Anandhan, A., Janakiraman, U., & Manivasagam, T. (2012). Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson’s disease. Neuroscience, 218, 257–267.

Article  CAS  PubMed  Google Scholar 

Antzoulatos, E., Jakowec, M. W., Petzinger, G. M., & Wood, R. I. (2010). Sex differences in motor behavior in the MPTP mouse model of Parkinson’s disease. Pharmacol Biochem Be, 95(4), 466–472.

Article  CAS  Google Scholar 

Arbuthnott, G. W. (2021). An introspective approach: A lifetime of parkinson’s disease research and not much to show for it yet? Cells-Basel, 10(3), 513.

Article  CAS  Google Scholar 

Barrio, J. R., Huang, S. C., Melega, W. P., Yu, D. C., Hoffman, J. M., Schneider, J. S., et al. (1990). 6-[18F]fluoro-L-dopa probes dopamine turnover rates in central dopaminergic structures. Journal of Neuroscience Research, 27(4), 487–493.

Article  CAS  PubMed  Google Scholar 

Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K., & Seitelberger, F. (1973). Brain dopamine and the syndromes of Parkinson and huntington clinical morphological and neurochemical correlations. Journal of the Neurological Science, 20(4), 415–455.

Article  CAS  Google Scholar 

Bezard, E., & Gross, C. E. (1998). Compensatory mechanisms in experimental and human parkinsonism: Towards a dynamic approach. Progress in Neurobiology, 55(2), 93–116.

Article  CAS  PubMed  Google Scholar 

Bezard, E., Jaber, M., Gonon, F., Boireau, A., Bloch, B., & Gross, C. E. (2000). Adaptive changes in the nigrostriatal pathway in response to increased 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration in the mouse. European Journal of Neuroscience, 12(8), 2892–2900.

Article  CAS  PubMed  Google Scholar 

Bezard, E., & Przedborski, S. (2011). A tale on animal models of Parkinson’s disease. Movement Disorders, 26(6), 993–1002.

Article  PubMed  Google Scholar 

Blesa, J., Trigo-Damas, I., Dileone, M., Del, R. N., Hernandez, L. F., & Obeso, J. A. (2017). Compensatory mechanisms in Parkinson’s disease: Circuits adaptations and role in disease modification. Experimental Neurology, 298(Pt B), 148–161.

Article  CAS  PubMed  Google Scholar 

Cai, P., Ye, J., Zhu, J., Liu, D., Chen, D., Wei, X., et al. (2016). Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of bFGF in the 6-OHDA-induced parkinson’s disease model. Aging & Disease, 7(4), 336–449.

Article  Google Scholar 

Cao, L., Li, D., Feng, P., Li, L., Xue, G., Li, G., et al. (2016). A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain. NeuroReport, 27(6), 384–391.

Article  CAS  PubMed  Google Scholar 

Dauer, W., & Przedborski, S. (2003). Parkinson’s disease: Mechanisms and models. Neuron, 39(6), 889–909.

Article  CAS  PubMed  Google Scholar 

Dentresangle, C., Le Cavorsin, M., Savasta, M., & Leviel, V. (2001). Increased extracellular DA and normal evoked DA release in the rat striatum after a partial lesion of the substantia nigra. Brain Research, 893(1–2), 178–185.

Article  CAS  PubMed  Google Scholar 

Dhanushkodi, A., Akano, E. O., Roguski, E. E., Xue, Y., Rao, S. K., Matta, S. G., et al. (2013). A single intramuscular injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced parkinsonism. Genes, Brain and Behavior, 12(2), 224–233.

Article  CAS  PubMed  Google Scholar 

Fearnley, J. M., & Lees, A. J. (1990). Striatonigral degeneration. A clinicopathological study. Brain, 113(Pt 6), 1823–1842.

Article  PubMed  Google Scholar 

Fearnley, J. M., & Lees, A. J. (1991). Ageing and Parkinson’s disease: Substantia nigra regional selectivity. Brain, 114(Pt 5), 2283–2301.

Article  PubMed  Google Scholar 

Fernagut, P. O., Diguet, E., Bioulac, B., & Tison, F. (2004). MPTP potentiates 3-nitropropionic acid-induced striatal damage in mice: Reference to striatonigral degeneration. Experimental Neurology, 185(1), 47–62.

Article  CAS  PubMed  Google Scholar 

Fu, Y., Yuan, Y., Halliday, G., Rusznak, Z., Watson, C., & Paxinos, G. (2012). A cytoarchitectonic and chemoarchitectonic analysis of the dopamine cell groups in the substantia nigra, ventral tegmental area, and retrorubral field in the mouse. Brain Structure & Function, 217(2), 591–612.

