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Comprehensive computational analysis of deleterious nsSNPs in PTEN gene for structural and functional insights
Single nucleotide polymorphisms (SNPs) are pivotal in understanding the genetic basis of complex disorders. Among them, no...
Gene co-expression network analysis reveals relationship between leukocyte fraction and genomic instability in dedifferentiated liposarcoma
Dedifferentiated Liposarcoma (DDLPS) is one of the common subtypes of liposarcoma that is considered a highly malignant ca...
Breast cancer susceptibility is associated with Cyclin D1 single nucleotide polymorphisms in Iran: A case-control study
Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the ...
The importance of TP53 status in cancer therapy: The example of chronic lymphocytic leukemia
The TP53 gene encodes the tumor suppressor protein p53, which plays a critical role in genomic stability and cell cycle re...
Comment on: IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study
Dear Editor,I recently read an elegant study by Abdalla1 and Hamdan (2025) published in the Molecular Biology Research Com...
The effect of chemotherapeutic agents on epidermal neural crest stem cells
Human Epidermal Neural Crest Stem Cells (hEPI-NCSCs), as a transient population of multipotent migratory stem cells can di...
Clinical relevance of plasma-derived exosomal long non-coding RNAs (lncRNAs) CCAT1 and XIST in colorectal cancer patients
The expression level of exosomal long non-coding RNAs (lncRNAs) can be relevant for clinical diagnostic approaches. The ob...
Investigation methylation status of tumor suppressor gene NR4A1 and NR4A3 and frequency of rs1569686 polymorphism of DNMT3B gene in patients with acute myeloid leukemia
Acute myeloid leukemia (AML) is the most frequent type of leukemia among adults. Investigating AML heterogeneity based on ...
Pathogenic variants of BUB1 and BUBR1 genes are not prioritized in screening tests of couples with aborted aneuploid fetuses
Chromosome aberrations certainly aneuploidie are the cause of the majority of spontaneous abortions in humans. BUB1 (buddi...
Computational analysis of Ayurvedic herbs to explore their potential role as anti-cervical cancer agents
Cervical cancer is one of the common types of cancer in women. Treatment regimens include use of chemotherapy but it leads...
Effect of 30-day Ramadan fasting on autophagy pathway and metabolic health outcome in healthy individuals
During Ramadan, Muslims fast to spiritually prepare their bodies and spirits. The autophagy pathway restores cellular home...
A review on diabetes and oral cancer: Molecular links and implications
Diabetes mellitus has been linked to an increased risk of oral cancer, with hyperglycemia and chronic inflammation contrib...
k-mer approaches for biodiversity genomics [REVIEW]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Characterization of the role of spatial proximity of DNA double-strand breaks in the formation of CRISPR-Cas9-induced large structural variations [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Ultraviolet damage and repair maps in Drosophila reveal the impact of domain-specific changes in nucleosome repeat length on repair efficiency [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Timescale and genetic linkage explain the variable impact of defense systems on horizontal gene transfer [RESEARCH]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Interactive visualization and interpretation of pangenome graphs by linear reference-based coordinate projection and annotation integration [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Identification of the shortest species-specific oligonucleotide sequences [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Proxy panels enable privacy-aware outsourcing of genotype imputation [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Combining DNA and protein alignments to improve genome annotation with LiftOn [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Kernel-bounded clustering for spatial transcriptomics enables scalable discovery of complex spatial domains [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Diffusion-based generation of gene regulatory networks from scRNA-seq data with DigNet [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Probing the eukaryotic microbes of ruminants with a deep-learning classifier and comprehensive protein databases [METHODS]
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights...
Sedimentation of large, soluble proteins up to 140 kDa for 1H-detected MAS NMR and 13C DNP NMR – practical aspects
Sedimentation of large, soluble proteins up to 140 kDa for 1H-detected MAS NMR and 13C DNP NMR – practical aspects
Solution NMR is typically applied to biological systems with molecular weights < 40 kDa wherea...
Decorating phenylalanine side-chains with triple labeled 13C/19F/2H isotope patterns
Decorating phenylalanine side-chains with triple labeled 13C/19F/2H isotope patterns
We present an economic and straightforward method to introduce 13C-19F spin systems into the deuterated aromatic side chai...
Micromolar fluoride contamination arising from glass NMR tubes and a simple solution for biomolecular applications
Micromolar fluoride contamination arising from glass NMR tubes and a simple solution for biomolecular applications
Fluorine (19F) NMR is emerging as an invaluable analytical technique in chemistry, biochemistry, structural biology, mater...
Deuterium spin relaxation of fractionally deuterated ribonuclease H using paired 475 and 950 MHz NMR spectrometers
Deuterium spin relaxation of fractionally deuterated ribonuclease H using paired 475 and 950 MHz NMR spectrometers
Deuterium (2H) spin relaxation of 13CH2D methyl groups has been widely applied to investigate picosecond-to-nanosecond con...
Quantitative analysis of the slow exchange process by 19F NMR in the presence of scalar and dipolar couplings: applications to the ribose 2′-19F probe in nucleic acids
Quantitative analysis of the slow exchange process by 19F NMR in the presence of scalar and dipolar couplings: applications to the ribose 2′-19F probe in nucleic acids
Solution NMR spectroscopy is a particularly powerful technique for characterizing the functional dynamics of biomolecules,...
Towards cost-effective side-chain isotope labelling of proteins expressed in human cells
Towards cost-effective side-chain isotope labelling of proteins expressed in human cells
Side chain isotope labelling is a powerful tool to study protein structure and interactions by NMR spectroscopy. 1H,13C la...
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