Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis

Drake CL, Roehrs T, Roth T. Insomnia causes, consequences, and therapeutics: an overview. Depress Anxiety. 2003;18:163–76. https://doi.org/10.1002/da.10151.

Article  PubMed  Google Scholar 

Owens JA, Weiss MR. Insufficient sleep in adolescents: causes and consequences. Minerva Pediatr. 2017;69:326–36. https://doi.org/10.23736/S0026-4946.17.04914-3.

Article  PubMed  Google Scholar 

Alreshidi SM, Rayani AM. The correlation between night shift work schedules, sleep quality, and depression symptoms. Neuropsychiatr Dis Treat. 2023;19:1565–71. https://doi.org/10.2147/NDT.S421092.

Article  PubMed  PubMed Central  Google Scholar 

Roman P, Perez-Cayuela I, Gil-Hernandez E, Rodriguez-Arrastia M, Aparicio-Mota A, Ropero-Padilla C, Rueda-Ruzafa L. Influence of shift work on the health of nursing professionals. J Pers Med. 2023;13. https://doi.org/10.3390/jpm13040627.

Lin S, Gao M, Zhang J, Wu Y, Yu T, Peng Y, Jia Y, Zou H, Lu L, Li D, Ma Y. Sleep onset time as a mediator in the association between screen exposure and aging: a cross-sectional study. Geroscience. 2024. https://doi.org/10.1007/s11357-024-01321-x.

Article  PubMed  PubMed Central  Google Scholar 

Csipo T, Lipecz A, Owens C, Mukli P, Perry JW, Tarantini S, Balasubramanian P, Nyul-Toth A, Yabluchanska V, Sorond FA, Kellawan JM, Purebl G, Sonntag WE, Csiszar A, Ungvari Z, Yabluchanskiy A. Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses. Sci Rep. 2021;11:20994. https://doi.org/10.1038/s41598-021-00188-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mukli P, Csipo T, Lipecz A, Stylianou O, Racz FS, Owens CD, Perry JW, Tarantini S, Sorond FA, Kellawan JM, Purebl G, Yang Y, Sonntag WE, Csiszar A, Ungvari ZI, Yabluchanskiy A. Sleep deprivation alters task-related changes in functional connectivity of the frontal cortex: a near-infrared spectroscopy study. Brain Behav. 2021;11: e02135. https://doi.org/10.1002/brb3.2135.

Article  PubMed  PubMed Central  Google Scholar 

Chen WH, Chen J, Lin X, Li P, Shi L, Liu JJ, Sun HQ, Lu L, Shi J. Dissociable effects of sleep deprivation on functional connectivity in the dorsal and ventral default mode networks. Sleep Med. 2018;50:137–44. https://doi.org/10.1016/j.sleep.2018.05.040.

Article  PubMed  Google Scholar 

Akkaoui MA, Palagini L, Geoffroy PA. Sleep immune cross talk and insomnia. Adv Exp Med Biol. 2023;1411:263–73. https://doi.org/10.1007/978-981-19-7376-5_12.

Article  CAS  PubMed  Google Scholar 

Belloir J, Makarem N, Shechter A. Sleep and circadian disturbance in cardiovascular risk. Curr Cardiol Rep. 2022;24:2097–107. https://doi.org/10.1007/s11886-022-01816-z.

Article  PubMed  PubMed Central  Google Scholar 

Antza C, Kostopoulos G, Mostafa S, Nirantharakumar K, Tahrani A. The links between sleep duration, obesity and type 2 diabetes mellitus. J Endocrinol. 2021;252:125–41. https://doi.org/10.1530/JOE-21-0155.

Article  PubMed  PubMed Central  Google Scholar 

Mukherjee U, Sehar U, Brownell M, Reddy PH. Mechanisms, consequences and role of interventions for sleep deprivation: focus on mild cognitive impairment and Alzheimer’s disease in elderly. Ageing Res Rev. 2024;100: 102457. https://doi.org/10.1016/j.arr.2024.102457.

Article  PubMed  Google Scholar 

Sadeghmousavi S, Eskian M, Rahmani F, Rezaei N. The effect of insomnia on development of Alzheimer’s disease. J Neuroinflammation. 2020;17:289. https://doi.org/10.1186/s12974-020-01960-9.

Article  PubMed  PubMed Central  Google Scholar 

Chung WS, Lin CL. Sleep disorders associated with risk of prostate cancer: a population-based cohort study. BMC Cancer. 2019;19:146. https://doi.org/10.1186/s12885-019-5361-6.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Tan F, Wei L, Li X, Lyu Z, Feng X, Wen Y, Guo L, He J, Dai M, Li N. Sleep duration and the risk of cancer: a systematic review and meta-analysis including dose-response relationship. BMC Cancer. 2018;18:1149. https://doi.org/10.1186/s12885-018-5025-y.

Article  PubMed  PubMed Central  Google Scholar 

Blask DE. Melatonin, sleep disturbance and cancer risk. Sleep Med Rev. 2009;13:257–64. https://doi.org/10.1016/j.smrv.2008.07.007.

