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Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma
Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma
Most early-stage ccRCC is easy to be ignored since it has no clinical symptoms, and most patients are detected through phy...
The loss of antioxidant activities impairs intestinal epithelium homeostasis by altering lipid metabolism
The loss of antioxidant activities impairs intestinal epithelium homeostasis by altering lipid metabolism
Accumulation of cellular damage, inflammation and loss of regenerative capacity are major challenges that tissues have to ...
Tumor-derived exosomal hyaluronidase 1 induced M2 macrophage polarization and promoted esophageal cancer progression
Tumor-derived exosomal hyaluronidase 1 induced M2 macrophage polarization and promoted esophageal cancer progression
Esophageal cancer (EC) ranks eighth among the most common cancers in the world. There are two main histological subtypes o...
The KDM5 inhibitor PBIT reduces proliferation of castration-resistant prostate cancer cells via cell cycle arrest and the induction of senescence
The KDM5 inhibitor PBIT reduces proliferation of castration-resistant prostate cancer cells via cell cycle arrest and the induction of senescence
The compound 2–4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one (PBIT) is an inhibitor of the KDM5 family of lysine-specific...
METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m6A modification
METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m6A modification
Preeclampsia is defined as the early event of hypertensive pregnancy with systolic blood pressure ≥140 mmHg and diastolic ...
Single-cell tracking as a tool for studying EMT-phenotypes
Single-cell tracking as a tool for studying EMT-phenotypes
KeywordsEpithelial-mesenchymal transitionSingle-cell trackingCell migrationViabilityMorphologyInheritanceData availability...
Targeting inhibitor of apoptosis proteins (IAPs) enhances susceptibility of oral squamous carcinoma cells to cisplatin
Targeting inhibitor of apoptosis proteins (IAPs) enhances susceptibility of oral squamous carcinoma cells to cisplatin
Oral Squamous Cell Carcinoma (OSCC) is currently the 6th most common type of cancer worldwide. It is generally aggressive ...
Exosomes derived from human umbilical cord mesenchymal stem cells pretreated by monosialoteterahexosyl ganglioside alleviate intracerebral hemorrhage by down-regulating autophagy
Exosomes derived from human umbilical cord mesenchymal stem cells pretreated by monosialoteterahexosyl ganglioside alleviate intracerebral hemorrhage by down-regulating autophagy
Intracerebral hemorrhage (ICH) can lead to the loss of neuronal cells through the response to the hematoma and the release...
Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage
Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage
Miscarriage, also termed spontaneous abortion, is one of the most frequent complications during gestation, and approximate...
Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway
Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway
Hypospadias is a congenital external genital malformation in which the urethral folds are incompletely fused, resulting in...
Botulinum toxin type a blocks aquaporin 5 trafficking by decreasing synaptosomal-associated protein 23 in submandibular acinar cells
Botulinum toxin type a blocks aquaporin 5 trafficking by decreasing synaptosomal-associated protein 23 in submandibular acinar cells
Aquaporin 5 (AQP5) is a water channel protein that modulates transcellular water permeability and plays an important role ...
The m6A methyltransferase RBM15 affects tumor cell stemness and progression of cervical cancer by regulating the stability of lncRNA HEIH
The m6A methyltransferase RBM15 affects tumor cell stemness and progression of cervical cancer by regulating the stability of lncRNA HEIH
Cervical cancer (CC), as a common female malignant tumor in the world, is an important risk factor endangering the health ...
RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway
RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway
Osteosarcoma (OS) is one of the most common malignant bone tumors in children and adolescents, accounting for approximatel...
ICBP90, an epigenetic regulator, induces DKK3 promoter methylation, promotes glioma progression, and reduces sensitivity to cis-platinum
ICBP90, an epigenetic regulator, induces DKK3 promoter methylation, promotes glioma progression, and reduces sensitivity to cis-platinum
Glioma is the most common primary tumor in central nervous system neoplastic diseases, often manifested as high malignancy...
Synovia tissue-specific exosomes participate in the dual variation of the osteoarthritis microenvironment via miR-182
Synovia tissue-specific exosomes participate in the dual variation of the osteoarthritis microenvironment via miR-182
Osteoarthritis (OA) is the most common type of joint disease worldwide, characterized by joint pain, and limited mobility....
Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation
Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation
The cellular microenvironment plays a crucial role in tissue growth and homeostasis and is closely linked to disease devel...
