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The structure of the diheme cytochrome c4 from Neisseria gonorrhoeae reveals multiple contributors to tuning reduction potentials
The structure of the diheme cytochrome c4 from Neisseria gonorrhoeae reveals multiple contributors to tuning reduction potentials
Neisseria gonorrhoeae (Ng) is a human pathogen of growing concern owing to the impact of Ng infections on human health [1,...
A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer
A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer
The mortality rate of ovarian cancer is the highest among all gynecological malignancies [1]. Therapeutic strategies consi...
Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity
Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity
In the context of chemotherapeutic drugs, platinum-based complexes have dominated the scene for decades, remaining among t...
Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity
Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity
Regarding inorganic chemistry, coordination chemistry is at the forefront of innovation and exploration. Since this subfie...
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation
Recognized as the ‘guardian of the genome’, the p53 protein has been an important drug target since its discovery in 1979 ...
Gold(III) complexes with thiosemicarbazone ligands: insights into their cytotoxic effects on lung cancer cells
Gold(III) complexes with thiosemicarbazone ligands: insights into their cytotoxic effects on lung cancer cells
Cancer continues to pose a global threat, underscoring the urgent need for more effective and safer treatment options. Gol...
A novel benzothiazole-based mononuclear platinum(II) complex displaying potent antiproliferative activity in HepG-2 cells via mitochondrial-mediated apoptosis
A novel benzothiazole-based mononuclear platinum(II) complex displaying potent antiproliferative activity in HepG-2 cells via mitochondrial-mediated apoptosis
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths in the world [1]. The HCC incidence is ...
Synthesis and photothermal conversion properties of sandwich N-fused porphyrin rhodium-μ-dichloride dimer complexes: π-extended analog of pentamethylcyclopentadienyl dirhodium(III)-μ-dichloride dimer
Synthesis and photothermal conversion properties of sandwich N-fused porphyrin rhodium-μ-dichloride dimer complexes: π-extended analog of pentamethylcyclopentadienyl dirhodium(III)-μ-dichloride dimer
In the context of their close resemblance to natural enzymatic systems, tetrapyrrole metal complexes, such as heme, chloro...
Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling
Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling
Over the last decades, many efforts have been devoted towards the development of novel therapeutic approaches to treat can...
Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands
Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands
Oral cancer is a particularly serious oral disease. It occurs in the tongue, lips, cheeks, and floor of the mouth. Oral sq...
Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity
Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity
When inhaled, chromate is a well-known mutagen and human carcinogen [1]. Unlike cationic Cr(III) complexes, anionic chroma...
Copper(II) complexes with plumbagin and bipyridines target mitochondria for enhanced chemodynamic cancer therapy
Copper(II) complexes with plumbagin and bipyridines target mitochondria for enhanced chemodynamic cancer therapy
Traditional anti-cancer chemotherapy often has toxic and side effects [[1], [2], [3]]. Therefore, the development of novel...
Structure prediction of physiological bis(amino acidato)copper(II) species in aqueous solution: The copper(II) compounds with l-glutamine and l-histidine
Structure prediction of physiological bis(amino acidato)copper(II) species in aqueous solution: The copper(II) compounds with l-glutamine and l-histidine
Copper is both essential and toxic metal for living systems. As an essential trace element, copper participates in physiol...
Structural motifs in the early metallation steps of Zn(II) and Cd(II) binding to apo-metallothionein 1a
Structural motifs in the early metallation steps of Zn(II) and Cd(II) binding to apo-metallothionein 1a
Metals are involved in many physiological processes, with many proteins requiring a metal cofactor to perform their functi...
Chemistry meets biology in the coordination dynamics of metalloproteins
Chemistry meets biology in the coordination dynamics of metalloproteins
At least 30% of proteins contain a metal ion for catalysis, structure, or regulation. In addition to these roles of metal ...
Structural and biophysical properties of a [4Fe4S] ferredoxin-like protein from Synechocystis sp. PCC 6803 with a unique two domain structure
Structural and biophysical properties of a [4Fe4S] ferredoxin-like protein from Synechocystis sp. PCC 6803 with a unique two domain structure
In photosynthetic organisms, the process of electron transfer is fundamental for converting solar energy into electrochemi...
