Bell AJ, Bhate MS (1992) Prevalence of overweight and obesity in Down’s syndrome and other mentally handicapped adults living in the community. J Intellect Disabil Res. https://doi.org/10.1111/J.1365-2788.1992.TB00534.X

Article  PubMed  Google Scholar 

Yahia S, El-farahaty RM, El-Hawary AK, El-hussiny MA, Abdel-maseih H, El-Dahtory F, El-Gilany AH (2012) Leptin, insulin and thyroid hormones in a cohort of Egyptian obese Down syndrome children: a comparative study. BMC Endocr Disord. https://doi.org/10.1186/1472-6823-12-22

Article  PubMed  PubMed Central  Google Scholar 

Campos C, Casado Á (2015) Oxidative stress, thyroid dysfunction & Down syndrome. Indian J Med Res 142(2):113–119. https://doi.org/10.4103/0971-5916.164218

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahy J, Shields N, Taylor NF, Dodd KJ (2010) Identifying facilitators and barriers to physical activity for adults with Down syndrome. J Intellect Disabil Res 54(9):795–805. https://doi.org/10.1111/J.1365-2788.2010.01308.X

Article  CAS  PubMed  Google Scholar 

Grammatikopoulou MG, Manai A, Tsigga M, Tsiligiroglou-Fachantidou A, Galli-Tsinopoulou A, Zakas A (2008) Nutrient intake and anthropometry in children and adolescents with Down syndrome–a preliminary study. Dev Neurorehabil 11(4):260–267. https://doi.org/10.1080/17518420802525526

Article  PubMed  Google Scholar 

Nordstrøm M, Paus B, Andersen LF, Kolset SO (2015) Dietary aspects related to health and obesity in Williams syndrome, Down syndrome, and Prader-Willi syndrome. Food Nutr Res 3:59. https://doi.org/10.3402/FNR.V59.25487

Article  Google Scholar 

Corwin RL, Hajnal A (2005) Too much of a good thing: neurobiology of non-homeostatic eating and drug abuse. Physiol Behav 86(1–2):5–8. https://doi.org/10.1016/J.PHYSBEH.2005.06.021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kehagia AA, Murray GK, Robbins TW (2010) Learning and cognitive flexibility: frontostriatal function and monoaminergic modulation. Curr Opin Neurobiol 20(2):199–204. https://doi.org/10.1016/J.CONB.2010.01.007

Article  CAS  PubMed  Google Scholar 

Domingo-Rodriguez L, Ruiz de Azua I, Dominguez E, Senabre E, Serra I, Kummer S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M, Dierssen M, Lutz B, Martín-García E, Maldonado R (2020) A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nat Commun. https://doi.org/10.1038/S41467-020-14458-Y

Article  PubMed  PubMed Central  Google Scholar 

Willeumier KC, Taylor DV, Amen DG (2011) Elevated BMI is associated with decreased blood flow in the prefrontal cortex using SPECT imaging in healthy adults. Obesity (Silver Spring) 19(5):1095–1097. https://doi.org/10.1038/OBY.2011.16

Article  PubMed  Google Scholar 

Maayan L, Hoogendoorn C, Sweat V, Convit A (2011) Disinhibited eating in obese adolescents is associated with orbitofrontal volume reductions and executive dysfunction. Obesity (Silver Spring) 19(7):1382–1387. https://doi.org/10.1038/OBY.2011.15

Article  PubMed  Google Scholar 

Cohen JI, Yates KF, Duong M, Convit A (2011) Obesity, orbitofrontal structure and function are associated with food choice: a cross-sectional study. BMJ Open. https://doi.org/10.1136/BMJOPEN-2011-000175

Article  PubMed  PubMed Central  Google Scholar 

Whittle N, Sartori SB, Dierssen M, Lubec G, Singewald N (2007) Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development. Pediatrics. https://doi.org/10.1542/PEDS.2006-3448

Article  PubMed  Google Scholar 

Pujol J, del Hoyo L, Blanco-Hinojo L, de Sola S, Macià D, Martínez-Vilavella G, Amor M, Deus J, Rodríguez J, Farré M, Dierssen M, de la Torre R (2015) Anomalous brain functional connectivity contributing to poor adaptive behavior in Down syndrome. Cortex 1(64):148–156

Article  Google Scholar 

Del Hoyo L, Xicota L, Langohr K, Sánchez-Benavides G, De Sola S, Cuenca-Royo A, Rodriguez J, Rodríguez-Morató J, Farré M, Dierssen M, De La Torre R (2016) VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome. Front Behav Neurosci. https://doi.org/10.3389/FNBEH.2016.00193

Article  PubMed  PubMed Central  Google Scholar 

Palumbo ML, McDougle CJ (2018) Pharmacotherapy of Down syndrome. Expert Opin Pharmacother 19(17):1875–1889. https://doi.org/10.1080/14656566.2018.1529167

Article  CAS  PubMed  Google Scholar 

Dykens EM, Shah B, Davis B, Baker C, Fife T, Fitzpatrick J (2015) Psychiatric disorders in adolescents and young adults with Down syndrome and other intellectual disabilities. J Neurodev Disord. https://doi.org/10.1186/S11689-015-9101-1

