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COVID-19: from emerging variants to vaccination
COVID-19: from emerging variants to vaccination
The vigorous spread of SARS-CoV-2 resulted in the rapid infection of millions of people worldwide and devastation of not o...
Harnessing the Potential of CD40 Agonism in Cancer Therapy
Harnessing the Potential of CD40 Agonism in Cancer Therapy
Dr. Chi Yan is an Assistant Professor in the Department of Pharmacology at Vanderbilt University School of Medicine, Nashv...
Radiation-targeted immunotherapy: a new perspective in cancer radiotherapy
Radiation-targeted immunotherapy: a new perspective in cancer radiotherapy
Radiation therapy is widely used in cancer treatment[1], [2]. Its mechanism is to destroy the DNA of cancer cells through ...
The impact of COVID-19 on cancer patients
The impact of COVID-19 on cancer patients
In December 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus causing Coronavirus di...
An emerging paradigm of CXCL12 involvement in the metastatic cascade
An emerging paradigm of CXCL12 involvement in the metastatic cascade
George S. Karagiannis, D.V.M, Ph.D. is an assistant professor in the Department of Microbiology and Immunology at the Albe...
Progranulinopathy: A Diverse Realm of Disorders Linked to Progranulin Imbalances
Progranulinopathy: A Diverse Realm of Disorders Linked to Progranulin Imbalances
Progranulin (PGRN), also known as granulin–epithelin precursor (GEP), proepithelin, acrogranin, and GP88/PC-cell derived g...
Immunosuppressive Tumor Microenvironment and Uterine Fibroids:Role in Collagen Synthesis
Immunosuppressive Tumor Microenvironment and Uterine Fibroids:Role in Collagen Synthesis
Uterine fibroids (UF), also known as leiomyoma, is a benign uterine tumor with an unclear etiology that predominately affe...
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: biological and clinical aspects
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: biological and clinical aspects
Andrea Pretta is a MD specialized in Medical Oncology and a Researcher He works in the Medical Oncology Department at the ...
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors
Dr. Bin Di, Ph.D. is a professor of pharmaceutical analysis and vice-dean of School of Pharmacy in the China Pharmaceutica...
The Odyssey of cGAS: from Cytosol to Nucleus
The Odyssey of cGAS: from Cytosol to Nucleus
Dr. Li is an Associate Professor at Tulane University, New Orleans, LA, USA. He received a Ph.D. from Wuhan University in ...
Extracellular Vesicles in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Therapy
Extracellular Vesicles in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Therapy
Extracellular vesicles (EVs) are heterogeneous cell-derived lipid-bilayer membranous nanoparticles serving as intercellula...
Bioengineering strategies to enhance the interleukin-18 bioactivity in the modern toolbox of cancer immunotherapy
Bioengineering strategies to enhance the interleukin-18 bioactivity in the modern toolbox of cancer immunotherapy
The collaboration of immunology and oncology for cancer treatment has experienced revolutionary development during the rec...
Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway
Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway
The human innate immune system plays a crucial role as the first line of defense against the invasion of harmful substance...
Unravelling the Immunobiology of Innate Lymphoid Cells (ILCs): Implications in Health and Disease
Unravelling the Immunobiology of Innate Lymphoid Cells (ILCs): Implications in Health and Disease
Innate lymphoid cells (ILCs) are a newly identified class of innate immune cells that are derived from multipotent hematop...
Extracellular Vesicles in cancer: Shaping the intricate network of metabolic reprogramming and immune interactions in the tumor microenvironment
Extracellular Vesicles in cancer: Shaping the intricate network of metabolic reprogramming and immune interactions in the tumor microenvironment
Federica Anastasi, Asia Botto, Benoit Immordino, Elisa Giovannetti, Liam A. McDonnell. Proteomics analysis of...Jordan Fyf...
Exosome-mediated metabolic reprogramming: implications in esophageal carcinoma progression and tumor microenvironment remodeling
Exosome-mediated metabolic reprogramming: implications in esophageal carcinoma progression and tumor microenvironment remodeling
Xing Niu graduated from China Medical University. Now, his research mainly focuses on the study of artificial intelligence...
Multifaceted Role of CD14 in Innate Immunity and Tissue Homeostasis
Multifaceted Role of CD14 in Innate Immunity and Tissue Homeostasis
Byung-Chul Oh obtained his Ph.D. from Seoul National University in 2001 and further improved his expertise as a postdoctor...
Role of Lipid Signalling in Extracellular Vesicles-mediated Cell-to-cell Communication
Role of Lipid Signalling in Extracellular Vesicles-mediated Cell-to-cell Communication
Prof Marco Falasca is a full-time researcher with over 30 year-experience and a track record in signal transduction in can...
The Critical Role of Osteopontin (OPN) in Fibrotic Diseases
The Critical Role of Osteopontin (OPN) in Fibrotic Diseases
Human fibrotic diseases constitute a significant human health problem, reflecting a global unmet medical need for therapeu...
The cytokine trio - visfatin, placental growth factor and fractalkine – and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA)
The cytokine trio - visfatin, placental growth factor and fractalkine – and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA)
ACSacute coronary syndromeAMIacute myocardial infarctionANPatrial natriuretic peptideBNPbrain natriuretic peptideCADcorona...
Extracellular vesicles as a novel mediator of interkingdom communication
Extracellular vesicles as a novel mediator of interkingdom communication
Extracellular vesicles (EVs) are nanosized lipid bilayer-delimited particles secreted from almost all types of cells inclu...
Proteomics analysis of circulating small extracellular vesicles: focus on the contribution of EVs to tumor metabolism.
Proteomics analysis of circulating small extracellular vesicles: focus on the contribution of EVs to tumor metabolism.
The extracellular space of any multicellular organism contains many different components, such as ions, proteins, oligosac...
Ferroptosis in Cancer Immunity and Immunotherapy: Multifaceted Interplay and Clinical Implications
Ferroptosis in Cancer Immunity and Immunotherapy: Multifaceted Interplay and Clinical Implications
Recently, the study of the types of non-apoptotic cell death, such as necroptosis, pyroptosis, and ferroptosis, has drawn ...
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells
The tumor microenvironment (TME) is a multifaceted and dynamic system that plays a crucial role in tumor initiation, progr...
Extracellular Vesicles: Emerging Mediators of Cell Communication in Gastrointestinal Cancers Exhibiting Metabolic Abnormalities
Prof. Godefridus J Peters from VUmc Cancer Center Amsterdam, Netherlands is an internationally reputed scientist in the fi...
Exosomes as a modulator of immune resistance in human cancers
The tumor microenvironment (TME) is a community consisting of tumor cells, various types of non-cancerous cells (e.g., imm...
Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer
Dr. Guichen Li, professor and chief physician of Pancreaticobiliary Surgery department, the First Affiliated Hospital of C...
The role of microglial activation on ischemic stroke: modulation by fibroblast growth factors
Ischemic stroke is one of the leading causes of death and disability globally, which accounts for approximately 87% of all...
Role of Exosomes in Transferring Chemoresistance Through Modulation of Cancer Glycolytic Cell Metabolism
Elisa Giovannetti, MD, PhD. received her M.D. and Ph.D. with full marks and from the University of Pisa, Italy, in 2000 an...
Brain-Derived Neurotrophic Factor: Its Role in Energy Balance and Cancer Cachexia
Brain-derived neurotrophic factor (BDNF) is one of the most studied members of the neurotrophin family. It is ubiquitously...
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