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Crystal structure of cytochrome P450 NysL and the structural basis for stereo- and regio-selective oxidation of antifungal macrolides
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Auranofin induces disulfide bond–mimicking S-Au adducts in protein thiol pairs
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Recombinant antibodies inhibit enzymatic activity of the E3 ubiquitin ligase CHIP via multiple mechanisms
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Light-chain split luciferase assay implicates pathological NOTCH3 thiol reactivity in inherited cerebral small vessel disease
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Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery
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Extremophilic hemoglobins: The structure of Shewanella benthica truncated hemoglobin N
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Modulating the complement system through epitope-specific inhibition by complement C3 inhibitors
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Dentin sialoprotein acts as an angiogenic factor through association with the membrane receptor endoglin
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Aggregated proinsulin in pancreatic β-cells is degraded by the autophagy pathway
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TET1 participates in oxaliplatin-induced neuropathic pain by regulating microRNA-30b/Nav1.6
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Exogenous L-fucose attenuates depression induced by chronic unpredictable stress: Implicating core fucosylation has an antidepressant potential
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p53-mediated regulation of LINE1 retrotransposon-derived R-loops
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The levels of the long noncoding RNA MALAT1 affect cell viability and modulate TDP-43 binding to mRNA in the nucleus
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Drosophila Modulo is essential for transposon silencing and developmental robustness
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Mechanisms of dual modulatory effects of spermine on the mitochondrial calcium uniporter complex
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Phosphorylation of distal C-terminal residues promotes TRPV4 channel activation in response to arachidonic acid
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Correction: Three prime repair exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural, and conformational properties
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Correction: KLF6 activates Sp1-mediated prolidase transcription during TGF-β1 signaling
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Correction: A putative cAMP-binding protein in Trypanosoma brucei cooperates with FLAM3 to promote flagellar connection and cell morphogenesis
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Withdrawal: RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells
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Reprogramming and multi-lineage transdifferentiation attenuate the tumorigenicity of colorectal cancer cells
Reprogramming and multi-lineage transdifferentiation attenuate the tumorigenicity of colorectal cancer cells
Author links open overlay panel, , , , , , , , , , , AbstractSignificant advances have been made in reprogramming various ...
Functionally redundant formate dehydrogenases enable formate-dependent growth in Methanococcus maripaludis
Functionally redundant formate dehydrogenases enable formate-dependent growth in Methanococcus maripaludis
Author links open overlay panel, , , AbstractMethanogens are essential for the complete remineralization of organic matter...
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex
Author links open overlay panel, , , , , Abstract:The γ-secretase complexes are intramembrane cleaving proteases involved ...
Structure of Mycobacterial ergothioneine-biosynthesis C-S lyase EgtE
Structure of Mycobacterial ergothioneine-biosynthesis C-S lyase EgtE
Key wordsMycobacteriumprotein structureredox homeostasis ErgothioneineErgothioneine-Biosynthesis C-S lyaseMsEgtENcEgt2The ...
Matrixed CDR-grafting: a neoclassical framework for antibody humanization and developability
Matrixed CDR-grafting: a neoclassical framework for antibody humanization and developability
Author links open overlay panel, , , , , , , , ABSTRACT:Discovery and optimization of a biotherapeutic monoclonal antibody...
Structure, dynamics and stability of the smallest and most complex 71 protein knot
Structure, dynamics and stability of the smallest and most complex 71 protein knot
Proteins can spontaneously tie a variety of intricate topological knots through twisting and threading of the polypeptide ...
Uropathogenic Escherichia coli wield enterobactin-derived catabolites as siderophores
Uropathogenic Escherichia coli wield enterobactin-derived catabolites as siderophores
Author links open overlay panel, , , ABSTRACTUropathogenic E. coli (UPEC) secrete multiple siderophore types to scavenge e...
Transcriptional Regulation of FACT Involves Coordination of Chromatin Accessibility and CTCF Binding
Transcriptional Regulation of FACT Involves Coordination of Chromatin Accessibility and CTCF Binding
Author links open overlay panel, , , , , , , , , , AbstractHistone chaperone FACT is well known to promote chromatin recov...
Structural characterization and functional insights into the Type II Secretion System of the poly-extremophile Deinococcus radiodurans
Structural characterization and functional insights into the Type II Secretion System of the poly-extremophile Deinococcus radiodurans
Author links open overlay panel, , , , , AbstractThe extremophile bacterium D. radiodurans boasts a distinctive cell envel...
Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen associated carbohydrate motifs
Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen associated carbohydrate motifs
KeywordsFIBCD1crystal structurebinding studieschitininnate immunityficolinshost-pathogen interactionstructural biologyThe ...
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