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The pro‐proliferative effect of insulin in human breast epithelial DMBA‐transformed and non‐transformed cell lines is PI3K‐, mTOR‐ and GLUT1‐dependent
The pro‐proliferative effect of insulin in human breast epithelial DMBA‐transformed and non‐transformed cell lines is PI3K‐, mTOR‐ and GLUT1‐dependent
Type 2 diabetes mellitus (T2DM) is linked to an increased risk of breast cancer. We aimed to investigate how T2DM-associat...
Interaction of membrane‐embedded cytochrome b‐complexes with quinols: Classical Q‐cycle and murburn model
Interaction of membrane‐embedded cytochrome b‐complexes with quinols: Classical Q‐cycle and murburn model
We recently proposed a diffusible reactive (oxygen) species (DRS/DROS) based function for cytochrome b complexes (CBC) and...
Pharmacological inhibition of UPR sensor PERK attenuates HIV Tat‐induced inflammatory M1 phenotype in microglial cells
Pharmacological inhibition of UPR sensor PERK attenuates HIV Tat‐induced inflammatory M1 phenotype in microglial cells
HIV-1-associated neurocognitive disorders (HAND) are a major concern in HIV-infected individuals despite the currently ava...
Vanillin attenuates thioacetamide‐induced renal assault by direct and indirect mediation of the TGFβ, ERK and Smad signalling pathways in rats
Vanillin attenuates thioacetamide‐induced renal assault by direct and indirect mediation of the TGFβ, ERK and Smad signalling pathways in rats
Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD). Renal fibrosis is considered to b...
Telomerase‐based therapies in haematological malignancies
Telomerase‐based therapies in haematological malignancies
Telomeres are specialized genetic structures present at the end of all eukaryotic linear chromosomes. They progressively g...
Improved biological behaviours and osteoinductive capacity of the gelatin nanofibers while composites with GO/MgO
Improved biological behaviours and osteoinductive capacity of the gelatin nanofibers while composites with GO/MgO
Among the many polymers introduced for bone tissue engineering, natural polymers have more advantages due to their high bi...
Retraction statement: MicroRNA‐4328 promotes lens epithelial cell apoptosis by targeting NLR family, apoptosis inhibitory protein in age‐related cataract
Retraction statement: MicroRNA‐4328 promotes lens epithelial cell apoptosis by targeting NLR family, apoptosis inhibitory protein in age‐related cataract
Retraction: “MicroRNA-4328 promotes lens epithelial cell apoptosis by targeting NLR family, apoptosis inhibitory protein i...
Combined effect of polyacrylic acid and vitamin E in preventing calcium oxalate crystal deposition in the kidneys of experimental hyperoxaluric rats
Combined effect of polyacrylic acid and vitamin E in preventing calcium oxalate crystal deposition in the kidneys of experimental hyperoxaluric rats
Our study explores the combined effect of polyacrylic acid and vitamin E as prophylactic and curative agent against ethyle...
Constitutive activation of Notch signalling and T cell activation characterize a mouse model of autism
Constitutive activation of Notch signalling and T cell activation characterize a mouse model of autism
Gene and protein expression of BTBR T+ Itpr3tf/J (BTBR) mice with autistic-like behaviours were compared with the C57BL/6J...
The role of fatty acid amide hydrolase enzyme inhibitors in Alzheimer's disease
The role of fatty acid amide hydrolase enzyme inhibitors in Alzheimer's disease
Fatty acid amide hydrolase (FAAH) is a prominent enzyme of the endocannabinoid system that degrades endogenous cannabinoid...
Advances on biological functions of exosomal non‐coding RNAs in osteoarthritis
Advances on biological functions of exosomal non‐coding RNAs in osteoarthritis
Exosomes can be secreted by various cells and function as intercellular communication vehicles by delivering specific carg...
Gene therapy: A promising approach for breast cancer treatment
Gene therapy: A promising approach for breast cancer treatment
Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death among women worldwide that is ca...
MEK1 activation enhances the ex vivo proliferation of haematopoietic stem/progenitor cell
MEK1 activation enhances the ex vivo proliferation of haematopoietic stem/progenitor cell
Haematopoietic stem/progenitor cell (HSPC) integrates intracellular signal network from growth factors (GFs) and utilizes ...
Antidiabetic effects of quercetin and liraglutide combination through modulation of TXNIP/IRS‐1/PI3K pathway
Antidiabetic effects of quercetin and liraglutide combination through modulation of TXNIP/IRS‐1/PI3K pathway
The study was designed to assess the possible augmented antidiabetic effects of combining quercetin and liraglutide in a t...