Corrigendum to TWIST2 inhibits EMT and induces oxidative stress of lung cancer cells by regulating FGF21-mediated AMPK/mTOR pathway [Exp. Cell Res. 2021 Aug 1;405(1):112661/ECR-21-80]
Corrigendum to TWIST2 inhibits EMT and induces oxidative stress of lung cancer cells by regulating FGF21-mediated AMPK/mTOR pathway [Exp. Cell Res. 2021 Aug 1;405(1):112661/ECR-21-80]
Volume 436, Issue 2, 15 March 2024, 113782Author links open overlay panelYingjian Song a 1, Wei Zhang a 1, Jiuxu Zhang b, ...
High level 27-HC impairs trophoblast cell invasion and migration via LXR in pre-eclampsia
High level 27-HC impairs trophoblast cell invasion and migration via LXR in pre-eclampsia
The placenta, a vital organ for both the fetus and the mother, participates in mediating their health [1]. The formation o...
ALKBH5-mediated upregulation of CPT1A promotes macrophage fatty acid metabolism and M2 macrophage polarization, facilitating malignant progression of colorectal cancer
ALKBH5-mediated upregulation of CPT1A promotes macrophage fatty acid metabolism and M2 macrophage polarization, facilitating malignant progression of colorectal cancer
m6A modification has been studied in tumors, but its role in host anti-tumor immune response and TAMs polarization remains...
Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1
Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1
As the primary cause of cancer-related deaths, cancer metastasis is a complicated process in which multiple signal pathway...
LRP5 competes for SPOP binding to enhance tumorigenesis mediated by Daxx and PD-L1 in prostate cancer
LRP5 competes for SPOP binding to enhance tumorigenesis mediated by Daxx and PD-L1 in prostate cancer
Genetic factors coordinate with environmental factors to drive the pathogenesis of prostate adenocarcinoma (PRAD). SPOP is...
Mechanism of pro-MMP9 activation in co-culture of pro-inflammatory macrophages and cardiomyocytes
Mechanism of pro-MMP9 activation in co-culture of pro-inflammatory macrophages and cardiomyocytes
ObjectiveA wide range of cardiac diseases is associated with inflammation. “Inflamed” heart tissue is infiltrated with pro...
Manipulating HGF signaling reshapes the cirrhotic liver niche and fills a therapeutic gap in regeneration mediated by transplanted stem cells
Manipulating HGF signaling reshapes the cirrhotic liver niche and fills a therapeutic gap in regeneration mediated by transplanted stem cells
Liver cirrhosis (LC) is a serious health problem worldwide, and the only therapeutic option is orthotopic liver transplant...
Salinomycin and IR780-loaded upconversion nanoparticles influence biological behavior of liver cancer stem cells by persistently activating the MAPK signaling pathway
Salinomycin and IR780-loaded upconversion nanoparticles influence biological behavior of liver cancer stem cells by persistently activating the MAPK signaling pathway
Liver cancer stem cells (LCSCs) constitute a distinct subset within liver cancer, possessing the remarkable ability of sel...
Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy
Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy
Epilepsy is a neurological disorder characterized by recurrent seizures, resulting from abnormal brain activity [1]. Vario...
miR-130b regulates B cell proliferation via CYLD-mediated NF-κB signaling
miR-130b regulates B cell proliferation via CYLD-mediated NF-κB signaling
B cells play an important role in host immunity. B cell activation is initiated by the antigen recognition of the B cell r...
Upregulated Tβ4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice
Upregulated Tβ4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice
The intestinal barrier, comprised of a mucus layer (chemical barrier), cell layer (mechanical barrier), and lamina propria...
Insulin promotes growth in breast cancer cells through the type I IGF receptor in insulin receptor deficient cells
Insulin promotes growth in breast cancer cells through the type I IGF receptor in insulin receptor deficient cells
Breast cancer is the most common cancer in women. The upregulation of insulin-like growth factor (IGF) system observed in ...
Advances in bi-directional relationships for EZH2 and oxidative stress
Advances in bi-directional relationships for EZH2 and oxidative stress
Over the past two decades, polycomb repressive complex 2(PRC2) has emerged as a vital repressive complex in overall cell f...
Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells
Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells
Intracellular lipid droplets (LDs) are ubiquitous organelles found in many cell types. During mitosis, membranous organell...
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