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Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration
Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration
Neuronal migration and dendritogenesis are dependent on dynamic changes to the microtubule (MT) network. Among various fac...
Optimization of Long-Term Human iPSC-Derived Spinal Motor Neuron Culture Using a Dendritic Polyglycerol Amine-Based Substrate
Optimization of Long-Term Human iPSC-Derived Spinal Motor Neuron Culture Using a Dendritic Polyglycerol Amine-Based Substrate
Human induced pluripotent stem cells (hiPSCs) derived from healthy and diseased individuals can give rise to many cell typ...
Dendritic Polyglycerol Amine: An Enhanced Substrate to Support Long-Term Neural Cell Culture
Dendritic Polyglycerol Amine: An Enhanced Substrate to Support Long-Term Neural Cell Culture
Long-term stable cell culture is a critical tool to better understand cell function. Most adherent cell culture models req...
Effects of Manipulation of Noradrenergic Activities on the Expression of Dopaminergic Phenotypes in Aged Rat Brains
Effects of Manipulation of Noradrenergic Activities on the Expression of Dopaminergic Phenotypes in Aged Rat Brains
This study investigated the effects of the pharmacological manipulation of noradrenergic activities on dopaminergic phenot...
Mechanism of Incisional Pain: Novel Finding on Long Noncoding RNA XIST/miR-340-5p/RAB1A Axis
Mechanism of Incisional Pain: Novel Finding on Long Noncoding RNA XIST/miR-340-5p/RAB1A Axis
The objective of this study is to investigate the effect of long noncoding RNA (lncRNA) XIST on postoperative pain and inf...
Covid-19-Induced Dysautonomia: A Menace of Sympathetic Storm
Covid-19-Induced Dysautonomia: A Menace of Sympathetic Storm
Among the plethora of debilitating neurological disorders of COVID-19 syndrome in survivors, the scope of SARS-CoV-2-induc...
Sevoflurane-Induced miR-211-5p Promotes Neuronal Apoptosis by Inhibiting Efemp2
Sevoflurane-Induced miR-211-5p Promotes Neuronal Apoptosis by Inhibiting Efemp2
Sevoflurane exposure can result in serious neurological side effects including neuronal apoptosis and cognitive impairment...
Dopamine receptor agonist rotigotine-loaded microspheres ameliorates sexual function deteriorated by fluoxetine in depression rats
Dopamine receptor agonist rotigotine-loaded microspheres ameliorates sexual function deteriorated by fluoxetine in depression rats
Low dopamine levels may cause depressive symptoms. Dopamine is also involved in sexual behavior. Rotigotine is a nonergoli...
Innate Immunity and Cell Death in Alzheimer's Disease
Innate Immunity and Cell Death in Alzheimer's Disease
The innate immune system plays key roles in controlling Alzheimer's disease (AD), while secreting cytokines to eliminate p...
The Mesencephalic Periaqueductal Gray, a Further Structure Involved in Breathing Failure Underlying Sudden Infant Death Syndrome
The Mesencephalic Periaqueductal Gray, a Further Structure Involved in Breathing Failure Underlying Sudden Infant Death Syndrome
The aim of this study was to investigate the involvement of the periaqueductal gray (PAG), an area of gray matter surround...
Role of EphrinA3 in HIV-1 Neuropathogenesis
Role of EphrinA3 in HIV-1 Neuropathogenesis
Glial cells perform important supporting functions for neurons through a dynamic crosstalk. Neuron–glia communication is t...
Identification of miRNAs That Mediate Protective Functions of Anti-Cancer Drugs During White Matter Ischemic Injury
Identification of miRNAs That Mediate Protective Functions of Anti-Cancer Drugs During White Matter Ischemic Injury
We have previously shown that two anti-cancer drugs, CX-4945 and MS-275, protect and preserve white matter (WM) architectu...
2021 ASN Virtual Meeting Abstracts
2021 ASN Virtual Meeting Abstracts
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Glycogen Phosphorylase Isoform Regulation of Ventromedial Hypothalamic Nucleus Gluco-Regulatory Neuron 5′-AMP-Activated Protein Kinase and Transmitter Marker Protein Expression
Glycogen Phosphorylase Isoform Regulation of Ventromedial Hypothalamic Nucleus Gluco-Regulatory Neuron 5′-AMP-Activated Protein Kinase and Transmitter Marker Protein Expression
Brain glycogen is remodeled during metabolic homeostasis and provides oxidizable L-lactate equivalents. Brain glycogen pho...
A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury
A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury
Destabilization of blood vessels by the activities of vascular endothelial growth factor (VEGF) and matrix metalloproteina...
Forelimb Motor Skills Deficits Following Thoracic Spinal Cord Injury: Underlying Dopaminergic and Neural Oscillatory Changes in Rat Primary Motor Cortex
Forelimb Motor Skills Deficits Following Thoracic Spinal Cord Injury: Underlying Dopaminergic and Neural Oscillatory Changes in Rat Primary Motor Cortex
The loss of spinal sensorimotor pathways following spinal cord injury (SCI) can induce retrograde neurodegeneration in the...
