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Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
We previously described a nucleolar protein RSL1D1 but distributed throughout the nucleus in HCT116 colorectal cancer (CRC...
Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
Although the transcriptional regulation of the programmed death ligand 1 (PD-L1) promoter has been extensively studied, th...
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
Among follicular-derived thyroid cancers (TC), those with aggressive behavior and resistance to current treatments display...
Molecular mechanisms in colitis-associated colorectal cancer
Molecular mechanisms in colitis-associated colorectal cancer
Sustained chronic inflammation of the large intestine leads to tissue damage and repair, which is associated with an incre...
Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway
Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway
Beta1,4-galactosyltransferases (B4GALTs) play a crucial role in several diseases, including cancer. B4GALT1 is highly expr...
Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16
Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16
Although many studies have compared tumor fibroblasts (T-Fbs) and nontumor fibroblasts (N-Fbs), less is understood about t...
Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance
Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance
Triple negative breast cancer (TNBC) is defined as lacking the expressions of estrogen receptor (ER), progesterone recepto...
Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcrip...
Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma
Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma
The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is frequently reported to be hyperactivated in he...
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2
Lymph node (LN) metastasis is one of the key prognostic factors in bladder cancer, but its underlying mechanisms remain un...
AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
AIFM2 is a crucial NADH oxidase involved in the regulation of cytosolic NAD+. However, the role of AIFM2 in the progressio...
Discovery of neddylation E2s inhibitors with therapeutic activity
Discovery of neddylation E2s inhibitors with therapeutic activity
Neddylation is the writing of monomers or polymers of neural precursor cells expressed developmentally down-regulated 8 (N...
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Sex and gender disparities in bladder cancer have long been a subject of interest to the cancer research community, wherei...
Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer
Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer
Lethal prostate cancer (PCa) is characterized by the presence of metastases and development of resistance to therapies. Me...
SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer
SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer
Colorectal cancer (CRC) is a formidable disease due to the intricate mechanisms that drive its proliferation and metastasi...
Loss of Pkd1 limits susceptibility to colitis and colorectal cancer
Loss of Pkd1 limits susceptibility to colitis and colorectal cancer
Colorectal cancer (CRC) is one of the most common cancers, with an annual incidence of ~135,000 in the US, associated with...
Retraction Note: Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming
Correction: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade
Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade
Immune checkpoint blockade (ICB) therapies have brought unprecedented advances in cancer treatment, but responses are limi...
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
The tumor suppressor and chromatin modifier cAMP response element-binding protein binding protein (CREBBP) and v-myc avian...
MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5
MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5
MLK4, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, has been implicated in cancer progres...
Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12
Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12
Cancer relapse and metastasis are major obstacles for effective treatment. One important mechanism to eliminate cancer cel...
Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response
Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoiet...
WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines
WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines
Collectively, the MYC family of oncoprotein transcription factors is overexpressed in more than half of all malignancies. ...
Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma
Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma
Tumor thrombus of bone sarcomas represents a unique reservoir for various types of cancer and immune cells, however, the i...
Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity
Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity
Chemotherapy remains the mainstay of treatment for patients with advanced liposarcoma (LPS), but response rates are only 2...
CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer
CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer
Immune-checkpoint (IC) modulators like the poliovirus receptor (PVR) and programmed death ligand 1 (PD-L1) attenuate innat...
Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data
Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data
In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in inte...
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