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HDL, heart disease, and the lung
Abbreviations: ASCVD (atherosclerotic cardiovascular diseases), DPPC (dipalmitoylphosphatidylcholine)For more than 50 year...
Validation of a multiplexed and targeted lipidomics assay for accurate quantification of lipidomes
AbstractA major challenge of lipidomics is to determine and quantify the precise content of complex lipidomes to the exact...
Heptanol-mediated phase separation determines phase preference of molecules in live cell membranes
AbstractThe localization of many membrane proteins within cholesterol- and sphingolipid-containing microdomains is essenti...
Neuronal growth regulator 1 promotes adipocyte lipid trafficking via interaction with CD36
AbstractNeuronal growth regulator 1 (NEGR1) is a glycosylphosphatidylinositol-anchored membrane protein associated with se...
Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer
Although seemingly banal, the structure-function relationship of glycerophospholipid (GPL) is far more complex and insight...
Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown
AbstractLittle is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cle...
The effects of cardiolipin on the structural dynamics of the mitochondrial ADP/ATP carrier in its cytosol-open state
AbstractCardiolipin (CL) has been shown to play a crucial role in regulating the function of proteins in the inner mitocho...
ω-O-Acylceramides but not ω-hydroxy ceramides are required for healthy lamellar phase architecture of skin barrier lipids
AbstractEpidermal omega-O-acylceramides (ω-O-acylCers) are essential components of a competent skin barrier. These unusual...
Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling
Sphingolipids, a major lipid class in eukaryotic cells, are characterized by a sphingoid base backbone, often 18-carbon sp...
Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species
Synthesis was conducted as previously described with modifications (19Valenzano C.R. You Y.O. Garg A. Keatinge-Clay A. Kho...
Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome
Abstract7-dehydrocholesterol (7-DHC) and cholesterol (CHOL) are biomarkers of Smith-Lemli-Opitz Syndrome (SLOS), a congeni...
Development and Validation of an Isoform Independent Monoclonal Antibody-Based ELISA for Measurement of Lipoprotein(a)
INTRODUCTIONLipoprotein(a) [Lp(a)] is an apo B-containing lipoprotein that is a genetic, independent risk factor for cardi...
Sorting Through the Extensive and Confusing Roles of Sortilin in Metabolic Disease
Petersen C.M. Nielsen M.S. Nykjaer A. Jacobsen L. Tommerup N. Rasmussen H.H. et al.Molecular identification of a novel can...
Elevated lipoprotein(a) as a predictor for coronary events in older men
IntroductionElevated circulating lipoprotein(a) (Lp(a)) is associated with an increased risk of first and recurrent cardio...
The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes
INTRODUCTIONAn elevated level of circulating low-density lipoprotein (LDL) cholesterol is a major risk factor for atherosc...
Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina
IntroductionPhosphatidic acid (PtdOH) is a multi-functional lipid second messenger heavily implicated in membrane fusion i...
Elevated de novo lipogenesis, slow liver triglyceride turnover and clinical correlations in nonalcoholic steatohepatitis patients
ABSTRACTDe novo lipogenesis (DNL) converts carbon substrates to lipids. Increased hepatic DNL could contribute to pathogen...
Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain
IntroductionIntact cholesterol biosynthesis is crucial for CNS homeostasis. The brain contains approximately 20-25% of all...
CrrAB regulates PagP-mediated glycerophosphoglycerol palmitoylation in the outer membrane of Klebsiella pneumoniae
1. IntroductionGram-negative bacteria have a complex cell envelope consisting of an inner membrane (IM), a thin peptidogly...
Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation
AbstractPlasmalogens are membrane glycerophospholipids with diverse biological functions. Reduced plasmalogen levels have ...
PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high fat diet conditions
3. IntroductionSedentary lifestyle(1Biswas A. Oh P.I. Faulkner G.E. Bajaj R.R. Silver M.A. Mitchell M.S. Alter D.A. Sedent...
The role of full-length apoE in clearance of Gram-negative bacteria and their endotoxins
ApoE, a 34 kDa heterodimeric glycoprotein, is a well-known lipid-binding protein that plays a main role in the metabolism ...
Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver
IntroductionLiver is an important organ in maintaining whole-body cholesterol homeostasis by mediating cholesterol synthes...
Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions
 Precursor scanning of human epidermal extracts identifies a series of ceramides that contain LAHuman epidermal extracts w...
The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1
AbstractNuclear receptors are transcription factors that bind lipids, an event that induces a structural conformation of t...
Proteoglycan binding as proatherogenic function metric of apoB-containing lipoproteins and chronic kidney graft failure
Atherosclerosis negatively impacts the prognosis of renal transplant recipients (RTRs) in two ways, (i) in the form of pre...
The role of full-length apolipoprotein E in clearance of Gram-negative bacteria and their endotoxins
IntroductionApolipoprotein E (apoE), a 34 kDa hetero-dimeric glycoprotein, is a well-known lipid-binding protein that play...
Analysis of 12/15-lipoxygenase metabolism of EPA and DHA with special attention to authentication of docosatrienes
AbstractA proposed beneficial impact of highly unsaturated “fish oil” fatty acids is their conversion by lipoxygenase (LOX...
Monomeric bile acids modulate the ATPase activity of detergent-solubilized ABCB4/MDR3
IntroductionHuman bile, which is formed at the canalicular membrane of hepatocytes, consists mainly of mixed micelles form...
The Lipid Biology of Sepsis
Rudd K.E. Johnson S.C. Agesa K.M. Shackelford K.A. Tsoi D. Kievlan D.R. Colombara D.V. Ikuta K.S. Kissoon N. Finfer S. Fle...
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