Astrocytic Hydrogen Sulfide Regulates Supraoptic Cellular Activity in the Adaptive Response of Lactating Rats to Chronic Social Stress
Astrocytic Hydrogen Sulfide Regulates Supraoptic Cellular Activity in the Adaptive Response of Lactating Rats to Chronic Social Stress
Maternal social stress among breastfeeding women can be adapted in chronic process. However, neuroendocrine mechanisms und...
Microglial- and Astrocyte-Specific Expression of Purinergic Signaling Components and Inflammatory Mediators in the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration
Microglial- and Astrocyte-Specific Expression of Purinergic Signaling Components and Inflammatory Mediators in the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration
The present study examined the involvement of purinergic signaling components in the rat model of hippocampal degeneration...
Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes
Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes
Nitric oxide (NO) is a versatile free radical that has been implicated in many biological processes (i.e., vasodilation, n...
17β-Estradiol Attenuates Intracerebral Hemorrhage-Induced Blood–Brain Barrier Injury and Oxidative Stress Through SRC3-Mediated PI3K/Akt Signaling Pathway in a Mouse Model
17β-Estradiol Attenuates Intracerebral Hemorrhage-Induced Blood–Brain Barrier Injury and Oxidative Stress Through SRC3-Mediated PI3K/Akt Signaling Pathway in a Mouse Model
Estrogen is neuroprotective in brain injury models, and steroid receptor cofactor 3 (SRC3) mediates estrogen signaling. We...
Emerging Role of Ferroptosis in the Pathogenesis of Ischemic Stroke: A New Therapeutic Target?
Emerging Role of Ferroptosis in the Pathogenesis of Ischemic Stroke: A New Therapeutic Target?
Ischemic stroke is one of the main causes of high morbidity, mortality, and disability worldwide; however, the treatment m...
Restoration of KCC2 Membrane Localization in Striatal Dopamine D2 Receptor-Expressing Medium Spiny Neurons Rescues Locomotor Deficits in HIV Tat-Transgenic Mice
Restoration of KCC2 Membrane Localization in Striatal Dopamine D2 Receptor-Expressing Medium Spiny Neurons Rescues Locomotor Deficits in HIV Tat-Transgenic Mice
People infected with HIV (PWH) are highly susceptible to striatal and hippocampal damage. Motor and memory impairments are...
Mitochondrial and Organellar Crosstalk in Parkinson’s Disease
Mitochondrial and Organellar Crosstalk in Parkinson’s Disease
Mitochondrial dysfunction is a well-established pathological event in Parkinson’s disease (PD). Proteins misfolding and it...
Oxytocin Modulation of Maternal Behavior and Its Association With Immunological Activity in Rats With Cesarean Delivery
Oxytocin Modulation of Maternal Behavior and Its Association With Immunological Activity in Rats With Cesarean Delivery
Oxytocin (OT), a neuropeptide produced in the supraoptic (SON) and paraventricular (PVN) nuclei, is not only essential for...
Human Umbilical Cord Mesenchymal Stem Cells-Secreted TSG-6 Is Anti-Inflammatory and Promote Tissue Repair After Spinal Cord Injury
Human Umbilical Cord Mesenchymal Stem Cells-Secreted TSG-6 Is Anti-Inflammatory and Promote Tissue Repair After Spinal Cord Injury
Spinal cord injury (SCI) causes patients paralysis and hard to recover. The therapeutic effects of current clinical drugs ...
The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets
The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets
Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischa...
Gut Microbiota and Parkinson’s Disease: Implications for Faecal Microbiota Transplantation Therapy
Gut Microbiota and Parkinson’s Disease: Implications for Faecal Microbiota Transplantation Therapy
Parkinson's disease (PD) ranks the second place among neurodegenerative diseases in terms of its morbidity, which affects ...
B and T Lymphocyte Densities Remain Stable With Age in Human Cortex
B and T Lymphocyte Densities Remain Stable With Age in Human Cortex
One hallmark of human aging is increased brain inflammation represented by glial activation. With age, there is also dimin...
Aspergillus versicolor Inhalation Triggers Neuroimmune, Glial, and Neuropeptide Transcriptional Changes
Aspergillus versicolor Inhalation Triggers Neuroimmune, Glial, and Neuropeptide Transcriptional Changes
Increasing evidence associates indoor fungal exposure with deleterious central nervous system (CNS) health, such as cognit...
Neuronal Pentraxin 1 Promotes Hypoxic-Ischemic Neuronal Injury by Impairing Mitochondrial Biogenesis via Interactions With Active Bax[6A7] and Mitochondrial Hexokinase II
Neuronal Pentraxin 1 Promotes Hypoxic-Ischemic Neuronal Injury by Impairing Mitochondrial Biogenesis via Interactions With Active Bax[6A7] and Mitochondrial Hexokinase II
Mitochondrial dysfunction is a key mechanism of cell death in hypoxic-ischemic brain injury. Neuronal pentraxin 1 (NP1) ha...
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