Article  PubMed  Google Scholar 

Irwin MR. Sleep and inflammation: partners in sickness and in health. Nat Rev Immunol. 2019;19:702–15. https://doi.org/10.1038/s41577-019-0190-z.

Article  CAS  PubMed  Google Scholar 

Villafuerte G, Miguel-Puga A, Rodriguez EM, Machado S, Manjarrez E, Arias-Carrion O. Sleep deprivation and oxidative stress in animal models: a systematic review. Oxid Med Cell Longev. 2015;2015: 234952. https://doi.org/10.1155/2015/234952.

Article  PubMed  PubMed Central  Google Scholar 

Wynchank D, Bijlenga D, Penninx BW, Lamers F, Beekman AT, Kooij JJS, Verhoeven JE. Delayed sleep-onset and biological age: late sleep-onset is associated with shorter telomere length. Sleep. 2019;42. https://doi.org/10.1093/sleep/zsz139.

Kusters CDJ, Klopack ET, Crimmins EM, Seeman TE, Cole S, Carroll JE. Short sleep and insomnia are associated with accelerated epigenetic age. Psychosom Med. 2024;86:453–62. https://doi.org/10.1097/PSY.0000000000001243.

Article  PubMed  Google Scholar 

Noroozi R, Rudnicka J, Pisarek A, Wysocka B, Masny A, Boron M, Migacz-Gruszka K, Pruszkowska-Przybylska P, Kobus M, Lisman D, Zielinska G, Iljin A, Wiktorska JA, Michalczyk M, Kaczka P, Krzysztofik M, Sitek A, Ossowski A, Spolnicka M, Branicki W, Pospiech E. Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging. Geroscience. 2024;46:2583–604. https://doi.org/10.1007/s11357-023-01029-4.

Article  CAS  PubMed  Google Scholar 

Cappuccio FP, D’Elia L, Strazzullo P, Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep. 2010;33:585–92. https://doi.org/10.1093/sleep/33.5.585.

Article  PubMed  PubMed Central  Google Scholar 

Cappuccio FP, Miller MA. Sleep and mortality: cause, consequence, or symptom? Sleep Med. 2013;14:587–8. https://doi.org/10.1016/j.sleep.2013.04.001.

Article  PubMed  Google Scholar 

García-Perdomo HA, Zapata-Copete J, Rojas-Cerón CA. Sleep duration and risk of all-cause mortality: a systematic review and meta-analysis. Epidemiol Psychiatr Sci. 2019;28:578–88. https://doi.org/10.1017/s2045796018000379.

Article  PubMed  Google Scholar 

Pienaar PR, Kolbe-Alexander TL, van Mechelen W, Boot CRL, Roden LC, Lambert EV, Rae DE. Associations between self-reported sleep duration and mortality in employed individuals: systematic review and meta-analysis. Am J Health Promot. 2021;35:853–65. https://doi.org/10.1177/0890117121992288.

Article  PubMed  Google Scholar 

Yin J, Jin X, Shan Z, Li S, Huang H, Li P, Peng X, Peng Z, Yu K, Bao W, Yang W, Chen X, Liu L. Relationship of sleep duration with all-cause mortality and cardiovascular events: a systematic review and dose-response meta-analysis of prospective cohort studies. J Am Heart Assoc. 2017;6. https://doi.org/10.1161/jaha.117.005947.

Kwok CS, Kontopantelis E, Kuligowski G, Gray M, Muhyaldeen A, Gale CP, Peat GM, Cleator J, Chew-Graham C, Loke YK, Mamas MA. Self-reported sleep duration and quality and cardiovascular disease and mortality: a dose-response meta-analysis. J Am Heart Assoc. 2018;7: e008552. https://doi.org/10.1161/jaha.118.008552.

Article  PubMed  PubMed Central  Google Scholar 

Stone CR, Haig TR, Fiest KM, McNeil J, Brenner DR, Friedenreich CM. The association between sleep duration and cancer-specific mortality: a systematic review and meta-analysis. Cancer Causes Control. 2019;30:501–25. https://doi.org/10.1007/s10552-019-01156-4.

Article  PubMed  Google Scholar 

Fekete JT, Gyorffy B. MetaAnalysisOnline.com: an online tool for the rapid meta-analysis of clinical and epidemiological studies. J Med Internet Res. 2025. https://doi.org/10.2196/64016.

Aurora RN, Kim JS, Crainiceanu C, O’Hearn D, Punjabi NM. Habitual sleep duration and all-cause mortality in a general community sample. Sleep. 2016;39:1903–9. https://doi.org/10.5665/sleep.6212.

Article  PubMed  PubMed Central  Google Scholar 

Rumble R, Morgan K. Hypnotics, sleep, and mortality in elderly people. J Am Geriatr Soc. 1992;40:787–91. https://doi.org/10.1111/j.1532-5415.1992.tb01850.x.

Article  CAS  PubMed  Google Scholar 

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