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The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress
Sevoflurane causes neural injury by promoting apoptosis and oxidative stress. Reactive oxygen species modulator 1 (ROMO1) ...
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice
Addressing the intricate challenge of chronic neuropathic pain has significant implications for the physical and psycholog...
A Novel Pathogenic Mutation in WNK1 Gene Causing HSAN Type II in Three Siblings
A Novel Pathogenic Mutation in WNK1 Gene Causing HSAN Type II in Three Siblings
Hereditary sensory and autonomic neuropathy (HSAN) is a rare genetic disorder that primarily affects the peripheral nervou...
Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets
Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets
Mitochondrion is an important organelle present in our cells responsible for meeting energy requirements. All higher organ...
Molecular and Clinical Characterization of a Cohort of Autosomal Recessive Sensorineural Hearing Loss in Egyptian Patients
Molecular and Clinical Characterization of a Cohort of Autosomal Recessive Sensorineural Hearing Loss in Egyptian Patients
Hearing loss (HL) is one of the most common health problems worldwide. Autosomal recessive non-syndromic sensorineural hea...
The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease
The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease
Although brain amyloid-β (Aβ) peptide buildup is the main cause of Alzheimer’s disease (AD), mitochondrial...
The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in Mice
The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in Mice
Chromodomain helicase DNA-binding 8 (CHD8) is a gene that poses a high risk for autism spectrum disorder (ASD) and neurolo...
A Ketogenic Diet Affects Gut Microbiota by Regulating Gut Microbiota and Promoting Hippocampal TRHR Expression to Combat Seizures
A Ketogenic Diet Affects Gut Microbiota by Regulating Gut Microbiota and Promoting Hippocampal TRHR Expression to Combat Seizures
With the persistent challenge that epilepsy presents to therapeutic avenues, the study seeks to decipher the effe...
Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise
Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise
Physical activity has been demonstrated to improve cognitive function, thereby preventing/slowing neurodegenerative diseas...
Antisecretory Factor 16 (AF16): A Promising Avenue for the Treatment of Traumatic Brain Injury—An In Vitro Model Approach
Antisecretory Factor 16 (AF16): A Promising Avenue for the Treatment of Traumatic Brain Injury—An In Vitro Model Approach
Traumatic brain injury (TBI) is caused by an external mechanical force to the head, resulting in abnormal brain functionin...
Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy
Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy
Mitochondria play a pivotal role in cellular metabolism, energy production, and apoptotic signaling, making mitophagy, the...
Role and Interplay of Different Signaling Pathways Involved in Sciatic Nerve Regeneration
Role and Interplay of Different Signaling Pathways Involved in Sciatic Nerve Regeneration
Regeneration of the sciatic nerve is a sophisticated process that involves the interplay of several signaling pathways tha...
Investigation of Association Between Expression of DYX1C1, KIAA0319, and ROBO1 Genes and Specific Learning Disorder in Children and Adolescents
Investigation of Association Between Expression of DYX1C1, KIAA0319, and ROBO1 Genes and Specific Learning Disorder in Children and Adolescents
Specific learning disorder (SLD) is prevalent worldwide and is a complex disorder with variable symptoms and significant d...
Valproate Administration to Adult 5xFAD Mice Upregulates Expression of Neprilysin and Improves Olfaction and Memory
Valproate Administration to Adult 5xFAD Mice Upregulates Expression of Neprilysin and Improves Olfaction and Memory
It is well known that the development of neurodegeneration, and especially Alzheimer’s disease (AD), is often accomp...
Effect of Prednisolone on Clinical and Cytokine mRNA Profiling in Complex Regional Pain Syndrome
Effect of Prednisolone on Clinical and Cytokine mRNA Profiling in Complex Regional Pain Syndrome
The cardinal clinical features of complex regional pain syndrome type I (CRPS-I) are pain, edema, autonomic changes, and l...