Article  Google Scholar 

Fujita, A., Yamaguchi, H., Yamasaki, R., Cui, Y., Matsuoka, Y., Yamada, K., et al. (2018). Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model. J Neuroinflamm. https://doi.org/10.1186/s12974-018-1251-0

Article  Google Scholar 

Gafk, P. (2008). The Mouse Brain in Sereotaxic Coordinates, Compact Third (Vol. 18). Academic Press.

Google Scholar 

Iannielli, A., Bido, S., Folladori, L., Segnali, A., Cancellieri, C., Maresca, A., et al. (2018). Pharmacological inhibition of necroptosis protects from dopaminergic neuronal cell death in Parkinson’s disease models. Cell Reports, 22(8), 2066–2079.

Article  CAS  PubMed  Google Scholar 

Jackson-Lewis, V., & Przedborski, S. (2007). Protocol for the MPTP mouse model of Parkinson’s disease. Nature Protocols, 2(1), 141–151.

Article  CAS  PubMed  Google Scholar 

Kim, S., Kwon, S., Kam, T., Panicker, N., Karuppagounder, S. S., Lee, S., et al. (2019). Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson’s disease. Neuron, 103(4), 627–641.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kin, K., Yasuhara, T., Kameda, M., & Date, I. (2019). Animal models for parkinson’s disease research: Trends in the 2000s. International Journal of Molecular Sciences, 20(21), 5402.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kozina, E. A., Kim, A. R., Kurina, A. Y., & Ugrumov, M. V. (2017). Cooperative synthesis of dopamine by non-dopaminergic neurons as a compensatory mechanism in the striatum of mice with MPTP-induced Parkinsonism. Neurobiology of Diseases, 98, 108–121.

Article  CAS  Google Scholar 

Kraeuter, A., Guest, P. C., & Sarnyai, Z. (2018). The Open Field Test for Measuring Locomotor Activity and Anxiety-Like Behavior (Vol. 1916, pp. 99–103). New York: Springer.

Google Scholar 

Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., et al. (2010). Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature, 466(7306), 622–626.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kwon, S. H., Kim, H. C., Lee, S. Y., & Jang, C. G. (2009). Loganin improves learning and memory impairments induced by scopolamine in mice. European Journal of Pharmacology, 619(1–3), 44–49.

Article  CAS  PubMed  Google Scholar 

Langston, J. W. (2017). The MPTP Story. Journal of Parkinson’s Disease, 7(s1), S11–S19.

Article  PubMed  PubMed Central  Google Scholar 

Lees, A. J., Hardy, J., & Revesz, T. (2009). Parkinson’s disease. Lancet, 373(9680), 2055–2066.

Article  CAS  PubMed  Google Scholar 

Li, R., & Chen, J. (2019). Salidroside protects dopaminergic neurons by enhancing PINK1/parkin-mediated mitophagy. Oxidative Medicine and Cellular Longevity, 2019, 9341018.

Article  PubMed  PubMed Central  Google Scholar 

Liang, Y., Chen, C., Xia, B., Wu, W., Tang, J., Chen, Q., et al. (2019). Neuroprotective effect of echinacoside in subacute mouse model of Parkinson’s disease. BioMed Research International, 2019, 1–8.

Google Scholar 

Liu, Y., Jin, W., Deng, Z., Wang, J., & Zhang, Q. (2020). Preparation and neuroprotective activity of glucuronomannan oligosaccharides in an MPTP-induced Parkinson’s model. Marine Drugs, 18(9), 438.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marchetti, B. (2018). Wnt/β-catenin signaling pathway governs a full program for dopaminergic neuron survival, neurorescue and regeneration in the MPTP mouse model of Parkinson’s disease. International Journal of Molecular Sciences, 19(12), 3743.

Article  PubMed  PubMed Central  Google Scholar 

Marino, B., de Souza, L. R., Sousa, K., Ferreira, J. V., Padilha, E. C., Da, S. C., et al. (2020). Parkinson’s disease: A review from pathophysiology to treatment. Mini Reviews in Medicinal Chemistry, 20(9), 754–767.

Article  CAS  PubMed  Google Scholar 

Mat, T. C., & Mustapha, M. (2020). MPTP-induced mouse model of Parkinson’s disease: A promising direction of therapeutic strategies. Bosnian Journal of Basic Medical Sciences, 21, 422.

Google Scholar 

Meredith, G. E., & Rademacher, D. J. (2011). MPTP mouse models of parkinson’s disease: An update. Journal of Parkinson’s Disease, 1(1), 19–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morales, I., Sanchez, A., Rodriguez-Sabate, C., & Rodriguez, M. (2016). The astrocytic response to the dopaminergic denervation of the striatum. Journal of Neurochemistry, 139(1), 81–95.

Article  CAS  PubMed  Google Scholar 

Nandhagopal, R., Kuramoto, L., Schulzer, M., Mak, E., Cragg, J., Lee, C. S., et al. (2009). Longitudinal progression of sporadic Parkinson’s disease: A multi-tracer positron emission tomography study. Brain, 132(Pt 11), 2970–2979.

Article