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Selective inhibition of SIRT2: A disputable therapeutic approach in cancer therapy
Selective inhibition of SIRT2: A disputable therapeutic approach in cancer therapy
Sirtuin (silent information regulator 2-related proteins, SIRT) enzymes belong to a family of nicotinamide adenine dinucle...
Pathology, target discovery, and the evolution of XO inhibitors from the first discovery to recent advances (2020–2023)
Pathology, target discovery, and the evolution of XO inhibitors from the first discovery to recent advances (2020–2023)
Uric acid (UA) is an organic heterocyclic compound with molecular formula of C5H4N4O3. UA is biosynthesized in the liver a...
Recent advances in the synthesis and antimalarial activity of 1,2,4-trioxanes
Recent advances in the synthesis and antimalarial activity of 1,2,4-trioxanes
Malaria has been derived from an Italian word i.e., ‘mal’ ‘area’ which describes ‘bad air’ as the disease is said to be ea...
RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective
RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective
Musashi is a very famous samurai in Japanese culture, but the term has a disparate meaning in biology. In 1994, Craig Mont...
Recent advances of vacuolar protein-sorting 34 inhibitors targeting autophagy
Recent advances of vacuolar protein-sorting 34 inhibitors targeting autophagy
Autophagy, ubiquitous in eukaryotic cells (from yeast to mammals), is an antioxidant response mechanism in cells under oxi...
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy
Cancer is an increasingly severe health issue that affects individuals of all ages. In 2022, it was estimated that there w...
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
Design of tubulin inhibitors as anticancer drugs dynamically developed over the past 20 years. The modern arsenal of poten...
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
Cancer is one of the deadliest diseases that is spreading across the world [1]. Nearly 10 million deaths were reported fro...
Biological activity and structural modification of isosteviol over the past 15 years
Biological activity and structural modification of isosteviol over the past 15 years
Natural products are significant sources of lead compounds and functional organic molecules used in pharmaceuticals. Scree...
C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018–2023)
C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018–2023)
Because of their widespread distribution in natural products and synthesized compounds with potential bioactivities, spiro...
Structural diversity of microbial secondary metabolites based on chemical epigenetic manipulation
Structural diversity of microbial secondary metabolites based on chemical epigenetic manipulation
Natural products from plants and microorganisms play a pivotal role in modern medicine and show a wide range of pharmacolo...
Targeting JAK2/STAT3 for the treatment of cancer: A review on recent advancements in molecular development using structural analysis and SAR investigations
Targeting JAK2/STAT3 for the treatment of cancer: A review on recent advancements in molecular development using structural analysis and SAR investigations
Cancer, often called neoplasms and malignant tumours, is a group of disorders characterized by the uncontrolled division a...
Discovery of α-Ketoamide inhibitors of SARS-CoV-2 main protease derived from quaternized P1 groups
Discovery of α-Ketoamide inhibitors of SARS-CoV-2 main protease derived from quaternized P1 groups
The pandemic of the Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-C...
Penicimides A and B, two novel diels–alder [4 + 2] cycloaddition ergosteroids from Penicillium herquei
Penicimides A and B, two novel diels–alder [4 + 2] cycloaddition ergosteroids from Penicillium herquei
Steroids represent a special class of biomolecules in human beings and other organisms that play significant roles in memb...
Evaluation of antihypertensive activity and molecular docking analysis of Padina boergesenii extract
Evaluation of antihypertensive activity and molecular docking analysis of Padina boergesenii extract
Hypertension often referred to as a silent killer, is commonly asymptomatic in nature thus identified as a common risk fac...
Novel indolinone-tethered benzothiophenes as anti-tubercular agents against MDR/XDR M. tuberculosis: Design, synthesis, biological evaluation and in vivo pharmacokinetic study
Novel indolinone-tethered benzothiophenes as anti-tubercular agents against MDR/XDR M. tuberculosis: Design, synthesis, biological evaluation and in vivo pharmacokinetic study
Being one of the deadliest contagious diseases worldwide, tuberculosis (TB) is accounted as one of the threatening health ...
Design, synthesis, and evaluation of pirfenidone-NSAIDs conjugates for the treatment of idiopathic pulmonary fibrosis
Design, synthesis, and evaluation of pirfenidone-NSAIDs conjugates for the treatment of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal, chronic and progressive lung disease characterized by excessive inflammato...