Nitrobindin versus myoglobin: A comparative structural and functional study
Nitrobindin versus myoglobin: A comparative structural and functional study
KeywordsNitrobindinMyoglobinStructureFunctionSpectroscopic propertiesRNS and ROS detoxificationAbbreviationsAt-Nb(II)ferro...
Jonathan B. Wittenberg (1923–2023)
Jonathan B. Wittenberg (1923–2023)
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Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain
Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain
Globins are small respiratory proteins present in all kingdoms of life that, via their haem prosthetic group, can bind O2 ...
Heme is pivotal for life
Heme is pivotal for life
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Molecular analysis of the human cytoglobin mRNA isoforms
Molecular analysis of the human cytoglobin mRNA isoforms
Cytoglobin (Cygb) [1,2] is a highly conserved member of the vertebrate globin superfamily, which includes respiratory meta...
DFT mechanistic study of biomimetic diiron complex catalyzed dehydrogenation: Unexpected Fe(III)Fe(III)-1,1-μ-hydroperoxy active species for hydride abstraction
DFT mechanistic study of biomimetic diiron complex catalyzed dehydrogenation: Unexpected Fe(III)Fe(III)-1,1-μ-hydroperoxy active species for hydride abstraction
The diiron active site plays a crucial role in the transport and activation of oxygen in biological systems [[1], [2], [3]...
Cyclometalated iridium(III) complexes as anti-breast cancer and anti-metastasis agents via STAT3 inhibition
Cyclometalated iridium(III) complexes as anti-breast cancer and anti-metastasis agents via STAT3 inhibition
Breast cancer (BC) is responsible for the majority of cancer-related deaths in women. Patients with primary breast cancer ...
Ruthenium(II) polypyridyl complexes as emerging photosensitisers for antibacterial photodynamic therapy
Ruthenium(II) polypyridyl complexes as emerging photosensitisers for antibacterial photodynamic therapy
Antibiotic resistance is referred to as one of the biggest threats to the modern healthcare system because of the scale an...
Novel diphenyltin(IV) complexes with carboxylato N-functionalized 2-quinolone ligands: Synthesis, characterization and in vitro anticancer studies
Novel diphenyltin(IV) complexes with carboxylato N-functionalized 2-quinolone ligands: Synthesis, characterization and in vitro anticancer studies
Cancer is among the leading causes of death worldwide, with a devastating statistical rate of nearly ten million deaths in...
Synthesis, structure and biological activity of silver(I) complexes containing triphenylphosphine and non-steroidal anti-inflammatory drug ligands
Synthesis, structure and biological activity of silver(I) complexes containing triphenylphosphine and non-steroidal anti-inflammatory drug ligands
Silver is one of the noble metals, which has been used not only as money, jewelry, ornaments, and kitchen utensils, but al...
Mitochondriotropic agents conjugated with NSAIDs through metal ions against breast cancer cells
Mitochondriotropic agents conjugated with NSAIDs through metal ions against breast cancer cells
Conformational flexibility in inorganic molecules increases the possibility of polymorphism [1]. These polymorphic forms d...
Synthesis, characterization, antiproliferative activity and DNA binding calculation of substituted-phenyl-terpyridine copper(II) nitrate complexes
Synthesis, characterization, antiproliferative activity and DNA binding calculation of substituted-phenyl-terpyridine copper(II) nitrate complexes
Cancer is a common and highly threatening disease, and is one of the main causes of death in today's society. Its etiology...
Structural changes in DNA by binding mitochondrion-targeted monofunctional platinum(II) complexes using molecular dynamics simulation study
Structural changes in DNA by binding mitochondrion-targeted monofunctional platinum(II) complexes using molecular dynamics simulation study
Cancer, the leading reason of death worldwide, is affected by genetic and environmental conditions and defined by uncontro...
Design, synthesis and anticancer evaluation of novel half-sandwich Ru(II) complexes bearing pyrazalone moiety: Apoptosis inducers based on mitochondrial dysfunction and G0/G1 arrest
Design, synthesis and anticancer evaluation of novel half-sandwich Ru(II) complexes bearing pyrazalone moiety: Apoptosis inducers based on mitochondrial dysfunction and G0/G1 arrest
Cancer significantly threatens global health, with projections estimating a rise to 28.4 million cases worldwide by 2040 [...
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