Usuba FS, et al. Sjogren’s syndrome: an underdiagnosed condition in mixed connective tissue disease. Clinics (Sao Paulo). 2014;69(3):158–62.

Article  PubMed  Google Scholar 

Haugen AJ, et al. Estimation of the prevalence of primary Sjogren’s syndrome in two age-different community-based populations using two sets of classification criteria: the Hordaland Health Study. Scand J Rheumatol. 2008;37(1):30–4.

Article  CAS  PubMed  Google Scholar 

Gondran G, et al. Primary Sjogren’s syndrome in men. Scand J Rheumatol. 2008;37(4):300–5.

Article  CAS  PubMed  Google Scholar 

Ramirez Sepulveda JI, et al. Difference in clinical presentation between women and men in incident primary Sjogren’s syndrome. Biol Sex Differ. 2017;8:16.

Article  PubMed  PubMed Central  Google Scholar 

Ramirez Sepulveda JI, et al. Long-term follow-up in primary Sjogren’s syndrome reveals differences in clinical presentation between female and male patients. Biol Sex Differ. 2017;8(1):25.

Article  PubMed  PubMed Central  Google Scholar 

Nezos A, Mavragani CP. Contribution of genetic factors to Sjogren’s syndrome and Sjogren’s syndrome related lymphomagenesis. J Immunol Res. 2015;2015:754825.

Article  PubMed  PubMed Central  Google Scholar 

Christodoulou MI, et al. Foxp3+ T-regulatory cells in Sjogren’s syndrome: correlation with the grade of the autoimmune lesion and certain adverse prognostic factors. Am J Pathol. 2008;173(5):1389–96.

Article  PubMed  PubMed Central  Google Scholar 

Garcia-Carrasco M, et al. Primary Sjogren syndrome: clinical and immunologic disease patterns in a cohort of 400 patients. Medicine (Baltimore). 2002;81(4):270–80.

Article  PubMed  Google Scholar 

Pflugfelder SC, de Paiva CS. The pathophysiology of dry eye disease: what we know and future directions for research. Ophthalmology. 2017;124(11S):S4–13.

Article  PubMed  Google Scholar 

Sharma R, et al. The role of Fas in the immune system biology of IL-2R alpha knockout mice: interplay among regulatory T cells, inflammation, hemopoiesis, and apoptosis. J Immunol. 2005;175(3):1965–73.

Article  CAS  PubMed  Google Scholar 

Sharma R, et al. A regulatory T cell-dependent novel function of CD25 (IL-2Ralpha) controlling memory CD8(+) T cell homeostasis. J Immunol. 2007;178(3):1251–5.

Article  CAS  PubMed  Google Scholar 

Rahimy E, et al. Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol. 2010;177(2):744–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vang KB, et al. IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J Immunol. 2008;181(5):3285–90.

Article  CAS  PubMed  Google Scholar 

Lio CW, Hsieh CS. A two-step process for thymic regulatory T cell development. Immunity. 2008;28(1):100–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan MY, et al. Differential roles of IL-2 signaling in developing versus mature Tregs. Cell Rep. 2018;25(5):1204-1213.e4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Willerford DM, et al. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995;3(4):521–30.

Article  CAS  PubMed  Google Scholar 

Malek TR. The main function of IL-2 is to promote the development of T regulatory cells. J Leukoc Biol. 2003;74(6):961–5.

Article  CAS  PubMed  Google Scholar 

D’Cruz LM, Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol. 2005;6(11):1152–9.

Article  CAS  PubMed  Google Scholar 

Fontenot JD, et al. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol. 2005;6(11):1142–51.

Article  CAS  PubMed  Google Scholar 

Toomer KH, et al. Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells. Nat Commun. 2019;10(1):1037.

Article  PubMed  PubMed Central  Google Scholar 

De Paiva CS, et al. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren’s syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010;49(2):246–58.

Article  PubMed  Google Scholar 

Sadlack B, et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 1993;75(2):253–61.

Article  CAS  PubMed  Google Scholar 

Gottenberg JE, et al. CD4 CD25high regulatory T cells are not impaired in patients with primary Sjogren’s syndrome. J Autoimmun. 2005;24(3):235–42.

Article  CAS  PubMed  Google Scholar 

Sarigul M, et al. The numbers of Foxp3 + Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren’s syndrome. Lupus. 2010;19(2):138–45.

Article  CAS  PubMed  Google Scholar 

Alunno A, et al. Expansion of CD4+CD25-GITR+ regulatory T-cell subset in the peripheral blood of patients with primary Sjogren’s syndrome: correlation with disease activity. Reumatismo. 2012;64(5):293–8.

Article  CAS  PubMed  Google Scholar 

Ivanchenko M, et al. FoxP3(+) CXCR5(+) CD4(+) T cell frequencies are increased in peripheral blood of patients with primary Sjogren’s syndrome. Clin Exp Immunol. 2019;195(3):305–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schaefer L, et al. Gut microbiota from Sjogren syndrome patients causes decreased T regulatory cells in the lymphoid organs and desiccation-induced corneal barrier disruption in mice. Front Med (Lausanne). 2022;9: 852918.

Article  PubMed  Google Scholar 

Keindl M, et al. Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjogren’s syndrome. Arthritis Res Ther. 2022;24(1):101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elyahu Y et al. Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes. Sci Adv. 2019;5(8):p. eaaw8330.

Sharma S, Dominguez AL, Lustgarten J. High accumulation of T regulatory cells prevents the activation of immune responses in aged animals. J Immunol. 2006;177(12):8348–55.

Article  CAS  PubMed  Google Scholar 

Lages CS, et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol. 2008;181(3):1835–48.

Article  CAS  PubMed  Google Scholar 

Trujillo-Vargas CM et al. Immune phenotype of the CD4(+) T cells in the aged lymphoid organs and lacrimal glands. Geroscience. 2022;44(4):2105-2128.

Coursey TG, et al. Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017;10(3):743–56.

Article  CAS  PubMed  Google Scholar 

Guo Z, et al. DCAF1 regulates Treg senescence via the ROS axis during immunological aging. J Clin Inv