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Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Obesity is characterized by chronic low-grade inflammation, which is driven by macrophage infiltration in adipose tissue a...
Mfsd7b facilitates choline transport and missense mutations affect choline transport function
Mfsd7b facilitates choline transport and missense mutations affect choline transport function
MFSD7b belongs to the Major Facilitator Superfamily of transporters that transport small molecules. Two isoforms of MFSD7b...
The senescent mesothelial matrix accentuates colonization by ovarian cancer cells
The senescent mesothelial matrix accentuates colonization by ovarian cancer cells
Ovarian cancer is amongst the most morbid of gynecological malignancies due to its diagnosis at an advanced stage, a trans...
Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids
Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids
Apolipoproteins co-deposit with amyloids, yet apolipoprotein–amyloid interactions are enigmatic. To understand how a...
CCDC146 is required for sperm flagellum biogenesis and male fertility in mice
CCDC146 is required for sperm flagellum biogenesis and male fertility in mice
Multiple morphological abnormalities of the flagella (MMAF) is a severe disease of male infertility, while the pathogeneti...
Polymorphic USP8 allele promotes Parkinson’s disease by inducing the accumulation of α-synuclein through deubiquitination
Polymorphic USP8 allele promotes Parkinson’s disease by inducing the accumulation of α-synuclein through deubiquitination
Parkinson’s disease (PD) is one of the most common neuro-degenerative diseases characterized by α-synuclein acc...
Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system
Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system
The lymphatic vasculature plays a crucial role in fluid clearance and immune responses in peripheral organs by connecting ...
Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division
Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division
The aim of this review article is to focus on the unconventional roles of epigenetic players (chromatin remodelers and lon...
SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
Evasion and antagonism of host cellular immunity upon SARS-CoV-2 infection provide replication advantage to the virus and ...
Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s Disease
Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s Disease
Huntington's Disease (HD) is a disorder that affects body movements. Altered glutamatergic innervation of the striatum...
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons
Recent findings suggest an important role for the dysregulation of stromal interaction molecule (STIM) proteins, activator...
Exploring the link between hedonic overeating and prefrontal cortex dysfunction in the Ts65Dn trisomic mouse model
Exploring the link between hedonic overeating and prefrontal cortex dysfunction in the Ts65Dn trisomic mouse model
Individuals with Down syndrome (DS) have a higher prevalence of obesity compared to the general population. Conventionally...
BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation
BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation
Mutations of large conductance Ca2+- and voltage-activated K+ channels (BK) are associated with cognitive impairment. Here...
Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina
Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina
Inherited retinal dystrophies are often associated with mutations in the genes involved in the phototransduction cascade i...
Combined RNA interference and gene replacement therapy targeting MFN2 as proof of principle for the treatment of Charcot–Marie–Tooth type 2A
Combined RNA interference and gene replacement therapy targeting MFN2 as proof of principle for the treatment of Charcot–Marie–Tooth type 2A
Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein essential for mitochondrial networking in most cells. Autoso...
Cordycepin delays postovulatory aging of oocytes through inhibition of maternal mRNAs degradation via DCP1A polyadenylation suppression
Cordycepin delays postovulatory aging of oocytes through inhibition of maternal mRNAs degradation via DCP1A polyadenylation suppression
Postovulatory aging leads to the decline in oocyte quality and subsequent impairment of embryonic development, thereby red...
E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation
E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation
Faithful chromosome segregation requires correct attachment of kinetochores with the spindle microtubules. Erroneously-att...
The secreted peptide BATSP1 promotes thermogenesis in adipocytes
The secreted peptide BATSP1 promotes thermogenesis in adipocytes
Although brown adipose tissue (BAT) has historically been viewed as a major site for energy dissipation through thermogene...
Interleukin 4 improved adipose-derived stem cells engraftment via interacting with fibro/adipogenic progenitors in dystrophic mice
Interleukin 4 improved adipose-derived stem cells engraftment via interacting with fibro/adipogenic progenitors in dystrophic mice
Adipose-derived stem cells (ADSC) therapy shows promise as an effective treatment for dystrophinopathy. Fibro-/adipogenic ...
Disruption of cholangiocyte-B cell crosstalk by blocking the CXCL12-CXCR4 axis alleviates liver fibrosis
Disruption of cholangiocyte-B cell crosstalk by blocking the CXCL12-CXCR4 axis alleviates liver fibrosis
B cells can promote liver fibrosis, but the mechanism of B cell infiltration and therapy against culprit B cells are lacki...
Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain
Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain
A common perception in age-related neurodegenerative diseases posits that a decline in proteostasis is key to the accumula...
GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation
GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation
Mitochondrial translation occurs on the mitochondrial ribosome, also known as the mitoribosome. The assembly of mitoriboso...
Molecular basis of retinal remodeling in a zebrafish model of retinitis pigmentosa
Molecular basis of retinal remodeling in a zebrafish model of retinitis pigmentosa
A hallmark of inherited retinal degenerative diseases such as retinitis pigmentosa (RP) is progressive structural and func...
Exploring the therapeutic potential of ADC combination for triple-negative breast cancer
Exploring the therapeutic potential of ADC combination for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer. Currently, standard treatment option...
MiR-326-mediated overexpression of NFIB offsets TGF-β induced epithelial to mesenchymal transition and reverses lung fibrosis
MiR-326-mediated overexpression of NFIB offsets TGF-β induced epithelial to mesenchymal transition and reverses lung fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is a progressively fatal and incurable disease characterized by the loss of alveolar s...
Protein aggregates act as a deterministic disruptor during bacterial cell size homeostasis
Protein aggregates act as a deterministic disruptor during bacterial cell size homeostasis
Mechanisms underlying deviant cell size fluctuations among clonal bacterial siblings are generally considered to be crypti...
Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors
Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors
Increasing evidence implicates astrocytic dysfunction in Alzheimer’s disease (AD), a neurodegenerative disorder char...
Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony
Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony
Arsenic and antimony are metalloids with profound effects on biological systems and human health. Both elements are toxic ...
SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing
SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing
Granulosa cell abnormalities are characteristics of premature ovarian insufficiency (POI). Abnormal expression of serine/a...
Regulation of Atg8 membrane deconjugation by cysteine proteases in the malaria parasite Plasmodium berghei
Regulation of Atg8 membrane deconjugation by cysteine proteases in the malaria parasite Plasmodium berghei
During macroautophagy, the Atg8 protein is conjugated to phosphatidylethanolamine (PE) in autophagic membranes. In Apicomp...
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