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Epigenetic regulation of cancer
Epigenetic regulation of cancer
Volume 383, 2024, Pages xi-xvAuthor links open overlay panel, Section snippetsAcknowledgmentsLG is/has been supported (as ...
Chapter One - Epigenetic therapeutic strategies in pancreatic cancer
Chapter One - Epigenetic therapeutic strategies in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has an incidence of 495,773 cases per year worldwide and accounts for 466,003 deat...
Chapter Two - Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications
Chapter Two - Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications
Prostate cancer (PCa) is the second most common malignancy in men worldwide and remains a leading cause of death (Rawla, 2...
Chapter Three - Epigenetic control of cell signalling in cancer stem cells
Chapter Three - Epigenetic control of cell signalling in cancer stem cells
The cancer cells in a tumour mass are highly heterogeneous, consisting of different populations of cells (Meacham and Morr...
Chapter Four - Epigenetic inhibitors for cancer treatment
Chapter Four - Epigenetic inhibitors for cancer treatment
Cancer remains a leading cause of death worldwide. Ten million deaths were caused by cancer in 2020, accounting for 1/6 of...
Chapter Five - Epigenetics as a determinant of radiation response in cancer
Chapter Five - Epigenetics as a determinant of radiation response in cancer
Radiation therapy is a cornerstone of modern cancer therapy. Alongside surgery, chemotherapy and molecularly-targeted ther...
Chapter Six - Epigenome editing in cancer: Advances and challenges for potential therapeutic options
Chapter Six - Epigenome editing in cancer: Advances and challenges for potential therapeutic options
Chromosomes were first identified as carriers of genetic information in 1902 (Satzinger, 2008) and later characterized as ...
Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors
Cancer remains the leading cause of global mortality, prompting a paradigm shift in its treatment and outcomes with the ad...
Exploring TLR signaling pathways as promising targets in cervical cancer: the road less traveled
Exploring TLR signaling pathways as promising targets in cervical cancer: the road less traveled
Cervical cancer is the leading cause of cancer-related deaths for women globally. Despite notable advancements in preventi...
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
The statistical data provided by the Global Burden of Diseases, Injuries, and Risk Factors Study, 2017 suggested that the ...
The crosstalk between miRNAs and signaling pathways in human cancers: Potential therapeutic implications
The crosstalk between miRNAs and signaling pathways in human cancers: Potential therapeutic implications
Cancer stands as a leading global cause of fatalities. The principal hallmark of cancer is the rapid and uncontrolled divi...
Inflammatory breast cancer biomarkers and biology
Inflammatory breast cancer biomarkers and biology
A challenging characteristic of inflammatory breast cancer (IBC) to physicians is the lack of a collective tumor mass. Ins...
Advances in targets in inflammatory breast cancer
Advances in targets in inflammatory breast cancer
AXL receptor tyrosine kinase (also called tyrosine-protein kinase receptor UFO), a member of the tumor-associated macropha...
Deciphering the molecular biology of inflammatory breast cancer through molecular characterization of patient samples and preclinical models
Deciphering the molecular biology of inflammatory breast cancer through molecular characterization of patient samples and preclinical models
Inflammatory breast cancer (IBC) is an aggressive subtype of breast cancer with dismal patient prognosis. Although by some...
Targeting signaling pathways in cancer stem cells: A potential approach for developing novel anti-cancer therapeutics
Targeting signaling pathways in cancer stem cells: A potential approach for developing novel anti-cancer therapeutics
One of the most difficult and deadly diseases that humanity currently faces is cancer. It is a broad and varied collection...
Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review
Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review
Breast cancer (BC) is the cancer type with the highest incidence and mortality in women according to GLOBOCAN 2020 (Sung e...
Cellular signaling in glioblastoma: A molecular and clinical perspective
Cellular signaling in glioblastoma: A molecular and clinical perspective
Glioblastoma multiforme (GBM) is the common term for most gliomas given a CNS WHO Grade IV rating (Brennan et al., 2009, G...
Targeting KRAS and SHP2 signaling pathways for immunomodulation and improving treatment outcomes in solid tumors
Targeting KRAS and SHP2 signaling pathways for immunomodulation and improving treatment outcomes in solid tumors
Available online 20 February 2024Author links open overlay panel, , AbstractHistorically, KRAS has been considered ‘undrug...
An Overview of the Unfolded Protein Response (UPR) and Autophagy Pathways in Human Viral Oncogenesis
An Overview of the Unfolded Protein Response (UPR) and Autophagy Pathways in Human Viral Oncogenesis
Autophagy and Unfolded Protein Response (UPR) can be regarded as the safe keepers of cells exposed to intense stress. Auto...
Inflammatory breast cancer (IBC) advocacy—Past, present and future!
Inflammatory breast cancer (IBC) advocacy—Past, present and future!
Available online 21 November 2023Author links open overlay panel, , , , AbstractPatient advocates, referring to those indi...
Epigenome editing in cancer: Advances and challenges for potential therapeutic options
Epigenome editing in cancer: Advances and challenges for potential therapeutic options
Chromosomes were first identified as carriers of genetic information in 1902 (Satzinger, 2008) and later characterized as ...
Radiation for inflammatory breast cancer: Updates
Radiation for inflammatory breast cancer: Updates
Inflammatory breast cancer (IBC) comprises a small subset of all breast cancer diagnoses in the United States but contribu...
Circulating tumor cells: from biotech innovation to clinical utility
Circulating tumor cells: from biotech innovation to clinical utility
J. Pascual et al.ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: A report from ...
Chapter One - Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer
Chapter One - Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer
The myocardial infarct size can be reduced by pharmacological postconditioning using cardioprotective agents. Neuregulin-1...
Chapter Two - Can we define breast cancer HER2 status by liquid biopsy?
Chapter Two - Can we define breast cancer HER2 status by liquid biopsy?
Breast cancer is the most common type of cancer as well as the first cause of cancer-specific mortality among women worldw...
Chapter Three - Models to study CTCs and CTC culture methods
Chapter Three - Models to study CTCs and CTC culture methods
Cancer is a major public health problem and it remains the leading cause of death worldwide. There were an estimated 18.1 ...
Chapter Four - Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis
Chapter Four - Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis
Circulating tumor cells (CTCs) were first documented by Thomas Ashworth in 1869 (Ashworth, 1869), when he first documented...
Chapter Five - Circulating tumor cells in cancer-risk populations as a cancer interception tool
Chapter Five - Circulating tumor cells in cancer-risk populations as a cancer interception tool
Circulating tumor cells (CTCs) have known prognostic implications in metastatic castration–resistant prostate cancer, but ...
Chapter Six - Circulating tumor cells and host immunity: A tricky liaison
Chapter Six - Circulating tumor cells and host immunity: A tricky liaison
Cancer can affect all human organs and tissues and ranks as a prominent cause of death as well as an obstruction to increa...
Epigenetics as a determinant of radiation response in cancer
Epigenetics as a determinant of radiation response in cancer
Radiation therapy is a cornerstone of modern cancer therapy. Alongside surgery, chemotherapy and molecularly-targeted ther...
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