SCI Abstract

search
+
Widespread in situ follicular neoplasia in patients who subsequently developed follicular lymphoma
Widespread in situ follicular neoplasia in patients who subsequently developed follicular lymphoma
Abstract In situ follicular neoplasia (ISFN) is usually an occasional incidental finding in lymph nodes by BCL2 immunohist...
Neutrophil extracellular traps drive epithelial‐mesenchymal transition of human colon cancer
Neutrophil extracellular traps drive epithelial‐mesenchymal transition of human colon cancer
Abstract Neutrophil extracellular traps (NETs) are extracellular structures, composed of nuclear DNA and various proteins ...
MyD88 in myofibroblasts regulates aerobic glycolysis‐driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation
MyD88 in myofibroblasts regulates aerobic glycolysis‐driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation
Abstract Hepatic stellate cells (HSCs) and cancer-associated fibroblasts (CAFs) play critical roles in liver fibrosis and ...
Jeremy Jass Prize for Research Excellence in Pathology 2020
Jeremy Jass Prize for Research Excellence in Pathology 2020
See related doi: 10.1002/path.5373
Myeloma cells regulate miRNA transfer from fibroblast‐derived exosomes by expression of lncRNAs
Myeloma cells regulate miRNA transfer from fibroblast‐derived exosomes by expression of lncRNAs
Abstract Multiple myeloma (MM) progression and drug resistance depend on the crosstalk between MM cells and bone marrow (B...
EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma
EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma
Abstract Alveolar Rhabdomyosarcoma (ARMS) is an aggressive paediatric cancer with poor prognosis. Cancer stem cells (CSC) ...
Validated biomarker assays confirm ARID1A loss is confounded with MMR deficiency, CD8 TIL infiltration, and provides no independent prognostic value in endometriosis‐associated ovarian carcinomas
Validated biomarker assays confirm ARID1A loss is confounded with MMR deficiency, CD8 TIL infiltration, and provides no independent prognostic value in endometriosis‐associated ovarian carcinomas
Abstract ARID1A (BAF250a) is a component of the SWI/SNF chromatin modifying complex, plays an important tumour suppressor ...
NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis
NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis
Abstract Up to 50% of amyotrophic lateral sclerosis patients present with cognitive deficits in addition to motor dysfunct...
Activin B, a new player in kidney fibrosis?†
Activin B, a new player in kidney fibrosis?†
Abstract Interest has been growing in the role of activin A in both acute and chronic kidney disease. The role of other ac...
B7H3 expression and significance in idiopathic pulmonary fibrosis
B7H3 expression and significance in idiopathic pulmonary fibrosis
Abstract The clinical significance of B7H3 (CD276) and its cleavage product soluble B7H3 (sB7H3) in idiopathic pulmonary f...
Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption†
Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption†
Abstract Investigations of major mevalonate pathway enzymes have demonstrated the importance of local isoprenoid synthesis...
Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in CIC‐knockout and IDH1 mutant cells
Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in CIC‐knockout and IDH1 mutant cells
Abstract Capicua (CIC)'s transcriptional repressor function is implicated in neurodevelopment and in oligodendroglioma (OD...
SWI/SNF‐deficient undifferentiated malignancies: where to draw the line†
SWI/SNF‐deficient undifferentiated malignancies: where to draw the line†
Abstract Alterations in chromatin remodelling genes are increasingly recognised as drivers of undifferentiated malignancie...
Deep Learning identifies inflamed fat as a risk factor for lymph node metastasis in early colorectal cancer
Deep Learning identifies inflamed fat as a risk factor for lymph node metastasis in early colorectal cancer
Abstract The spread of early-stage (T1 and T2) adenocarcinomas to loco-regional lymph nodes is a key event in disease prog...
Metabolic tumor constitution is superior to tumor regression grading for evaluating response to neoadjuvant therapy of esophageal adenocarcinoma patients
Metabolic tumor constitution is superior to tumor regression grading for evaluating response to neoadjuvant therapy of esophageal adenocarcinoma patients
Abstract The response to neoadjuvant therapy can vary widely between individual patients. Histopathological tumor regressi...
Mouse‐INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy
Mouse‐INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy
Abstract Due to widespread adoption of screening mammography, there has been a significant increase in new diagnoses of du...
FOXL2C134W: much ado about something!†
FOXL2C134W: much ado about something!†
Abstract Recent studies have suggested that the unique FOXL2C134W mutation, which is pathognomonic for adult granulosa cel...
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer
Abstract Prostate cancer (PCa) remains a leading cause of cancer-related deaths in American men and treatment options for ...
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation
Abstract Ameloblastoma is an odontogenic neoplasm characterized by slow intraosseous growth with progressive jaw resorptio...
Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involvement
Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involvement
Abstract Recessive variants in WASHC4 are linked to intellectual disability complicated by poor language skills, short sta...
Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease
Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease
Abstract As acute pancreatitis progresses to the severe form a life-threatening systemic inflammation is triggered. Althou...
Mutation and methylation profiles of ectopic and eutopic endometrial tissues
Mutation and methylation profiles of ectopic and eutopic endometrial tissues
Abstract Adenomyosis and peritoneal endometriosis are common gynecologic lesions; they are characterized by aberrant locat...
Ethanol‐induced formation of colorectal tumours and precursors in a mouse model of Lynch Syndrome
Ethanol‐induced formation of colorectal tumours and precursors in a mouse model of Lynch Syndrome
Abstract Lynch Syndrome (LS) confers inherited cancer predisposition due to germline mutations in a DNA mismatch repair (M...
The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images
The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images
Abstract The color variation of hematoxylin and eosin (H&E)-stained tissues has presented a challenge for applications of ...
Tubule‐derived INHBB promotes interstitial fibroblast activation and renal fibrosis
Tubule‐derived INHBB promotes interstitial fibroblast activation and renal fibrosis
Abstract Upstream stimuli for myofibroblast activation are of considerable interest for understanding the mechanisms under...
Artificial intelligence strategy integrating morphologic and architectural biomarkers provides robust diagnostic accuracy for disease progression in Chronic Lymphocytic Leukemia
Artificial intelligence strategy integrating morphologic and architectural biomarkers provides robust diagnostic accuracy for disease progression in Chronic Lymphocytic Leukemia
Abstract Artificial intelligence-based tools designed to assist in the diagnosis of lymphoid neoplasms remain limited. The...
Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer
Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer
Abstract Immune cells of the tumor microenvironment are central but erratic targets for immunotherapy. The aim of this stu...
Cardiac–specific deletion of FDPS induces cardiac remodeling and dysfunction by enhancing the activity of small GTP–binding proteins
Cardiac–specific deletion of FDPS induces cardiac remodeling and dysfunction by enhancing the activity of small GTP–binding proteins
Abstract The mevalonate pathway is essential for cholesterol biosynthesis. Previous studies have suggested that the key en...
Generation of ductal organoids from normal mammary luminal cells reveals invasive potential
Generation of ductal organoids from normal mammary luminal cells reveals invasive potential
Abstract Here, we present an experimental model for human luminal progenitor cells that enables single, primary cells isol...
Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11‐deficient mice
Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11‐deficient mice
Abstract ABCB11 encodes bile salt export pump (BSEP), a key regulator in maintaining bile acid (BA) homeostasis. Although ...
Load More
format_indent_increase