Article  PubMed  PubMed Central  Google Scholar 

Berthoud HR (2012) The neurobiology of food intake in an obesogenic environment. Proc Nutr Soc 71(4):478–487. https://doi.org/10.1017/S0029665112000602

Article  PubMed  PubMed Central  Google Scholar 

Singh M (2014) Mood, food, and obesity. Front Psychol 5:1–35. https://doi.org/10.3389/FPSYG.2014.00925

Article  Google Scholar 

Liu DP, Schmidt C, Billings T, Davisson MT (2003) Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome. Biotechniques 35(6):1170–1180. https://doi.org/10.2144/03356ST02

Article  CAS  PubMed  Google Scholar 

Fructuoso M, Espinosa-Carrasco J, Erb I, Notredame C, Dierssen M (2019) Protocol for measuring compulsive-like feeding behavior in mice. Bio-Protoc. https://doi.org/10.21769/BIOPROTOC.3308

Article  PubMed  PubMed Central  Google Scholar 

Bura SA, Burokas A, Martín-García E, Maldonado R (2010) Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice. Eur Neuropsychopharmacol 20(6):369–378. https://doi.org/10.1016/J.EURONEURO.2010.02.003

Article  CAS  PubMed  Google Scholar 

Paxinos and Franklin’s the Mouse Brain in Stereotaxic Coordinates - George Paxinos, Keith B.J. Franklin - Google Libros. [cited 2022 Dec 11]

Hothorn T, Bretz F, Westfall P (2008) Simultaneous inference in general parametric models. Biom J 50(3):346–363. https://doi.org/10.1002/BIMJ.200810425

Article  PubMed  Google Scholar 

Espinosa-Carrasco J, Burokas A, Fructuoso M, Erb I, Martín-García E, Gutiérrez-Martos M, Notredame C, Maldonado R, Dierssen M (2018) Time-course and dynamics of obesity-related behavioral changes induced by energy-dense foods in mice. Addict Biol 23(2):531–543. https://doi.org/10.1111/ADB.12595

Article  PubMed  Google Scholar 

Heyne A, Kiesselbach C, Sahún I, McDonald J, Gaiffi M, Dierssen M, Wolffgramm J (2009) An animal model of compulsive food-taking behaviour. Addict Biol 14(4):373–383. https://doi.org/10.1111/J.1369-1600.2009.00175.X

Article  PubMed  Google Scholar 

Kim HJ, Lee JH, Yun K, Kim JH (2017) Alterations in striatal circuits underlying addiction-like behaviors. Mol Cells 40(6):379–385. https://doi.org/10.14348/MOLCELLS.2017.0088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carlin J, Hill-Smith TE, Lucki I, Reyes TM (2013) Reversal of dopamine system dysfunction in response to high-fat diet. Obesity (Silver Spring) 21(12):2513–2521. https://doi.org/10.1002/OBY.20374

Article  CAS  PubMed  Google Scholar 

Moreton E, Baron P, Tiplady S, McCall S, Clifford B, Langley-Evans SC, Fone KCF, Voigt JP (2019) Impact of early exposure to a cafeteria diet on prefrontal cortex monoamines and novel object recognition in adolescent rats. Behav Brain Res 2(363):191–198. https://doi.org/10.1016/J.BBR.2019.02.003

Article  Google Scholar 

Wong C, Dwyer J, Holland M (2014) Overcoming weight problems in adults with down syndrome. Nutr Today 49(3):109–119. https://doi.org/10.1097/NT.0000000000000029

Article  Google Scholar 

Fructuoso M, Rachdi L, Philippe E, Denis RG, Magnan C, Le Stunff H, Janel N, Dierssen M (2018) Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome. Free Radic Biol Med 1(114):122–130. https://doi.org/10.1016/J.FREERADBIOMED.2017.09.021

Article  Google Scholar 

La Fleur SE, Luijendijk MCM, Van Der Zwaal EM, Brans MAD, Adan RAH (2014) The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns. Int J Obes (Lond) 38(5):643–649. https://doi.org/10.1038/IJO.2013.159

Article  PubMed  Google Scholar 

Smith CH, Teo Y, Simpson S (2014) An observational study of adults with Down syndrome eating independently. Dysphagia 29(1):52–60. https://doi.org/10.1007/S00455-013-9479-4

Article  PubMed  Google Scholar 

Richtsmeier JT, Zumwalt A, Carlson EJ, Epstein CJ, Reeves RH (2002) Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet 107(4):317–324. https://doi.org/10.1002/AJMG.10175

Article  PubMed  Google Scholar 

Glass TJ, Twadell SL, Valmadrid LC, Connor NP (2019) Early impacts of modified food consistency on oromotor outcomes in mouse models of Down syndrome. Physiol Behav 1(199):273–281

Article  Google Scholar 

Hennequin M, Allison PJ, Faulks D, Orliaguet T, Feine J (2005) Chewing indicators between adults with Down syndrome and controls. J Dent Res 84(11):1057–1061. https://doi.org/10.1177/154405910508401117

Article  CAS  PubMed