Neural Stem/Progenitor Cell Therapy in Patients and Animals with Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-analysis

Hulisz D (2018) Amyotrophic lateral sclerosis: disease state overview. Am J Manag Care. 24(15 Suppl):S320–S326

PubMed  Google Scholar 

Brown CA, Lally C, Kupelian V, Flanders WD (2021) Estimated prevalence and incidence of amyotrophic lateral sclerosis and SOD1 and C9orf72 genetic variants. Neuroepidemiology. 55(5):342–353. https://doi.org/10.1159/000516752

Article  PubMed  Google Scholar 

Verma A (2021) Clinical manifestation and management of amyotrophic lateral sclerosis. In: Araki T, editor. Amyotrophic lateral sclerosis [internet]. Brisbane (AU): Exon Publications Chapter 1

Vasta R, Moglia C, Manera U, Canosa A, Grassano M, Palumbo F, Cugnasco P, De Marchi F et al. Piemonte and Valled’Aosta Register for ALS (PARALS) (2022) What is amyotrophic lateral sclerosis prevalence? Amyotroph Lateral Scler Frontotemporal Degener. 23(3-4):203-208.https://doi.org/10.1080/21678421.2021.1936557

Riva N, Agosta F, Lunetta C, Filippi M, Quattrini A (2016) Recent advances in amyotrophic lateral sclerosis. J Neurol. 263(6):1241–54. https://doi.org/10.1007/s00415-016-8091-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morgan S, Orrell RW (2016) Pathogenesis of amyotrophic lateral sclerosis. Br Med Bull. 119(1):87–98. https://doi.org/10.1093/bmb/ldw026

Article  CAS  PubMed  Google Scholar 

Van Damme P, Dewil M, Robberecht W, Van Den Bosch L (2005) Excitotoxicity and amyotrophic lateral sclerosis. Neurodegener Dis. 2(3–4):147–59. https://doi.org/10.1159/000089620

Article  PubMed  Google Scholar 

Bozzo F, Mirra A, Carrì MT (2017) Oxidative stress and mitochondrial damage in the pathogenesis of ALS: new perspectives. Neurosci Lett. 636:3–8. https://doi.org/10.1016/j.neulet.2016.04.065

Article  CAS  PubMed  Google Scholar 

Oakes JA, Davies MC, Collins MO (2017) TBK1: a new player in ALS linking autophagy and neuroinflammation. Mol Brain. 10(1):5. https://doi.org/10.1186/s13041-017-0287-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vandoorne T, De Bock K, Van Den Bosch L (2018) Energy metabolism in ALS: an underappreciated opportunity? Acta Neuropathol. 135(4):489–509. https://doi.org/10.1007/s00401-018-1835-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turner MR, Bowser R, Bruijn L, Dupuis L, Ludolph A, McGrath M, Manfredi G, Maragakis N et al. (2013) Mechanisms, models and biomarkers in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 14 Suppl 1(0 1):19-32. https://doi.org/10.3109/21678421.2013.778554

Je G, Keyhanian K, Ghasemi M (2021) Overview of stem cells therapy in amyotrophic lateral sclerosis. Neurol Res. 43(8):616–632. https://doi.org/10.1080/01616412.2021.1893564

Article  CAS  PubMed  Google Scholar 

Rothstein JD (2017) Edaravone: A new drug approved for ALS. Cell. 171(4):725. https://doi.org/10.1016/j.cell.2017.10.011

Article  CAS  PubMed  Google Scholar 

Bensimon G, Lacomblez L, Meininger V (1994) A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med. 330(9):585–91. https://doi.org/10.1056/NEJM199403033300901

Article  CAS  PubMed  Google Scholar 

Lunn JS, Sakowski SA, Feldman EL (2014) Concise review: stem cell therapies for amyotrophic lateral sclerosis: recent advances and prospects for the future. Stem Cells. 32(5):1099–109. https://doi.org/10.1002/stem.1628

Article  CAS  PubMed  Google Scholar 

Mazzini L, Ferrero I, Luparello V, Rustichelli D, Gunetti M, Mareschi K, Testa L, Stecco A et al (2010) Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: a phase I clinical trial. Exp Neurol. 223(1):229–37. https://doi.org/10.1016/j.expneurol.2009.08.007

Article  CAS  PubMed  Google Scholar 

Mazzini L, Gelati M, Profico DC, Sgaravizzi G, Projetti Pensi M, Muzi G, Ricciolini C, Rota Nodari L et al (2015) Human neural stem cell transplantation in ALS: initial results from a phase I trial. J Transl Med. 13:17. https://doi.org/10.1186/s12967-014-0371-2

