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Sex-specific molecular drivers of cardiac fibrosis in aging hearts
Sex-specific molecular drivers of cardiac fibrosis in aging hearts
The aging population, defined as individuals 65 years or older, is rapidly increasing, with age as the most signi...
Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan
Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan
Attentional states reflect the changing behavioral relevance of stimuli in one’s environment, having important conse...
Accelerated retinal ageing and multimorbidity in middle-aged and older adults
Accelerated retinal ageing and multimorbidity in middle-aged and older adults
The aim of this study is to investigate the association between retinal age gap and multimorbidity. Retinal age gap was ca...
Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience
Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience
A significant challenge in multi-omic geroscience research is the collection of high quality, fit-for-purpose biospecimens...
Construction and validation of a DNN-based biological age and its influencing factors in the China Kadoorie Biobank
Construction and validation of a DNN-based biological age and its influencing factors in the China Kadoorie Biobank
Biological age is an important measure of aging that reflects an individual’s physical health and is linked to vario...
Aged regulatory T cells fail to control autoimmune lacrimal gland pathogenic CD4 T cells
Aged regulatory T cells fail to control autoimmune lacrimal gland pathogenic CD4 T cells
CD25KO mice are a model of Sjögren disease. CD25KO mice have severe inflammation and infiltrating lymphocytes to the ...
Various diseases and conditions are strongly associated with the next-generation epigenetic aging clock CheekAge
Various diseases and conditions are strongly associated with the next-generation epigenetic aging clock CheekAge
Epigenetic aging clocks represent contemporary aging biomarkers that predict age using methylomic data. These models can b...
Unveiling the geroprotective potential of L.: insights from in vitro studies and a randomized clinical trial on slowing biological aging and improving quality of life
Unveiling the geroprotective potential of L.: insights from in vitro studies and a randomized clinical trial on slowing biological aging and improving quality of life
Aging is driven by fundamental mechanisms like oxidative stress, telomere shortening and changes in DNA methylation, which...
Associations between metabolomic scores and clinical outcomes in hospitalized COVID-19 patients
Associations between metabolomic scores and clinical outcomes in hospitalized COVID-19 patients
The disease course and outcome of COVID-19 greatly varies between individuals. To explore which biological systems may con...
Examining the test–retest reliability of commonly used neuromuscular, morphological, and functional measures in aging adults
Examining the test–retest reliability of commonly used neuromuscular, morphological, and functional measures in aging adults
The present study aimed at determining the test–retest reliability of commonly used measures in a sample of middle-a...
Associations between environmental air pollution, greenspace and apparent biological aging: a cross-sectional study
Associations between environmental air pollution, greenspace and apparent biological aging: a cross-sectional study
Aging is a driving factor of various non-communicable diseases. Air pollution and greenspace also affect human health to v...
Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality
Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality
The link between abnormal sleep duration and stroke outcomes remains contentious. This meta-analysis quantifies how both s...
Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis
Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis
Sleep duration is a crucial factor influencing health outcomes, yet its relationship with mortality remains debated. In th...
Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice
Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice
Transient receptor potential ankyrin 1 (TRPA1) is a sensory channel expressed in vagal afferent nerves that detect noxious...
Automated abdominal aortic calcification scoring from vertebral fracture assessment images and fall-associated hospitalisations: the Manitoba Bone Mineral Density Registry
Automated abdominal aortic calcification scoring from vertebral fracture assessment images and fall-associated hospitalisations: the Manitoba Bone Mineral Density Registry
Abdominal aortic calcification (AAC), a subclinical measure of cardiovascular disease (CVD) that can be assessed on verteb...
Polypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approach
Polypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approach
Polypharmacy is common among older adults and has been linked to adverse outcomes such as dementia, Parkinson’s dise...
Topoisomerase inhibitor amonafide enhances defense responses to promote longevity in
Topoisomerase inhibitor amonafide enhances defense responses to promote longevity in
Aging is a major risk factor for disease, and developing effective pharmaceutical interventions to improve healthspan and ...
Proteomic and phosphoproteomic signatures of aging mouse liver
Proteomic and phosphoproteomic signatures of aging mouse liver
The liver is a metabolic powerhouse, crucial for regulating carbohydrates, fats, and protein metabolism. In this study, we...
Correction to: Role of Toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects
Correction to: Role of Toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects
Correction to: GeroScience (2014) 36:9734The legend for Figure 2 has been corrected a...
The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis Universit...
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator as...
Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax
Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax
Emerging evidence from both clinical and preclinical studies underscores the role of aging in potentiating the detrimental...
Correction to: Functional mobility and physical fitness are improved through a multicomponent training program in institutionalized older adults
Correction to: Functional mobility and physical fitness are improved through a multicomponent training program in institutionalized older adults
Cite this articleLópez‑López, S., Abuín‑Porras, V., Berlanga, L.A. et al. Correction to: Functional mobility and physical ...
The association of leukocyte telomere length with exceptional longevity among older women
The association of leukocyte telomere length with exceptional longevity among older women
The association of leukocyte telomere length (LTL) with survival to late life with intact mobility has not been adequately...
Immune cell composition varies by age, sex and exposure to social adversity in free-ranging Rhesus Macaques
Immune cell composition varies by age, sex and exposure to social adversity in free-ranging Rhesus Macaques
Increasing age is associated with dysregulated immune function and increased inflammation—patterns that are also obs...
The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review
The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review
Functional decline of physiological systems during ageing leads to age-related diseases. Dietary glycine increases healthy...
Comparative analysis of health status and health service utilization patterns among rural and urban elderly populations in Hungary: a study on the challenges of unhealthy aging
Comparative analysis of health status and health service utilization patterns among rural and urban elderly populations in Hungary: a study on the challenges of unhealthy aging
The demographic transition poses a significant challenge for health systems, especially in Central and Eastern European (C...
Age-specific difference in the temporal relationships between updated cardiovascular health construct and arterial stiffness in middle-aged and older adults
Age-specific difference in the temporal relationships between updated cardiovascular health construct and arterial stiffness in middle-aged and older adults
Previous studies have found that the association between modifiable risk factors and arterial stiffness varied with age. W...
Practice makes imperfect: stronger implicit interference with practice in individuals at high risk of developing Alzheimer’s disease
Practice makes imperfect: stronger implicit interference with practice in individuals at high risk of developing Alzheimer’s disease
Early screening to determine patient risk of developing Alzheimer’s will allow better interventions and planning but...
Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies
Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies
Inflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting subclinical, proinflammator...
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