The protective effect of metformin against testicular damage in diabetes and prostate cancer model
The protective effect of metformin against testicular damage in diabetes and prostate cancer model
Individuals with diabetes have an increased risk of breast, colorectal, pancreatic and prostate cancer. Metformin, an oral...
Oxidative stress‐A direct bridge to central nervous system homeostatic dysfunction and Alzheimer's disease
Oxidative stress‐A direct bridge to central nervous system homeostatic dysfunction and Alzheimer's disease
Neurologists have highly observed a frequent increasing number of elderly patients with Alzheimer's disease (AD) without a...
microRNAs in female infertility: An overview
microRNAs in female infertility: An overview
Infertility impacts a considerable number of women worldwide, and it affects different aspects of family life and society....
Dieckol induces cell cycle arrest by down‐regulating CDK2/cyclin E in response to p21/p53 activation in human tracheal fibroblasts
Dieckol induces cell cycle arrest by down‐regulating CDK2/cyclin E in response to p21/p53 activation in human tracheal fibroblasts
The phlorotannin derivative dieckol isolated from Ecklonia cava has been shown to exhibit anti-inflammatory, anti-bacteria...
Melatonin: A smart molecule in the DNA repair system
Melatonin: A smart molecule in the DNA repair system
DNA repair is an important pathway for the protection of DNA molecules from destruction. DNA damage can be produced by oxi...
The critical role of mesenchymal stromal/stem cell therapy in COVID‐19 patients: An updated review
The critical role of mesenchymal stromal/stem cell therapy in COVID‐19 patients: An updated review
New coronavirus disease 2019 (COVID-19), as a pandemic disaster, has drawn the attention of researchers in various fields ...
Phenolic compounds as antidiabetic, anti‐inflammatory, and anticancer agents and improvement of their bioavailability by liposomes
Phenolic compounds as antidiabetic, anti‐inflammatory, and anticancer agents and improvement of their bioavailability by liposomes
Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro-oxida...
Angiogenesis induction in breast cancer: A paracrine paradigm
Angiogenesis induction in breast cancer: A paracrine paradigm
Breast cancer is the most prevalent type of cancer among women globally. Angiogenesis contributes significantly to breast ...
Menstrual blood CD146+ mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure
Menstrual blood CD146+ mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure
Here, the regenerative potential of menstrual blood–derived mesenchymal stem cells (MenSCs) was examined on restora...
Sulindac and vitamin D3 synergically inhibit proliferation of MCF‐7 breast cancer cell through AMPK/Akt/β‐catenin axis in vitro
Sulindac and vitamin D3 synergically inhibit proliferation of MCF‐7 breast cancer cell through AMPK/Akt/β‐catenin axis in vitro
Breast cancer is associated with a high rate of recurrence, resistance therapy and mortality worldwide. We aimed at invest...
Isolation of the canine inhibin βB subunit gene and characterization of signalling mediated by canine inhibin βB
Isolation of the canine inhibin βB subunit gene and characterization of signalling mediated by canine inhibin βB
Activin B, a homodimer of the inhibin βB subunit, acts as a regulator of gonadal function and as an adipokine. To cl...
Labelling of human Wharton's jelly‐derived mesenchymal stem cells with gold nanorods by biomimicry method
Labelling of human Wharton's jelly‐derived mesenchymal stem cells with gold nanorods by biomimicry method
Mesenchymal stem cell (MSC)-based cell therapy can provide opportunities for the treatment of various diseases. However, w...
S100A6 represses Calu‐6 lung cancer cells growth via inhibiting cell proliferation, migration, invasion and enhancing apoptosis
S100A6 represses Calu‐6 lung cancer cells growth via inhibiting cell proliferation, migration, invasion and enhancing apoptosis
S100 calcium binding protein A6 (S100A6) has been reported to involve in many kinds of cancers through regulating intracel...
Demethyleneberberine promotes apoptosis and suppresses TGF‐β/Smads induced EMT in the colon cancer cells HCT‐116
Demethyleneberberine promotes apoptosis and suppresses TGF‐β/Smads induced EMT in the colon cancer cells HCT‐116
Colorectal cancer (CRC) is one of the most common malignant tumours in the world. Recent reports have revealed natural pro...
CNTs‐CaP/chitosan‐coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway
CNTs‐CaP/chitosan‐coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway
Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuro...
Metformin suppresses self‐renewal and stemness of cancer stem cell models derived from pluripotent stem cells
Metformin suppresses self‐renewal and stemness of cancer stem cell models derived from pluripotent stem cells
Metformin exhibits anti-cancer activities in various types of tumours while it is prescribed as the first-line drug for ty...
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