Article  PubMed  PubMed Central  Google Scholar 

Ninkina N (2020) Stem cell therapy and FUS[1-359]- transgenic mice: a recent study highlighting a promising ALS model and a promising therapy. CNS Neurosci Ther. 26(5):502–503. https://doi.org/10.1111/cns.13302

Article  PubMed  PubMed Central  Google Scholar 

Gubert F, Bonacossa-Pereira I, Decotelli AB, Furtado M, Vasconcelos-Dos-Santos A, Mendez-Otero R, Santiago MF (2019) Bone-marrow mononuclear cell therapy in a mouse model of amyotrophic lateral sclerosis: functional outcomes from different administration routes. Brain Res. 1712:73–81. https://doi.org/10.1016/j.brainres.2019.02.003

Article  CAS  PubMed  Google Scholar 

Harper JM, Krishnan C, Darman JS, Deshpande DM, Peck S, Shats I et al (2004) Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proc Natl Acad Sci 101:7123–7128. https://doi.org/10.1073/pnas.0401103101

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uccelli A, Milanese M, Principato MC, Morando S, Bonifacino T, Vergani L et al (2012) Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis. Mol Med 18:794–804. https://doi.org/10.2119/molmed.2011.00498

Article  CAS  PubMed  PubMed Central  Google Scholar 

Srivastava AK, Gross SK, Almad AA, Bulte CA, Maragakis NJ, Bulte JWM (2017) Serial in vivo imaging of transplanted allogeneic neural stem cell survival in a mouse model of amyotrophic lateral sclerosis. Exp Neurol 289:96–102. https://doi.org/10.1016/j.expneurol.2016.12.011

Article  PubMed  Google Scholar 

Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S et al (2014) Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Stem Cell Rep 3:242–249. https://doi.org/10.1016/j.stemcr.2014.05.017

Article  CAS  Google Scholar 

Lin TJ, Cheng GC, Wu LY, Lai WY, Ling TY, Kuo YC, Huang YH (2022) Potential of cellular therapy for ALS: current strategies and future prospects. Front Cell Dev Biol. 10:851613. https://doi.org/10.3389/fcell.2022.851613

Article  PubMed  PubMed Central  Google Scholar 

Liu D, Pavathuparambil Abdul Manaph N, Al-Hawwas M, Bobrovskaya L, Xiong LL, Zhou XF (2020) Coating materials for neural stem/progenitor cell culture and differentiation. Stem Cells Dev 29(8):463-474. 10.1089/ scd.2019.0288

Clarke DL, Johansson CB, Wilbertz J, Veress B, Nilsson E, Karlstrom H et al (2000) Generalized potential of adult neural stem cells. Science. 288(5471):1660–1663

Article  CAS  PubMed  Google Scholar 

Xu L, Yan J, Chen D, Welsh AM, Hazel T, Johe K et al (2006) Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats. Transplantation 82:865–875

Article  PubMed  Google Scholar 

Feldman EL, Boulis NM, Hur J, Johe K, Rutkove SB, Federici T, Polak M, Bordeau J et al (2014) Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes. Ann Neurol. 75(3):363–73. https://doi.org/10.1002/ana.24113

Article  PubMed  PubMed Central  Google Scholar 

Glass JD, Boulis NM, Johe K, Rutkove SB, Federici T, Polak M, Kelly C, Feldman EL (2012) Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients. Stem Cells. 30(6):1144–51. https://doi.org/10.1002/stem.1079

Article  CAS  PubMed  Google Scholar 

Mazzini L, Gelati M, Profico DC, Sorarù G, Ferrari D, Copetti M, Muzi G, Ricciolini C et al (2019) ALS-NSCs Trial Study Group. Results from phase i clinical trial with intraspinal injection of neural stem cells in amyotrophic lateral sclerosis: a long-term outcome. Stem Cells Transl Med. 8(9):887–897. https://doi.org/10.1002/sctm.18-0154

Article  PubMed  PubMed Central  Google Scholar 

Glass JD, Hertzberg VS, Boulis NM, Riley J, Federici T, Polak M, Bordeau J, Fournier C (2016) Transplantation of spinal cord-derived neural stem cells for ALS: analysis of phase 1 and 2 trials. Neurology. 87(4):392–400. https://doi.org/10.1212/WNL.0000000000002889

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif