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Cholesterol Metabolism in CNS Diseases: The Potential of SREBP2 and LXR as Therapeutic Targets
Cholesterol Metabolism in CNS Diseases: The Potential of SREBP2 and LXR as Therapeutic Targets
The brain is the organ with the highest cholesterol content in the body. Cholesterol in the brain plays a crucial role in ...
The Roles of DMT1 in Inflammatory and Degenerative Diseases
The Roles of DMT1 in Inflammatory and Degenerative Diseases
Iron homeostasis is critical for multiple physiological and pathological processes. DMT1, a core iron transporter, is expr...
Importance of Gut Microbiota Dysbiosis and Circadian Disruption–Associated Biomarkers in Emergence of Alzheimer’s Disease
Importance of Gut Microbiota Dysbiosis and Circadian Disruption–Associated Biomarkers in Emergence of Alzheimer’s Disease
Alzheimer’s disease (AD) is a major devastating neurodegenerative disorder afflicting majorly the geriatric populati...
Inhibition of Vascular Endothelial Growth Factor Reduces Photoreceptor Death in Retinal Neovascular Disease via Neurotrophic Modulation in Müller Glia
Inhibition of Vascular Endothelial Growth Factor Reduces Photoreceptor Death in Retinal Neovascular Disease via Neurotrophic Modulation in Müller Glia
VEGF is not only the most potent angiogenic factor, but also an important neurotrophic factor. In this study, vitreous exp...
Multilayered Nanocarriers as a New Strategy for Delivering Drugs with Protective and Anti-inflammatory Potential: Studies in Hippocampal Organotypic Cultures Subjected to Experimental Ischemia
Multilayered Nanocarriers as a New Strategy for Delivering Drugs with Protective and Anti-inflammatory Potential: Studies in Hippocampal Organotypic Cultures Subjected to Experimental Ischemia
Oxidative stress and neuroinflammation play a pivotal role in pathomechanisms of brain ischemia. Our research aimed to for...
Amyotrophic Lateral Sclerosis and Parkinson's Disease: Brain Tissue Transcriptome Analysis Reveals Interactions
Amyotrophic Lateral Sclerosis and Parkinson's Disease: Brain Tissue Transcriptome Analysis Reveals Interactions
This study utilises amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) human brain samples from the GEO ...
FGF21 Exhibits Neuroprotective Effects by Promoting 5-HT1AR-FGFR1 Heteroreceptor Complexes and Triggering MEK1/2-ERK1/2 Signaling Pathway
FGF21 Exhibits Neuroprotective Effects by Promoting 5-HT1AR-FGFR1 Heteroreceptor Complexes and Triggering MEK1/2-ERK1/2 Signaling Pathway
Approaches of promoting a neural milieu permissive for plasticity and resilience against neuronal injury are important str...
LncRNA SERPINB9P1 Mitigates Cerebral Injury Induced by Oxygen‒Glucose Deprivation/Reoxygenation by Interacting with HSPA2
LncRNA SERPINB9P1 Mitigates Cerebral Injury Induced by Oxygen‒Glucose Deprivation/Reoxygenation by Interacting with HSPA2
Dysregulation of long non-coding RNAs (lncRNAs) is implicated in the pathophysiology of ischemic stroke (IS). However, the...
Common Variants in PLXNA4 and Correlation to Neuroimaging Phenotypes in Healthy, Mild Cognitive Impairment, and Alzheimer’s Disease Cohorts
Common Variants in PLXNA4 and Correlation to Neuroimaging Phenotypes in Healthy, Mild Cognitive Impairment, and Alzheimer’s Disease Cohorts
A comprehensive genome-wide association study (GWAS) has validated the identification of the Plexin-A 4 (PLXNA4) gene as a...
Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research
Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research
This review explores the current understanding and recent advancements in neuroblastoma, one of the most common extracrani...
A Neuron-Like Cellular Model for Severe Tinnitus Associated with Rare Variations in the ANK2 Gene
A Neuron-Like Cellular Model for Severe Tinnitus Associated with Rare Variations in the ANK2 Gene
Tinnitus is the perception of sound without an external source, often associated with changes in the auditory pathway and ...
Identification, Clinical Values, and Prospective Pathway Signaling of Lipid Metabolism Genes in Epilepsy and AED Treatment
Identification, Clinical Values, and Prospective Pathway Signaling of Lipid Metabolism Genes in Epilepsy and AED Treatment
The dysregulation of lipid metabolism has been associated with the etiology and progression of the neurological pathology....
Extracellular Matrix Alterations Due to Early-Life Adversity: Implications for Auditory Learning in Male Sprague–Dawley Rats
Extracellular Matrix Alterations Due to Early-Life Adversity: Implications for Auditory Learning in Male Sprague–Dawley Rats
This study aimed to investigate the impact of early childhood chronic stress on the development of the brain extracellular...