Synthesis, in vitro, and in silico studies of new derivatives of diphenylpiperazine scaffold: A key substructure for MAO inhibition
Synthesis, in vitro, and in silico studies of new derivatives of diphenylpiperazine scaffold: A key substructure for MAO inhibition
Fifteen new diphenylpiperazine hybrids were designed, synthesized and in vitro biologically evaluated against hMAOs enzyme...
Evaluation of a biomarker (NO) dynamics in inflammatory zebrafish and periodontitis saliva samples via a fast-response and sensitive fluorescent probe
Evaluation of a biomarker (NO) dynamics in inflammatory zebrafish and periodontitis saliva samples via a fast-response and sensitive fluorescent probe
Nitric oxide (NO) is an important biologically active gas that is synthesized in the human body through the catalytic acti...
Panaxadiol carbamate derivatives: Synthesis and biological evaluation as potential multifunctional anti-Alzheimer agents
Panaxadiol carbamate derivatives: Synthesis and biological evaluation as potential multifunctional anti-Alzheimer agents
Alzheimer's Disease (AD) was first discovered and reported by a German doctor in 1906 [1]. It is the most common neurodege...
New resveratrol analogs as improved biologically active structures: Design, synthesis and computational modeling
New resveratrol analogs as improved biologically active structures: Design, synthesis and computational modeling
To find new molecules that would retain structural stability and excellent therapeutic properties, great attention is paid...
Structurally diverse amides from Chloranthus henryi var. hupehensis and their anti-inflammatory activities by blocking Akt phosphorylation
Structurally diverse amides from Chloranthus henryi var. hupehensis and their anti-inflammatory activities by blocking Akt phosphorylation
The genus Chloranthus (Chloranthaceae) consists of 13 species and 5 varieties, which are mainly distributed in the eastern...
Molecular hybrids of substituted phenylcarbamoylpiperidine and 1,2,4-triazole methylacetamide as potent 15-LOX inhibitors: Design, synthesis, DFT calculations and molecular docking studies
Molecular hybrids of substituted phenylcarbamoylpiperidine and 1,2,4-triazole methylacetamide as potent 15-LOX inhibitors: Design, synthesis, DFT calculations and molecular docking studies
Inflammation is a protracted evolved process linked with the activation, recruitment, and efficiency of innate as well as ...
Design, synthesis, and biological evaluation of novel donepezil-tacrine hybrids as multi-functional agents with low neurotoxicity against Alzheimer’s disease
Design, synthesis, and biological evaluation of novel donepezil-tacrine hybrids as multi-functional agents with low neurotoxicity against Alzheimer’s disease
Alzheimer’s disease (AD) is the most common type of dementia syndrome typically affecting individuals over the age of 65. ...
Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications
Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications
Nicotinamide N-methyltransferase (NNMT) is a methyltransferase that is highly expressed in the human liver and adipose tis...
Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma
Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma
Uveal melanoma (UM) represents a prevalent form of intraocular malignant tumor in adults, accounting for approximately 5 %...
Deciphering single-cell protein secretion and gene expressions by constructing cell-antibody conjugates
Deciphering single-cell protein secretion and gene expressions by constructing cell-antibody conjugates
Secreted proteins serve as pivotal messengers of intricate intercellular interactions. These proteins govern a spectrum of...
A highly oxidized germacranolide from elephantopus tomentosus inhibits the growth of hepatocellular carcinoma cells by targeting EGFR in vitro and in vivo
A highly oxidized germacranolide from elephantopus tomentosus inhibits the growth of hepatocellular carcinoma cells by targeting EGFR in vitro and in vivo
Primary liver cancer is the sixth most commonly diagnosed cancer worldwide and the third leading cause of cancer deaths in...
Potential therapeutic medicines for renal fibrosis: Small-molecule compounds and natural products
Potential therapeutic medicines for renal fibrosis: Small-molecule compounds and natural products
Chronic kidney disease (CKD) is regarded as a progressive disease, whose main pathological features are excessive depositi...
Synthesis and application of clinically approved small-molecule drugs targeting androgen receptor
Synthesis and application of clinically approved small-molecule drugs targeting androgen receptor
Androgen Receptors (AR) constitute an essential nuclear hormone receptor situated within the steroid receptor superfamily....
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