through Upregulation of CXCL5 in Glioma
As malignant central nervous system tumors, glioma have strong aggressiveness and drug resistance, which reduces the survi...
Comparison of Methods for Isolation of Extracellular Vesicles from Human Serum
Comparison of Methods for Isolation of Extracellular Vesicles from Human Serum
Extracellular vesicles (EVs) have recently become an important object of studies. It seems that, in the body, intercellula...
Regulation of miR-590-5p on Neurological Inflammation and Oxidative Stress and Its Biomarker Role in Parkinson’s Disease
Regulation of miR-590-5p on Neurological Inflammation and Oxidative Stress and Its Biomarker Role in Parkinson’s Disease
Parkinson’s disease (PD) is a common neurological degradation disease involving inflammation and oxidative stress. A...
Impact of Intensive Insulin Therapy on Clinical Outcomes of Traumatic Brain Injury Patients with Pre-Existing Diabetes
Impact of Intensive Insulin Therapy on Clinical Outcomes of Traumatic Brain Injury Patients with Pre-Existing Diabetes
To determine the effect of intensive insulin therapy on blood glucose control in diabetes patients with traumatic brain in...
Brain Mechanisms Involved in Post COVID Syndrome: A Narrative Review
Brain Mechanisms Involved in Post COVID Syndrome: A Narrative Review
Potentially, patients with COVID-19 can experience long-term disturbances after the acute infection period, even people wi...
Xingnaojing Combined with Brain Glycoside Peptide Targets LncRNA-H19 and Regulates hsa-microRNA (miR)-138-5p/MAPK6 to Alleviate Acute Ischemic Stroke
Xingnaojing Combined with Brain Glycoside Peptide Targets LncRNA-H19 and Regulates hsa-microRNA (miR)-138-5p/MAPK6 to Alleviate Acute Ischemic Stroke
This study aimed to explore the efficacy of Xingnaojing combined with brain glycoside peptide (XCGP) in the treatment and ...
Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies
Features of Changes in Exogenous Heat Shock Proteins (HSP 27 and HSP 70) in Patients with Occupational Nervous System Pathologies
Abstract—The aim of this study was to identify and compare changes in serum concentrations of heat shock proteins (H...
The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain
The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain
Abstract—According to the Alzheimer’s Disease International (ADI) international organization about 50 million ...
Neuroprotective Effect of Curcumin on the Rat Model of Parkinson’s Disease Induced by Rotenone via Modulating Tyrosine Hydroxylase and Dopa Decarboxylase Expression Levels
Neuroprotective Effect of Curcumin on the Rat Model of Parkinson’s Disease Induced by Rotenone via Modulating Tyrosine Hydroxylase and Dopa Decarboxylase Expression Levels
Parkinson’s disease is a progressive neurodegenerative disorder distinguished by degeneration of dopaminergic neuron...
Chemotherapy-Induced Peripheral Neuropathy in Children Treated for Acute Lymphoblastic Leukemia: A Role for Oxidative Stress and Brain-Derived Neurotrophic Factor
Chemotherapy-Induced Peripheral Neuropathy in Children Treated for Acute Lymphoblastic Leukemia: A Role for Oxidative Stress and Brain-Derived Neurotrophic Factor
The toxicity of chemotherapy agents to the peripheral nervous system (PNS) often manifests itself as chemotherapy-induced ...
Rapid Alterations of the Expression of Active Caspase-3 and Glucocorticoid Receptors in the Cells of the Striatum during Neuroinflammation
Rapid Alterations of the Expression of Active Caspase-3 and Glucocorticoid Receptors in the Cells of the Striatum during Neuroinflammation
Abstract—Activation of microglia, as resident immune cells of the central nervous system, plays a key role in the pa...
Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy
Microbial Signature Present in Thrombotic Material of Acute Ischemic Stroke Patients Retrieved by Mechanical Thrombectomy
This study is done to examine the microbiota in thrombi retrieved from the middle cerebral artery after mechanical thrombe...
Metabolic Plasticity in Developing and Aging Brain
Metabolic Plasticity in Developing and Aging Brain
Abstract—Brain plasticity is a fundamental phenomenon based on various types of intercellular interactions (synaptic...
Repeated Experience of Aggression Changes in Gene Expression in the Hypothalamus in Male Mice of Two Strains
Repeated Experience of Aggression Changes in Gene Expression in the Hypothalamus in Male Mice of Two Strains
Abstract—Repeated fighting experiences can lead to changes in the neurophysiology and behavior of animals and to the...
Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease
Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurological condition that is accompanied by cognitive decline. The occur...
The Role of TNF-α, TNFRSF1A, and CD40 Gene Polymorphisms in Multiple Sclerosis in the Tomsk Region
The Role of TNF-α, TNFRSF1A, and CD40 Gene Polymorphisms in Multiple Sclerosis in the Tomsk Region
Abstract—We studied the role of the rs1800629 polymorphism of the TNF-α gene; the rs4149584 polymorphism of the...
The Effect of Subchronic Alcoholization on the Behavior and Monoaminergic Systems of the Brains of Mice with a Predisposition to Depression-Like Behavior
The Effect of Subchronic Alcoholization on the Behavior and Monoaminergic Systems of the Brains of Mice with a Predisposition to Depression-Like Behavior
Abstract—Depressive disorders and alcohol dependence are among the most common psychopathologies. It is known that d...
Idelalisib, a Selective Phosphatidylinositol-3-Kinase Inhibitor, Suppresses Pentylenetetrazole-Induced Convulsions in Wistar Rats
Idelalisib, a Selective Phosphatidylinositol-3-Kinase Inhibitor, Suppresses Pentylenetetrazole-Induced Convulsions in Wistar Rats
Epilepsy results from abnormal brain function and is one of the most common neurological diseases in the world. The phosph...
Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine
Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine
Abstract—The mechanisms of the ketamine antidepressant effects observed in humans and laboratory animals are not ful...
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