MicroRNA Expression Profile Is Altered by Short-Term and Chronic Lithium Treatment in a Rat Model of Depression

Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, Rosoklija GB, Stankov A, Arango V, Dwork AJ, Hen R, Mann JJ (2018) Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell 22(4):589-599.e5. https://doi.org/10.1016/J.STEM.2018.03.015

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bromet E, Andrade LH, Hwang I, Sampson NA, Alonso J, de Girolamo G, de Graaf R, Demyttenaere K, Hu C, Iwata N, Karam AN, Kaur J, Kostyuchenko S, Lépine JP, Levinson D, Matschinger H, Mora MEM, Browne MO, Posada-Villa J, … Kessler RC (2011) Cross-national epidemiology of DSM-IV major depressive episode. BMC Medicine, 9. https://doi.org/10.1186/1741-7015-9-90/COMMENTS

Bschor T, Adli M, Baethge C, Eichmann U, Ising M, Uhr M, Modell S, Künzel H, Müller-Oerlinghausen B, Bauer M (2002) Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depression. Neuropsychopharmacol 27(3):470–478. https://doi.org/10.1016/s0893-133x(02)00323-8

Article  CAS  Google Scholar 

Dalla C, Antoniou K, Drossopoulou G, Xagoraris M, Kokras N, Sfikakis A, Papadopoulou-Daifoti Z (2005) Chronic mild stress impact: are females more vulnerable? Neuroscience 135(3):703–714. https://doi.org/10.1016/j.neuroscience.2005.06.068

Article  CAS  PubMed  Google Scholar 

Depressive disorder (depression). (n.d.). Retrieved March 27, 2024, from https://www.who.int/news-room/fact-sheets/detail/depression

Ding R, Su D, Zhao Q, Wang Y, Wang JY, Lv S, Ji X (2023) The role of microRNAs in depression. Front Pharmacol 14:1129186. https://doi.org/10.3389/FPHAR.2023.1129186/BIBTEX

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong S, Xiong W, Yuan J, Li J, Liu J, Xu X (2013) MiRNA-146a regulates the maturation and differentiation of vascular smooth muscle cells by targeting NF-κB expression. Mol Med Rep 8(2):407–412. https://doi.org/10.3892/MMR.2013.1538

Article  PubMed  Google Scholar 

Eletto D, Russo G, Passiatore G, Del Valle L, Giordano A, Khalili K, Gualco E, Peruzzi F (2008) Inhibition of SNAP25 expression by HIV-1 tat involves the activity of mir-128a. J Cell Physiol 216(3):764–770. https://doi.org/10.1002/JCP.21452

Article  CAS  PubMed  PubMed Central  Google Scholar 

Esaki K, Kondo K, Hatano M, Saito T, Kishi T, Umene-Nakano W, Yoshimura R, Nakamura J, Ozaki N, Ikeda M, Iwata N (2013) Further evidence of an association between a genetic variant in BMP7 and treatment response to SSRIs in major depressive disorder. J Hum Genet 58(8):568–569. https://doi.org/10.1038/JHG.2013.52

Article  CAS  PubMed  Google Scholar 

Fan C, Li Y, Lan T, Wang W, Long Y, Yu SY (2022a) Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression. Mol Ther 30(3):1300–1314. https://doi.org/10.1016/J.YMTHE.2021.11.006

Article  CAS  PubMed  Google Scholar 

Fan D, Chen HB, Leng Y, Yang SJ (2022) MiR-24-3p attenuates doxorubicin-induced cardiotoxicity via the Nrf2 pathway in mice. Current medical science. 42(1):48–55. https://doi.org/10.1007/S11596-022-2536-1/METRICS

Article  CAS  PubMed  Google Scholar 

Fan C, Song Q, Wang P, Li Y, Yang M, Yu SY (2018) Neuroprotective effects of ginsenoside-Rg1 against depression-like behaviors via suppressing glial activation, synaptic deficits, and neuronal apoptosis in rats. Frontiers in Immunology, 9. https://doi.org/10.3389/FIMMU.2018.02889/XML/NLM

Farhan M, Wang H, Gaur U, Little PJ, Xu J, Zheng W (2017) FOXO signaling pathways as therapeutic targets in cancer. Int J Biol Sci 13(7):815–827. https://doi.org/10.7150/IJBS.20052

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu Y, Zhang Y, Wang Z, Wang L, Wei X, Zhang B, Wen Z, Fang H, Pang Q, Yi F (2010) Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy. Am J Nephrol 32(6):581–589. https://doi.org/10.1159/000322105

Article  CAS  PubMed  Google Scholar 

Gecys D, Tatarunas V, Veikutiene A, Lesauskaite V (2020) New potential modulators of CYP4F2 enzyme activity in angina pectoris: hsa-miR-24-3p and hsa-miR-34a-5p. Biomarkers 25(1):40–47. https://doi.org/10.1080/1354750X.2019.1690580

Article  CAS  PubMed  Google Scholar 

Gigante AD, Young LT, Yatham LN, Andreazza AC, Nery FG, Grinberg LT, Heinsen H, Lafer B (2011) Morphometric post-mortem studies in bipolar disorder: Possible association with oxidative stress and apoptosis. Int J Neuropsychopharmacol 14(8):1075–1089. https://doi.org/10.1017/S146114571000146X

