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Brain activation in older adults during odor identification is related to ApoE, t-tau/Aβ1-42, and hippocampal volume
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Aging of Gray Matter Microstructure: A Brain-wide Characterization of, Age Group Differences using NODDI
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Advancing age and sex modulate antidyskinetic efficacy of striatal CaV1.3 gene therapy in a rat model of Parkinson’s disease
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Inter-network functional connectivity increases by beta-amyloid and may facilitate the early stage of tau accumulation
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Stability of locus coeruleus cell counts despite volume loss in cognitively impaired aged rhesus macaques
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Differences in cholinergic terminal density in adults with Down syndrome compared to neurotypical controls measured by [18F]-fluoroethoxybenzovesamicol positron emission tomography imaging
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Exploring the domain specificity and the neural correlates of memory unawareness in Alzheimer's disease
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Circulating non-esterified fatty acids, risk of dementia and cognitive decline: The cardiovascular health study and multi-ethnic study of atherosclerosis
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Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions
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Network segregation during episodic memory shows age-invariant relations with memory performance from 7 to 82 years
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Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging
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Exploring morphological and microstructural signatures across the Alzheimer's spectrum and risk factors
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Normative aging results in degradation of gene networks in a zebra finch basal ganglia nucleus dedicated to vocal behavior
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Does functional system segregation mediate the effects of lifestyle on cognition in older adults?
Does functional system segregation mediate the effects of lifestyle on cognition in older adults?
Healthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work a...
Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis
Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis
Among older people, age-related hearing loss is the most common sensory disturbance and is characterized by progressive lo...
Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study
Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study
Chronic low-grade inflammation (or “inflammaging”) is a common hallmark of ageing and is associated with diabetes, obesity...
Prevalence of cerebral microbleeds in Alzheimer’s disease, dementia with Lewy bodies and Parkinson’s disease dementia: a systematic review and meta-analysis
Prevalence of cerebral microbleeds in Alzheimer’s disease, dementia with Lewy bodies and Parkinson’s disease dementia: a systematic review and meta-analysis
Cerebral microbleeds (CMB) are small, round, focal haemorrhages visible on T2*-weighted gradient-recalled echo (GRE) or su...
Rare variant analysis of UQCRC1 in Chinese patients with early-onset Parkinson’s disease
Rare variant analysis of UQCRC1 in Chinese patients with early-onset Parkinson’s disease
Although the exact cause of Parkinson’s disease (PD) remains unknown, genetic and environmental factors have been found to...
Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra
Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra
The selective loss of substantia nigra (SN) dopaminergic (DA) neurons in neurodegenerative disorders including Parkinson’s...
Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis
Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis
Current genome-wide association studies of frontotemporal dementia (FTD) are underpowered due to limited samples. Further,...
Role and molecular regulatory mechanisms of Hippo signaling pathway in Caenorhabditis elegans and mammalian cell models of Alzheimer’s disease
Role and molecular regulatory mechanisms of Hippo signaling pathway in Caenorhabditis elegans and mammalian cell models of Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive decline of cognitive function from th...
Identifying risk loci for FTD and shared genetic component with ALS: a large-scale multi-trait association analysis
Identifying risk loci for FTD and shared genetic component with ALS: a large-scale multi-trait association analysis
Current genome-wide association studies of frontotemporal dementia (FTD) are underpowered due to limited samples. Further,...
Identifying potential genetic epistasis implicated in Alzheimer's disease via detection of SNP-SNP interaction on quantitative trait CSF Aβ42
Identifying potential genetic epistasis implicated in Alzheimer's disease via detection of SNP-SNP interaction on quantitative trait CSF Aβ42
Although genome-wide association studies (GWAS) have identified multiple Alzheimer's disease (AD)-associated loci by selec...
FRONTOPARIETAL FUNCTION AND UNDERLYING STRUCTURE REFLECT CAPACITY FOR MOTOR SKILL ACQUISITION DURING HEALTHY AGING
FRONTOPARIETAL FUNCTION AND UNDERLYING STRUCTURE REFLECT CAPACITY FOR MOTOR SKILL ACQUISITION DURING HEALTHY AGING
SK: data curation, formal analysis, visualization, writing – original draft, writing – review & editing. CR: investiga...
Dopamine Transporter Positron Emission Tomography in Patients with Alzheimer’s Disease with Lewy Body Disease Features
Dopamine Transporter Positron Emission Tomography in Patients with Alzheimer’s Disease with Lewy Body Disease Features
Alzheimer’s disease (AD) (McKhann et al., 2011), the most common neurodegenerative cause of dementia, is characterized by ...
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer’s disease pathophysiology: a longitudinal study
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer’s disease pathophysiology: a longitudinal study
Available online 8 November 2023Author links open overlay panel, , , , , , , , , , , Highlights•In both CN and MCI patient...
Changes in an in-vivo classifier of ARTerioloSclerosis (ARTS) with simultaneous change in cognition for older African Americans
Changes in an in-vivo classifier of ARTerioloSclerosis (ARTS) with simultaneous change in cognition for older African Americans
African American decedents, at autopsy, often have mixed brain neuropathologies that include cerebrovascular disease (Barn...
A Genetic and Transcriptomic Assessment of the KTN1 Gene in Parkinson’s Disease Risk
A Genetic and Transcriptomic Assessment of the KTN1 Gene in Parkinson’s Disease Risk
Multiple studies have shown an association between KTN1 variants and changes in expression levels and brain structure incl...
Midlife Physical Activity Engagement is Associated With Later-life Brain Health
Midlife Physical Activity Engagement is Associated With Later-life Brain Health
The number of older individuals with Alzheimer’s disease (AD) reached 6.5 million in 2022 in the United States (Alzheimer’...
CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system
CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system
Evidence indicates that dysfunction of older Schwann cells and macrophages contributes to poor regeneration of more mature...
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