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An accessible workflow for high-sensitivity proteomics using parallel accumulation–serial fragmentation (PASEF)
An accessible workflow for high-sensitivity proteomics using parallel accumulation–serial fragmentation (PASEF)
Deep and accurate proteome analysis is crucial for understanding cellular processes and disease mechanisms; however, it is...
Generating allogeneic CAR-NKT cells for off-the-shelf cancer immunotherapy with genetically engineered HSP cells and feeder-free differentiation culture
Generating allogeneic CAR-NKT cells for off-the-shelf cancer immunotherapy with genetically engineered HSP cells and feeder-free differentiation culture
The clinical potential of current chimeric antigen receptor-engineered T (CAR-T) cell therapy is hampered by its autologou...
Photothermal nanofiber-mediated photoporation for gentle and efficient intracellular delivery of macromolecules
Photothermal nanofiber-mediated photoporation for gentle and efficient intracellular delivery of macromolecules
Photoporation with free photothermal nanoparticles (NPs) is a promising technology for gentle delivery of functional bioma...
A multifunctional sensor for cell traction force, matrix remodeling and biomechanical assays in self-assembled 3D tissues in vitro
A multifunctional sensor for cell traction force, matrix remodeling and biomechanical assays in self-assembled 3D tissues in vitro
Cell–matrix interactions, mediated by cellular force and matrix remodeling, result in dynamic reciprocity that drive...
fMRI data acquisition and analysis for task-free, anesthetized rats
fMRI data acquisition and analysis for task-free, anesthetized rats
Templates for the acquisition of large datasets such as the Human Connectome Project guide the neuroimaging community to r...
A multimodal imaging pipeline to decipher cell-specific metabolic functions and tissue microenvironment dynamics
A multimodal imaging pipeline to decipher cell-specific metabolic functions and tissue microenvironment dynamics
Tissue microenvironments are extremely complex and heterogeneous. It is challenging to study metabolic interaction between...
Biomarker analysis from complex biofluids by an on-chip chemically modified light-controlled vertical nanopillar array device
Biomarker analysis from complex biofluids by an on-chip chemically modified light-controlled vertical nanopillar array device
Nanostructured devices have proven useful in a broad range of applications, from diagnosing diseases to discovering and sc...
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice
Establishing reliable intravenous catheterization in mice with optical implants allows the combination of neural manipulat...
In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation
In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation
The central nervous system (CNS) comprises diverse and morphologically complex cells. To understand the molecular basis of...
Synthesis and functionalization of scalable and versatile 2D protein films via amyloid-like aggregation
Synthesis and functionalization of scalable and versatile 2D protein films via amyloid-like aggregation
Two-dimensional (2D) protein films can be used to modify the properties of surfaces, and find applications predominantly i...
Small RNA structural biochemistry in a post-sequencing era
Small RNA structural biochemistry in a post-sequencing era
High-throughput sequencing has had an enormous impact on small RNA research during the past decade. However, sequencing on...
Spatiotemporal control of RNA metabolism and CRISPR–Cas functions using engineered photoswitchable RNA-binding proteins
Spatiotemporal control of RNA metabolism and CRISPR–Cas functions using engineered photoswitchable RNA-binding proteins
RNA molecules perform various crucial roles in diverse cellular processes, from translating genetic information to decodin...
Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst
Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst
The tail-to-head terpene (THT) cyclization is a biochemical process that gives rise to many terpene natural product skelet...
A platform for whole-genome speed introgression from Aegilops tauschii to wheat for breeding future crops
A platform for whole-genome speed introgression from Aegilops tauschii to wheat for breeding future crops
Breeding new and sustainable crop cultivars of high yields and desirable traits has been a major challenge for ensuring fo...
CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction
CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction
Intratumor heterogeneity provides the fuel for the evolution and selection of subclonal tumor cell populations. However, a...
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input
These authors contributed equally: Tetsuya Handa, Akihito Harada, Kazumitsu Maehara.Cell Biology Center, Institute of Inno...
Reproducible strategy for excisional skin-wound-healing studies in mice
Reproducible strategy for excisional skin-wound-healing studies in mice
Wound healing is a complex physiological process involving various cell types and signaling pathways. The capability to ob...
Robust scoring of selective drug responses for patient-tailored therapy selection
Robust scoring of selective drug responses for patient-tailored therapy selection
Most patients with advanced malignancies are treated with severely toxic, first-line chemotherapies. Personalized treatmen...
Analyzing somatic mutations by single-cell whole-genome sequencing
Analyzing somatic mutations by single-cell whole-genome sequencing
Somatic mutations are the cause of cancer and have been implicated in other, noncancerous diseases and aging. While clonal...
Ultra-fast supercritically solvothermal polymerization for large single-crystalline covalent organic frameworks
Ultra-fast supercritically solvothermal polymerization for large single-crystalline covalent organic frameworks
Crystalline polymer materials, e.g., hyper-crosslinked polystyrene, conjugate microporous polymers and covalent organic fr...
High-throughput identification and quantification of bacterial cells in the microbiota based on 16S rRNA sequencing with single-base accuracy using BarBIQ
High-throughput identification and quantification of bacterial cells in the microbiota based on 16S rRNA sequencing with single-base accuracy using BarBIQ
Bacteria often function as a community, called the microbiota, consisting of many different bacterial species. The accurat...
Fabrication of angstrom-scale two-dimensional channels for mass transport
Fabrication of angstrom-scale two-dimensional channels for mass transport
Fluidic channels at atomic scales regulate cellular trafficking and molecular filtration across membranes, and thus play c...
Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS
Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS
Non-negative matrix factorization (NMF) is an unsupervised learning method well suited to high-throughput biology. However...
Co-fractionation–mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain
Co-fractionation–mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain
Human mitochondrial (mt) protein assemblies are vital for neuronal and brain function, and their alteration contributes to...
A nanobody-based strategy for rapid and scalable purification of human protein complexes
A nanobody-based strategy for rapid and scalable purification of human protein complexes
The isolation of proteins in high yield and purity is a major bottleneck for the analysis of their three-dimensional struc...
Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo
Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo
Light is used extensively in biological and medical research for optogenetic neuromodulation, fluorescence imaging, photoa...
Construction and use of an adaptive optics two-photon microscope with direct wavefront sensing
Construction and use of an adaptive optics two-photon microscope with direct wavefront sensing
Two-photon microscopy, combined with the appropriate optical labelling, enables the measurement and tracking of submicrome...
EpiTyping: analysis of epigenetic aberrations in parental imprinting and X-chromosome inactivation using RNA-seq
EpiTyping: analysis of epigenetic aberrations in parental imprinting and X-chromosome inactivation using RNA-seq
Human pluripotent stem cells (hPSCs) hold a central role in studying human development, in disease modeling and in regener...
Scalable single-cell profiling of chromatin modifications with sciCUT&Tag
Scalable single-cell profiling of chromatin modifications with sciCUT&Tag
Cleavage under targets and tagmentation (CUT&Tag) is an antibody-directed in situ chromatin profiling strategy tha...
Experimental modulation of physiological force application on leg joint neurons in intact Drosophila melanogaster
Experimental modulation of physiological force application on leg joint neurons in intact Drosophila melanogaster
The study of how mechanical forces affect biological events in living tissue is important for the understanding of a multi...
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