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Identification of crucial pathways and genes linked to endoplasmic reticulum stress in PCOS through combined bioinformatic analysis
1 BackgroundPolycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder among women of reproductive age, aff...
Recent advances of lysine lactylation in prokaryotes and eukaryotes
1 IntroductionLysine lactylation is an emerging post-translational modification (PTM) that influences a variety of cellula...
Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study
1 IntroductionBreast cancer (BCa) is the most prevalent cancer among women worldwide and a leading cause of death. In 2020...
Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology
1 IntroductionThe human intestinal epithelium functions as a critical interface between the body and external environment,...
First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls
IntroductionGestational diabetes mellitus (GDM) defined as hyperglycemia first recognised in pregnancy (World Health Organ...
Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines
1 IntroductionColorectal cancer (CRC) is one of the most prevalent and deadly cancers worldwide, accounting for approximat...
Plasma proteome fingerprint in kidney diseases
1 IntroductionUnderstanding the molecular foundations of disease development opens up new opportunities for designing nove...
Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis
IntroductionMelanoma is an aggressive and highly lethal form of skin cancer, responsible for around 60%–70% of all skin ca...
Editorial: Metabolomics and transcriptomics in biomarker discovery: mass spectrometric techniques in volatilome research
The central dogma of molecular biology traces a path from genomic sequence information represented in DNA to transcribed m...
Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes
1 IntroductionHypertension in children is an increasingly recognized public health concern, with an estimated prevalence r...
Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study
IntroductionOvarian cancer is one of the most common and lethal malignancy of the female reproductive system (Cortez et al...
Editorial: Oncolytic virotherapy, volume II
Oncolytic Virotherapy (OV) is continuing to evolve rapidly, with one oncolytic herpes simplex virus (HSV) clinically appro...
Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples
IntroductionClinical relevance of fusion genesFusion genes are frequently found in cancer cell genomes (Li et al., 2023; S...
Labeling tumor-associated extracellular vesicles with antibody-DNA conjugates for quantitative analysis
1 IntroductionExtracellular vesicles (EVs) are membrane-coated nanometer-sized vesicles released by cells into the bloodst...
Melanoma-derived cytokines and extracellular vesicles are interlinked with macrophage immunosuppression
1 IntroductionThe current understanding of the immune landscape in cutaneous melanoma depicts it as an immunogenic maligna...
Diagnostic potential of CDK1 and STAT1 in acute kidney injury associated with gastrointestinal cancers: a bioinformatics-based study
1 Introduction Gastrointestinal cancers, including esophageal, gastric, and colorectal cancers, represent a signif...
Retraction: ZFP36 binds with PRC1 to inhibit tumor growth and increase 5-Fu chemosensitivity of hepatocellular carcinoma
Please find the retraction statement below:Chen W, Chen M, Zhao Z, Weng Q, Song J, Fang S, Wu X, Wang H, Zhang D, Yang W, ...
Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer
IntroductionThe tumor endothelial marker 8 (TEM8) or anthrax receptor 1 (ANTXR1) is a protein that is encoded by the ANTXR...
Linking machine learning and biophysical structural features in drug discovery
1 IntroductionContemporary approaches in computational drug discovery and computational chemical biology are mostly center...
Aqueous humor metabolomic profiling identifies a distinct signature in pseudoexfoliation syndrome
1 IntroductionFinnish ophthalmologist John Gustaf Lindberg presented the first description of pseudoexfoliation syndrome (...
Formation of dsRNA by-products during in vitro transcription can be reduced by using low steady-state levels of UTP
Formation of dsRNA by-products during in vitro transcription can be reduced by using low steady-state levels of UTP
Introduction: Exogeneous messenger ribonucleic acid (mRNA) can be used as therapeutic and preventive medication. However, ...
Editorial: Molecular determinants of protein assemblies in health and disease, Volume II
Editorial: Molecular determinants of protein assemblies in health and disease, Volume II
that underlie the production, reversibility, and turnover of dynamic biomolecular condensates and static protein aggregate...
A prognostic model based on prognosis-related ferroptosis genes for patients with acute myeloid leukemia
A prognostic model based on prognosis-related ferroptosis genes for patients with acute myeloid leukemia
Background: Acute myeloid leukemia (AML) is a heterogeneous disorder with an unpredictable prognosis. Ferroptosis, the iro...
The elucidation of the multimodal action of the investigational anti-Candida lipopeptide (AF4) lead from Bacillus subtilis
The elucidation of the multimodal action of the investigational anti-Candida lipopeptide (AF4) lead from Bacillus subtilis
Background:Candida species are the main etiological agents for candidiasis, and Candida albicans are the most common infec...
Crosstalk of ferroptosis and oxidative stress in infectious diseases
Crosstalk of ferroptosis and oxidative stress in infectious diseases
Ferroptosis is a type of programmed cell death that pathogens can leverage to enhance their replication, transmission, and...
Evidence of DISC1 as an arsenic binding protein and implications regarding its role as a translational activator
Evidence of DISC1 as an arsenic binding protein and implications regarding its role as a translational activator
Disrupted-in-schizophrenia-1 (DISC1) is a scaffolding protein that plays a pivotal role in orchestrating signaling pathway...
Tools and tactics to define specificity of metabolic chemical reporters
Tools and tactics to define specificity of metabolic chemical reporters
Metabolic chemical reporters (MCRs) provide easily accessible means to study glycans in their native environments. However...
ASCA-related antibodies in the blood sera of healthy donors and patients with colorectal cancer: characterization with oligosaccharides related to Saccharomyces cerevisiae mannan
ASCA-related antibodies in the blood sera of healthy donors and patients with colorectal cancer: characterization with oligosaccharides related to Saccharomyces cerevisiae mannan
Mannans are polysaccharide antigens expressed on the cell wall of different fungal species including Saccharomyces cerevis...
Misfolding of fukutin-related protein (FKRP) variants in congenital and limb girdle muscular dystrophies
Misfolding of fukutin-related protein (FKRP) variants in congenital and limb girdle muscular dystrophies
Fukutin-related protein (FKRP, MIM ID 606596) variants cause a range of muscular dystrophies associated with hypo-glycosyl...
Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort
Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort
Type 2 diabetes mellitus (T2DM) can be multifactorial where both genetics and environmental factors play a role. We aimed ...
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