Correction: Astaxanthin and DHA Supplementation Modulates the Maternal Undernutrition-induced Impairment of Cognitive Behavior and Synaptic Plasticity in Adult Life of Offspring’s -Exploring the Molecular Mechanism
Correction: Astaxanthin and DHA Supplementation Modulates the Maternal Undernutrition-induced Impairment of Cognitive Behavior and Synaptic Plasticity in Adult Life of Offspring’s -Exploring the Molecular Mechanism
Cite this articleAgni, M.B., Hegde, P.S., Rai, P. et al. Correction: Astaxanthin and DHA Supplementation Modulates the Mat...
Insights into the Role of the Glymphatic System in the Pathogenesis of Post-hemorrhagic Hydrocephalus
Insights into the Role of the Glymphatic System in the Pathogenesis of Post-hemorrhagic Hydrocephalus
Recently, it has been well-established that the glymphatic or glial-lymphatic system plays a vital role in the pathophysio...
Neural Stem/Progenitor Cell Therapy in Patients and Animals with Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-analysis
Neural Stem/Progenitor Cell Therapy in Patients and Animals with Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-analysis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative malady that causes progressive degeneration and loss of motor n...
Identification of Potential Intervention Targets Involved in Prior Exercise that Attenuates Peripheral Neuropathic Pain by Integrating Transcriptome and Whole-genome Bisulfite Sequencing Analyses
Identification of Potential Intervention Targets Involved in Prior Exercise that Attenuates Peripheral Neuropathic Pain by Integrating Transcriptome and Whole-genome Bisulfite Sequencing Analyses
Changes in DNA methylation and subsequent alterations in gene expression have opened a new direction in research related t...
Characterizing Genetic-Predisposed Proteins Involving Insomnia by Integrating Genome-Wide Association Study Summary Statistics
Characterizing Genetic-Predisposed Proteins Involving Insomnia by Integrating Genome-Wide Association Study Summary Statistics
Large case–control genome-wide association studies (GWASs) have detected loci associated with insomnia, but how thes...
Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway
Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway
Depression is a common psychological disease with high morbidity and mortality. Recently, the involvement of synaptic plas...
Laminar Distribution of Cannabinoid Receptor 1 in the Prefrontal Cortex of Nonhuman Primates
Laminar Distribution of Cannabinoid Receptor 1 in the Prefrontal Cortex of Nonhuman Primates
Cannabis is an annual herb of the genus Cannabis, with a history of medical use going back thousands of years. However, it...
Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer’s Disease
Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most prevalent form of age-related dementia. Even though a century has passed since ...
Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer’s Disease Patients
Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer’s Disease Patients
The most prevalent form of dementia, Alzheimer’s disease (AD) is a chronic illness that is on the rise among the ger...
Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS) disease characterized by demyelination resultin...
Nano-Mediated Molecular Targeting in Diagnosis and Mitigation of Wilson Disease
Nano-Mediated Molecular Targeting in Diagnosis and Mitigation of Wilson Disease
Wilson disease, a rare genetic disorder resulting from mutations in the ATP7B gene disrupts copper metabolism, leading to ...
Posttreatment with PaPE-1 Protects from Aβ-Induced Neurodegeneration Through Inhibiting the Expression of Alzheimer’s Disease-Related Genes and Apoptosis Process That Involves Enhanced DNA Methylation of Specific Genes
Posttreatment with PaPE-1 Protects from Aβ-Induced Neurodegeneration Through Inhibiting the Expression of Alzheimer’s Disease-Related Genes and Apoptosis Process That Involves Enhanced DNA Methylation of Specific Genes
Targeting the non-nuclear estrogen receptor (ER) signaling has been postulated as novel therapeutic strategy for central n...
Targeted Therapy of Spinal Cord Injury: Inhibition of Apoptosis Is a Promising Therapeutic Strategy
Targeted Therapy of Spinal Cord Injury: Inhibition of Apoptosis Is a Promising Therapeutic Strategy
Spinal cord injury (SCI) is a serious disabling central nervous system injury that can lead to motor, sensory, and autonom...
Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
The aim of this study was to further explore the role of caveolin-1 (Cav-1) related Akt/mTOR signaling pathway in blood br...
Effects of Intestinal M Cells on Intestinal Barrier and Neuropathological Properties in an AD Mouse Model
Effects of Intestinal M Cells on Intestinal Barrier and Neuropathological Properties in an AD Mouse Model
Intestinal microfold cells (M cells) play a critical role in the immune response of the intestinal mucosa by actively taki...
Deferoxamine Ameliorates Cypermethrin-Induced Iron Accumulation and Associated Alterations
Deferoxamine Ameliorates Cypermethrin-Induced Iron Accumulation and Associated Alterations
Iron is widely linked with the onset and development of Parkinson’s disease (PD). Accumulation of iron induces free ...
Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia worldwide...
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