Melatonin’s Impact on Cytokine Storm and Modulation of Purinergic Receptors for COVID-19 Prognosis: A Mental Health Perspective
Melatonin’s Impact on Cytokine Storm and Modulation of Purinergic Receptors for COVID-19 Prognosis: A Mental Health Perspective
In 2019, coronavirus disease 2019 (COVID-19) started a global health crisis and was associated with high rates of depressi...
Advanced Glycation End Products in Neurodegenerative Diseases
Advanced Glycation End Products in Neurodegenerative Diseases
Advanced glycation end products (AGEs) have attracted interest as therapeutic targets for neurodegenerative diseases. AGEs...
Exploring the Role of Chemokine-Related Gene Deregulation and Immune Infiltration in Ischemic Stroke: Insights into CXCL16 and SEMA3E as Potential Biomarkers
Exploring the Role of Chemokine-Related Gene Deregulation and Immune Infiltration in Ischemic Stroke: Insights into CXCL16 and SEMA3E as Potential Biomarkers
Ischemic stroke is a leading cause of mortality and disability globally. Understanding the role of chemokine-related diffe...
MicroRNA Expression Profile Is Altered by Short-Term and Chronic Lithium Treatment in a Rat Model of Depression
MicroRNA Expression Profile Is Altered by Short-Term and Chronic Lithium Treatment in a Rat Model of Depression
Depression is a common disease that affects 3.8% of the global population. Despite various antidepressant treatments, one-...
Role of Senataxin in Amyotrophic Lateral Sclerosis
Role of Senataxin in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive, uncurable neurodegenerative disorder characterized by the degradatio...
Correction: Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
Correction: Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
University of Cincinnati Neuroscience Graduate Program, Cincinnati, OH, 45229, USAEmma V. Parkins, Sarah Yaser & Chris...
A Novel Truncating Mutation in PAX1 Gene Causes Otofaciocervical Syndrome Without Immunodeficiency
A Novel Truncating Mutation in PAX1 Gene Causes Otofaciocervical Syndrome Without Immunodeficiency
Otofaciocervical syndrome (OTFCS) is a rare genetic disorder of both autosomal recessive and autosomal dominant patterns o...
A Comprehensive Investigation of Risk Association Between the -786 T > C, + 884 G > A, VNTR, rs743506, rs3918226 of eNOS and Susceptibility of Migraine: A Updated Meta-Analysis Utilizing Trial Sequential Analysis
A Comprehensive Investigation of Risk Association Between the -786 T > C, + 884 G > A, VNTR, rs743506, rs3918226 of eNOS and Susceptibility of Migraine: A Updated Meta-Analysis Utilizing Trial Sequential Analysis
With a feature of complex pathogenic mechanisms, migraine is a well-known common neurovascular disorder. Multiple genes ar...
Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells
Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells
Alzheimer’s disease (AD) is a multifactorial disease affecting aging population worldwide. Neuroinflammation became ...
Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities
Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities
Alzheimer’s disease (AD) is a prevalently neurodegenerative disease characterized by neuronal damage which is associ...
IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM
IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM
Advanced age is an important risk factor for the worse clinical presentation of gliomas, especially glioblastoma (GBM). Th...
The Role of Cystathionine-β-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies
The Role of Cystathionine-β-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies
We aimed to investigate the mechanism underlying the roles of miRNA-377, Cystathionine-β-synthase (CBS), and hydrogen...
A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression
A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression
Many homeostatic genes are thought to play a role in the susceptibility to migraine, making it a highly complex neurovascu...
Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Glioblastoma multiforme (GBM) is a prevalent and aggressive primary brain tumor, presenting substantial treatment challeng...
Assessment of tRNAThr and tRNAGln Variants and Mitochondrial Functionality in Parkinson’s Disease (PD) Patients of Tamil Nadu Population
Assessment of tRNAThr and tRNAGln Variants and Mitochondrial Functionality in Parkinson’s Disease (PD) Patients of Tamil Nadu Population
Parkinson’s disease (PD) is speculated with genetic and environmental factors. At molecular level, the mitochondrial...
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