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Biography—Mathieu Boissan, Pharm.D., Ph.D
Biography—Mathieu Boissan, Pharm.D., Ph.D
Mathieu Boissan, Pharm.D., Ph.D.Mathieu Boissan, Pharm.D., Ph.D. is a cellular biolo...
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
Colorectal cancer is the third most common and the second deadliest cancer worldwide. To date, colorectal cancer becomes o...
Glucocorticoid receptor: a harmonizer of cellular plasticity in breast cancer—directs the road towards therapy resistance, metastatic progression and recurrence
Glucocorticoid receptor: a harmonizer of cellular plasticity in breast cancer—directs the road towards therapy resistance, metastatic progression and recurrence
Recent therapeutic advances have significantly uplifted the quality of life in breast cancer patients, yet several impedim...
Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals
Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals
Plasticity of phenotypic traits refers to an organism’s ability to change in response to environmental stimuli. As a...
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
We describe here the molecular basis of the complex formation of PRUNE1 with the tumor metastasis suppressors NME1 and NME...
UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect
UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect
Pancreatic cancer has an exaggerated dependence on mitochondrial metabolism, but methods to specifically target the mitoch...
Deciphering cellular plasticity in pancreatic cancer for effective treatments
Deciphering cellular plasticity in pancreatic cancer for effective treatments
Cellular plasticity and therapy resistance are critical features of pancreatic cancer, a highly aggressive and fatal disea...
The emerging roles of histone demethylases in cancers
The emerging roles of histone demethylases in cancers
Modulation of histone methylation status is regarded as an important mechanism of epigenetic regulation and has substantia...
Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs cellular shape and function change...
Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy
Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy
T cells, a key component of cancer immunotherapy, undergo a variety of histone modifications and DNA methylation changes s...
The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression
The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression
Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the contribution of genetic and ep...
Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance
Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance
Circular RNAs (circRNAs) are a member of non-coding RNAs with no ability in encoding proteins and their aberrant dysregula...
Clusterin: a marker and mediator of chemoresistance in colorectal cancer
Clusterin: a marker and mediator of chemoresistance in colorectal cancer
Intra-tumoural heterogeneity and cancer cell plasticity in colorectal cancer (CRC) have been key challenges to effective t...
Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plast...
Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation
Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation
Prostate cancer (PCa) is a malignant disorder of prostate gland being asymptomatic in early stages and high metastatic pot...
Comprehensive assessment of TECENTRIQ® and OPDIVO®: analyzing immunotherapy indications withdrawn in triple-negative breast cancer and hepatocellular carcinoma
Comprehensive assessment of TECENTRIQ® and OPDIVO®: analyzing immunotherapy indications withdrawn in triple-negative breast cancer and hepatocellular carcinoma
Atezolizumab (TECENTRIQ®) and nivolumab (OPDIVO®) are both immunotherapeutic indications targeting programmed ce...
HOXA9 transcription factor is a double-edged sword: from development to cancer progression
HOXA9 transcription factor is a double-edged sword: from development to cancer progression
The HOXA9 transcription factor serves as a molecular orchestrator in cancer stemness, epithelial-mesenchymal transition (E...
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is associated with enhanced lipogenesis...
Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance
Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance
This comprehensive review explores vimentin as a pivotal therapeutic target in cancer treatment, with a primary focus on m...
Metastasis suppressor genes and their role in the tumor microenvironment
Metastasis suppressor genes and their role in the tumor microenvironment
The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells a...
Clonal tracking in cancer and metastasis
Clonal tracking in cancer and metastasis
The eradication of many cancers has proven challenging due to the presence of functionally and genetically heterogeneous c...
Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer
Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer
Air pollutants are increasingly emitted into the atmosphere because of the high dependency of humans on fossil-derived fue...
Prospects of earthworm coelomic fluid as a potential therapeutic agent to treat cancer
Prospects of earthworm coelomic fluid as a potential therapeutic agent to treat cancer
Cancer is a major public health concern because it is one of the main causes of morbidity and mortality worldwide. As a re...
From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies
From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies
MYB transcription factors are encoded by a large family of highly conserved genes from plants to vertebrates. There are th...
Tumor ablation induced anti-tumor immunity: destruction of the tumor in situ with the aim to evoke a robust anti-tumor immune response
Tumor ablation induced anti-tumor immunity: destruction of the tumor in situ with the aim to evoke a robust anti-tumor immune response
Coley, W. B. (1893). The treatment of malignant tumors by repeated inoculations of erysipelas: With a report of ten origin...
Epigenetic regulation of breast cancer metastasis
Epigenetic regulation of breast cancer metastasis
Breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among w...
Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications
Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications
Extracellular vesicles (EVs) are small lipid bilayer–enclosed vesicles that mediate vital cellular communication by ...
Sam68 is a druggable vulnerability point in cancer stem cells
Sam68 is a druggable vulnerability point in cancer stem cells
Sam68 (Src associated in mitosis of 68 kDa) is an RNA-binding and multifunctional protein extensively characteriz...
Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review
Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. A...
Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and is implicated in the mult...
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