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Chi hotspot Control of RecBCD Helicase-nuclease: Enzymatic Tests Support the Intramolecular Signal-transduction Model
Chi hotspot Control of RecBCD Helicase-nuclease: Enzymatic Tests Support the Intramolecular Signal-transduction Model
When their DNA is broken, cells must repair it or they die. Faithful repair occurs by the reactions that can promote homol...
Assembly of Protein Complexes in and on the Membrane with Predicted Spatial Arrangement Constraints
Assembly of Protein Complexes in and on the Membrane with Predicted Spatial Arrangement Constraints
Protein-protein interactions are fundamental to many biological processes in living cells. Membrane proteins play an essen...
Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter
Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter
G-quadruplexes (or “G4s”) are non-canonical nucleic acid structures formed by guanine-rich DNA or RNA sequences. They are ...
Aberrant Topologies of Bacterial Membrane Proteins Revealed by High Sensitivity Fluorescence Labelling
Aberrant Topologies of Bacterial Membrane Proteins Revealed by High Sensitivity Fluorescence Labelling
Keywordsmembrane protein topologyperiplasmfluorescenceTat protein transportEscherichia coliData availabilityCustom written...
Tetrameric UvrD Helicase Is Located at the E. Coli Replisome due to Frequent Replication Blocks
Tetrameric UvrD Helicase Is Located at the E. Coli Replisome due to Frequent Replication Blocks
Journal of Molecular BiologyVolume 436, Issue 2, 15 January 2024, 168369Author links open overlay panel, , , , , , , , , H...
Mycobacterium tuberculosis Ku Stimulates Multi-round DNA Unwinding by UvrD1 Monomers
Mycobacterium tuberculosis Ku Stimulates Multi-round DNA Unwinding by UvrD1 Monomers
About one-third of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb), the causative a...
Near-Infrared Optogenetic Module for Conditional Protein Splicing
Near-Infrared Optogenetic Module for Conditional Protein Splicing
Inteins are a unique class of proteins that are capable of self-excision from larger polypeptides by ligation of flanking ...
Different Low-complexity Regions of SFPQ Play Distinct Roles in the Formation of Biomolecular Condensates
Different Low-complexity Regions of SFPQ Play Distinct Roles in the Formation of Biomolecular Condensates
Keywordsphase separationprion-likeDrosophila-behaviour human splicing proteinsDNA repairparaspeckleAbbreviationsCsatsatura...
Mechanism of δ Mediated Transcription Activation in Bacillus subtilis: Interaction with α CTD of RNA Polymerase Stabilizes δ and Successively Facilitates the Open Complex Formation
Mechanism of δ Mediated Transcription Activation in Bacillus subtilis: Interaction with α CTD of RNA Polymerase Stabilizes δ and Successively Facilitates the Open Complex Formation
Transcription is the first step in gene regulation and is performed by RNA polymerase (RNAP). RNAP core enzyme that cataly...
Molecular Architecture of Salmonella Typhimurium Virus P22 Genome Ejection Machinery
Molecular Architecture of Salmonella Typhimurium Virus P22 Genome Ejection Machinery
Salmonella enterica Serovar typhimurium infects 100,000 people annually and causes Salmonellosis, which can be potentially...
Characterizing Different Modes of Interplay Between Rap1 and H3 Using Inducible H3-depletion Yeast
Characterizing Different Modes of Interplay Between Rap1 and H3 Using Inducible H3-depletion Yeast
Keywordstranscription factorhistonechromatin immunoprecipitationRNA sequencingepigeneticsData availabilityRNA-seq and ChIP...
Emerging Trends in Cryo-EM-based Structural Studies of Neuropathological Amyloids
Emerging Trends in Cryo-EM-based Structural Studies of Neuropathological Amyloids
Amyloid fibrils are filamentous aggregates of misfolded proteins that, despite their diversity in sequence, embrace a char...
Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein
Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein
Actin assembly and disassembly are important for directing the shape and movement of cells and tissues during normal devel...
A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases
A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases
The Y-family DNA polymerases – Pol ι, Pol η, Pol κ and Rev1 – are most well-known for their roles in the DNA damage tolera...
Antibody and B-cell Immune Responses Against Bordetella Pertussis Following Infection and Immunization
Antibody and B-cell Immune Responses Against Bordetella Pertussis Following Infection and Immunization
In humans, pertussis (or “whooping cough”) disease is caused by Bordetella pertussis, a Gram-negative, aerobic coccobacill...
Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain
Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain
Keywordsneurodevelopmental disordersautism spectrum disordercancerallosteric mutationstumor suppressorAbbreviationsPTENpho...
Identification of RBM46 as A Novel APOBEC1 Cofactor for C-to-U RNA-Editing Activity
Identification of RBM46 as A Novel APOBEC1 Cofactor for C-to-U RNA-Editing Activity
The APOBEC deaminase family plays a crucial role in a diverse array of biological functions by catalyzing the conversion o...
What Strengthens Protein-Protein Interactions: Analysis and Applications of Residue Correlation Networks
What Strengthens Protein-Protein Interactions: Analysis and Applications of Residue Correlation Networks
Understanding what drives protein–protein binding and selecting appropriate protein residues for modification to strengthe...
Determinants of Developability and Evolvability of Synthetic Miniproteins as Ligand Scaffolds
Determinants of Developability and Evolvability of Synthetic Miniproteins as Ligand Scaffolds
Engineered proteins empower biotechnologies in industrial, medical, and agricultural settings. Specifically, molecular rec...
Coordination of Primer Initiation Within the Catalytic Domain of Human PrimPol
Coordination of Primer Initiation Within the Catalytic Domain of Human PrimPol
Journal of Molecular BiologyVolume 435, Issue 24, 15 December 2023, 168338Author links open overlay panel, , Highlights•To...
Solution Structure of Poly(UG) RNA
Solution Structure of Poly(UG) RNA
Approximately 3% of the human genome is composed of simple sequence repeats, or microsatellites, thought to arise from sli...
Multiple roles of a conserved glutamate residue for unique biophysical properties in a new group of microbial rhodopsins homologous to TAT rhodopsin
Multiple roles of a conserved glutamate residue for unique biophysical properties in a new group of microbial rhodopsins homologous to TAT rhodopsin
Microbial rhodopsins are photoreceptive membrane proteins of microorganisms with diverse functions, light-driven ion pumps...
MAPPING MOLECULAR INTERACTION INTERFACE BETWEEN DIAPHANOUS FORMIN-2 AND NEURON-SPECIFIC DREBRIN A
MAPPING MOLECULAR INTERACTION INTERFACE BETWEEN DIAPHANOUS FORMIN-2 AND NEURON-SPECIFIC DREBRIN A
Keywordsactindrebrinforminmass spectrometrymolecular interaction interfacemappingAbbreviationsDrbA-FLfull length recombina...
Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase
Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase
In eukaryotes, DNA polymerase α-primase (pol-prim) initiates DNA synthesis during replication, generating the first ∼30 nu...
Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation
Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation
Author links open overlay panel, , , , , , , , , , , , , , , , , AbstractLight chain amyloidosis (AL) is a systemic diseas...
Benefits of combining Molecular Biology and Controlled Human Infection Model methodologies in advancing Vaccine Development
Benefits of combining Molecular Biology and Controlled Human Infection Model methodologies in advancing Vaccine Development
Vaccines have been instrumental in reducing morbidity and mortality from infectious diseases and improving quality of life...
The role of ribosomal proteins eL15 and eL36 in the early steps of yeast 60S ribosomal subunit assembly
The role of ribosomal proteins eL15 and eL36 in the early steps of yeast 60S ribosomal subunit assembly
Ribosomes are sophisticated cellular organelles that catalyze translation of the mRNAs into proteins 1, 2. In all organism...
Molecular property, manipulation, and potential use of Opn5 and its homologs
Molecular property, manipulation, and potential use of Opn5 and its homologs
Author links open overlay panel, AbstractAnimal opsin is a G-protein coupled receptor (GPCR) and binds retinal as a chromo...
Structure of the Borrelia bacteriophage φBB1 procapsid
Structure of the Borrelia bacteriophage φBB1 procapsid
Author links open overlay panel, , Highlights•Cryo-EM structure of the prolate procapsids of Borrelia prophage φBB1.•Parti...
Activation Loop Plasticity and Active Site Coupling in the MAP Kinase, ERK2
Activation Loop Plasticity and Active Site Coupling in the MAP Kinase, ERK2
The MAP kinases, ERK1 and ERK2, are key effectors in the MAP kinase cascade, a signaling pathway downstream of RAS that is...
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