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Aging reduces liver resiliency by dysregulating Hedgehog signaling
Aging reduces liver resiliency by dysregulating Hedgehog signaling
Abstract Older age is a major risk factor for damage to many tissues, including liver. Aging undermines resiliency and imp...
Emerging rejuvenation strategies—Reducing the biological age
Emerging rejuvenation strategies—Reducing the biological age
Abstract Several interventions have recently emerged that were proposed to reverse rather than just attenuate aging, but t...
Corrigendum to: Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice
Corrigendum to: Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice
Archana Unnikrishnan, Stephanie Matyi, Karla Garret, Michelle Ranjo-Bishop, David B. Allison, Keisuke Ejima, Xiwei Chen, S...
Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics
Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics
Abstract Aging and senescence impact CD4 T helper cell (Th) subset differentiation during influenza infection. In the lung...
Chemically induced senescence in human stem cell‐derived neurons promotes phenotypic presentation of neurodegeneration
Chemically induced senescence in human stem cell‐derived neurons promotes phenotypic presentation of neurodegeneration
Abstract Modeling age-related neurodegenerative disorders with human stem cells are difficult due to the embryonic nature ...
Increased MFG‐E8 at neuromuscular junctions is an exacerbating factor for sarcopenia‐associated denervation
Increased MFG‐E8 at neuromuscular junctions is an exacerbating factor for sarcopenia‐associated denervation
Abstract Sarcopenia is an important health problem associated with adverse outcomes. Although the etiology of sarcopenia r...
Physiological clearance of Aβ by spleen and splenectomy aggravates Alzheimer‐type pathogenesis
Physiological clearance of Aβ by spleen and splenectomy aggravates Alzheimer‐type pathogenesis
Abstract Background A previous study demonstrated that nearly 40%–60% of brain Aβ flows out into the peripher...
New lessons on TDP‐43 from old N. furzeri killifish
New lessons on TDP‐43 from old N. furzeri killifish
Abstract Frontotemporal dementia and amyotrophic lateral sclerosis are fatal and incurable neurodegenerative diseases link...
Late‐life exercise mitigates skeletal muscle epigenetic aging
Late‐life exercise mitigates skeletal muscle epigenetic aging
Abstract There are functional benefits to exercise in muscle, even when performed late in life, but the contributions of e...
The age factor in optic nerve regeneration: Intrinsic and extrinsic barriers hinder successful recovery in the short‐living killifish
The age factor in optic nerve regeneration: Intrinsic and extrinsic barriers hinder successful recovery in the short‐living killifish
Abstract As the mammalian central nervous system matures, its regenerative ability decreases, leading to incomplete or non...
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy
Abstract The “rejuvenating” effect of growth differentiation factor 11 (GDF11) is called into question recen...
Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease
Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease
Abstract Experimental and clinical therapies in the field of Alzheimer's disease (AD) have focused on elimination of extra...
A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR‐24‐3p/CDK4/pRb axis
A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR‐24‐3p/CDK4/pRb axis
Abstract Circular RNAs (circRNAs) have been established to be involved in numerous processes in the human genome, but thei...
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
Abstract Systemic deletion of senescent cells leads to robust improvements in cognitive, cardiovascular, and whole-body me...
Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus
Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus
Abstract The increase in senescent cells in tissues, including the brain, is a general feature of normal aging and age-rel...
Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene‐diet interaction that ensures optimal life span
Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene‐diet interaction that ensures optimal life span
Abstract Diet regulates complex life-history traits such as longevity. For optimal lifespan, organisms employ intricate ad...
Inhibition of DNA methyltransferase aberrations reinstates antioxidant aging suppressors and ameliorates renal aging
Inhibition of DNA methyltransferase aberrations reinstates antioxidant aging suppressors and ameliorates renal aging
Abstract DNA methylation alterations play mechanistic roles in aging; however, the epigenetic regulators/mediators causall...
Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes
Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes
Abstract Metformin, the most commonly prescribed anti-diabetes medication, has multiple reported health benefits, includin...
Phenotype correlations reveal the relationships of physiological systems underlying human ageing
Phenotype correlations reveal the relationships of physiological systems underlying human ageing
Abstract Ageing is characterized by degeneration and loss of function across multiple physiological systems. To study the ...
Nogo receptor impairs the clearance of fibril amyloid‐β by microglia and accelerates Alzheimer’s‐like disease progression
Nogo receptor impairs the clearance of fibril amyloid‐β by microglia and accelerates Alzheimer’s‐like disease progression
Abstract Alzheimer's disease (AD) is characterized by the progressive accumulation of β-amyloid (Aβ)-containin...
Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan
Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan
Abstract Studies in multiple species indicate that reducing growth hormone (GH) action enhances healthy lifespan. In fact,...
Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice
Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice
Abstract The liver plays a pivotal role in mammalian aging. However, the mechanisms underlying liver aging remain unclear....
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease
Abstract The cell-to-cell transfer of α-synuclein (α-Syn) greatly contributes to Parkinson's disease (PD) path...
Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging
Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging
Abstract Somatopause refers to the gradual declines in growth hormone (GH) and insulin-like growth factor-1 throughout agi...
α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease
α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease
Abstract SNCA protein product, α-synuclein, is widely renowned for its role in synaptogenesis and implication in bot...
Mitochondrial aconitase 1 regulates age‐related memory impairment via autophagy/mitophagy‐mediated neural plasticity in middle‐aged flies
Mitochondrial aconitase 1 regulates age‐related memory impairment via autophagy/mitophagy‐mediated neural plasticity in middle‐aged flies
Abstract Age-related memory impairment (AMI) occurs in many species, including humans. The underlying mechanisms are not f...
Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease
Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease
Abstract Clinical studies have shown that female brains are more predisposed to neurodegenerative diseases such as Alzheim...
Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation
Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation
Abstract Adiponectin (APN) deficiency has also been associated with Alzheimer-like pathologies. Recent studies have illumi...
miR‐125a‐5p increases cellular DNA damage of aging males and perturbs stage‐specific embryo development via Rbm38‐p53 signaling
miR‐125a‐5p increases cellular DNA damage of aging males and perturbs stage‐specific embryo development via Rbm38‐p53 signaling
Abstract An increasing number of men are fathering children at an older age than in the past. While advanced maternal age ...
Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells
Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells
Abstract Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial in...
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