Article  CAS  PubMed  Google Scholar 

Gunasekaran S, Omkumar RV (2022) miR-146a and miR-200b alter cognition by targeting NMDA receptor subunits. IScience, 25(12). https://doi.org/10.1016/j.isci.2022.105515

He Y, Huang C, Sun X, Long XR, Lv XW, Li J (2012) MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4. Cellular Signalling 24(10):1923–1930. https://doi.org/10.1016/j.cellsig.2012.06.003

Article  CAS  PubMed  Google Scholar 

Iacob E, Light KC, Tadler SC, Weeks HR, White AT, Hughen RW, VanHaitsma TA, Bushnell L, Light AR (2013) Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls. BMC Psychiatry, 13. https://doi.org/10.1186/1471-244X-13-273

Iacona JR, Lutz CS (2019) miR-146a-5p: Expression, regulation, and functions in cancer. Wiley Interdisciplinary Reviews: RNA, 10(4). https://doi.org/10.1002/WRNA.1533

Jeyaseelan K, Lim KY, Armugam A (2008) MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke 39(3):959–966. https://doi.org/10.1161/STROKEAHA.107.500736

Article  CAS  PubMed  Google Scholar 

Jiménez-Sánchez L, Campa L, Auberson YP, Adell A (2014) The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression. Neuropsychopharmacol 39(11):2673–2680. https://doi.org/10.1038/npp.2014.123

Article  CAS  Google Scholar 

Keller MB, Lavori PW, Mueller TI, Endicott J, Coryell W, Hirschfeld RMA, Shea T (1992) Time to recovery, chronicity, and levels of psychopathology in major depression: a 5-year prospective follow-up of 431 subjects. Arch Gen Psychiatry 49(10):809–816. https://doi.org/10.1001/ARCHPSYC.1992.01820100053010

Article  CAS  PubMed  Google Scholar 

Keller J, Gomez R, Williams G, Lembke A, Lazzeroni L, Murphy GM, Schatzberg AF (2017) HPA axis in major depression: Cortisol, clinical symptomatology and genetic variation predict cognition. Mol Psychiatry 22(4):527–536. https://doi.org/10.1038/mp.2016.120

Article  CAS  PubMed  Google Scholar 

Li J, Donath S, Li Y, Qin D, Prabhakar BS, Li P (2010) miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genetics, 6(1). https://doi.org/10.1371/JOURNAL.PGEN.1000795

Liu H, Zhang N, Tian D (2014) MiR-30b is involved in methylglyoxal-induced epithelial-mesenchymal transition of peritoneal mesothelial cells in rats. Cell Mol Biol Lett 19(2):315–329. https://doi.org/10.2478/S11658-014-0199-Z/HTML

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu CP, Zhong M, Sun JX, He J, Gao Y, Qin FX (2021) miR-146a reduces depressive behavior by inhibiting microglial activation. Molecular Medicine Reports, 23(6). https://doi.org/10.3892/MMR.2021.12102

Lopez JP, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C, Han MH, Foster J, Frey BN, Soares CN, Müller DJ, Farzan F, Leri F, Macqueen GM, Feilotter H, … Turecki G (2017) MicroRNAs 146a/b-5 and 425–3p and 24–3p are markers of antidepressant response and regulate MAPK/Wnt-system genes. Nature communications. 8(1):1–12. https://doi.org/10.1038/ncomms15497

Lützner N, Kalbacher H, Krones-Herzig A, Rösl F (2012) FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop. PloS One, 7(7). https://doi.org/10.1371/JOURNAL.PONE.0042166

Mahmood S, Evinová A, Škereňová M, Ondrejka I, Lehotský J (2016) Association of EGF, IGFBP-3 and TP53 gene polymorphisms with major depressive disorder in Slovak population. Central European J Public Health 24(3):223–230. https://doi.org/10.21101/CEJPH.A4301

Article  CAS  Google Scholar 

Malhi GS, Mann JJ (2018) Depression. The Lancet 392(10161):2299–2312. https://doi.org/10.1016/S0140-6736(18)31948-2

Article  Google Scholar 

Malhi GS, Outhred T (2016) Therapeutic mechanisms of lithium in bipolar disorder: recent advances and current understanding. CNS Drugs 30(10):931–949. https://doi.org/10.1007/s40263-016-0380-1

Article  CAS  PubMed  Google Scholar 

Massanett Aparicio J, Xu Y, Li Y, Colantuoni C, Dastgheyb R, Williams DW, Asahchop EL, McMillian JM, Power C, Fujiwara E, Gill MJ, Rubin LH (2021) Plasma microRNAs are associated with domain-specific cognitive function in people with HIV. AIDS 35(11):1795–1804. https://doi.org/10.1097/QAD.0000000000002966

Article  CAS  PubMed  Google Scholar 

Patel PD, Lopez JF, Lyons DM, Burke S, Wallace M, Schatzberg AF (2000) Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain. J Psychiatr Res 34(6):383–392. https://doi.org/10.1016/S0022-3956(00)00035-2

Article  CAS  PubMed  Google Scholar 

Piscopo P, Grasso M, Puopolo M, D’Acunto E, Talarico G, Crestini A, Gasparini M, Campopiano R, Gambardella S, Castellano AE, Bruno G, Denti MA, Confaloni A (2018) Circulating miR-127-3p as a potential biomarker for differential diagnosis in frontotemporal dementia. Journal of Alzheimer’s Disease 65(2):455–464.

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