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Evaluation of the association between lymph node ratio and long-term survival in patients after surgery for lymph node-positive bladder cancer: a SEER population-based study with external validation
Evaluation of the association between lymph node ratio and long-term survival in patients after surgery for lymph node-positive bladder cancer: a SEER population-based study with external validation
The lymph node ratio (LNR) has been recognized as an emerging prognostic biomarker in various malignant tumors. Our study ...
Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids
Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids
This study aimed to analyze the functional role of Brd4 in colorectal cancer (CRC) organoids. Brd4 was identified as a CRC...
The impact of oxidative balance on all-cause and cause-specific mortality in US adults and cancer survivors: evidence from NHANES 2001–2018
The impact of oxidative balance on all-cause and cause-specific mortality in US adults and cancer survivors: evidence from NHANES 2001–2018
Oxidative stress is a crucial pathophysiological mechanism in chronic diseases and mortality. While individual oxidative m...
Utilizing sc-linker to integrate single-cell RNA sequencing and human genetics to identify cell types and driver genes associated with non-small cell lung cancer
Utilizing sc-linker to integrate single-cell RNA sequencing and human genetics to identify cell types and driver genes associated with non-small cell lung cancer
Genome-wide association studies (GWAS) provide a powerful method for identifying the loci and genes that contribute to dis...
Nomogram incorporating Epstein-Barr virus DNA and a novel immune-nutritional marker for survival prediction in nasopharyngeal carcinoma
Nomogram incorporating Epstein-Barr virus DNA and a novel immune-nutritional marker for survival prediction in nasopharyngeal carcinoma
Since Immune response, nutritional status and Epstein–Barr Virus (EBV) DNA status have been confirmed to be relevant...
CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway
CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway
CD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer...
Impact of perioperative decreased serum albumin level on anastomotic leakage in esophageal squamous cell carcinoma patients treated with neoadjuvant chemotherapy followed by minimally invasive esophagectomy
Impact of perioperative decreased serum albumin level on anastomotic leakage in esophageal squamous cell carcinoma patients treated with neoadjuvant chemotherapy followed by minimally invasive esophagectomy
Anastomotic leakage (AL) is a severe complication following esophagectomy with high mortality. Perioperative decreased ser...
Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer
Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer
Breast cancer (BC) patients tend to suffer from distant metastasis, especially bone metastasis. All the analysis based on ...
Immediate histologic correlation in patients with different HPV genotypes and ages: a single center analysis in China
Immediate histologic correlation in patients with different HPV genotypes and ages: a single center analysis in China
Human papillomavirus (HPV) has been confirmed as a major causative factor for malignant transformation of cervical epithel...
Dynamic profiling of immune microenvironment during anti-PD-1 immunotherapy for head and neck squamous cell carcinoma: the IPRICE study
Dynamic profiling of immune microenvironment during anti-PD-1 immunotherapy for head and neck squamous cell carcinoma: the IPRICE study
Immune checkpoint inhibitors of programmed cell death protein 1 (PD-1) represent a significant breakthrough in treating he...
Phase I dose escalation study and pilot efficacy analysis of LXI-15029, a novel mTOR dual inhibitor, in Chinese subjects with advanced malignant solid tumors
Phase I dose escalation study and pilot efficacy analysis of LXI-15029, a novel mTOR dual inhibitor, in Chinese subjects with advanced malignant solid tumors
The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role i...
A population-based analysis of hematological malignancies from a French-West-Indies cancer registry’s data (2009–2018)
A population-based analysis of hematological malignancies from a French-West-Indies cancer registry’s data (2009–2018)
A worldwide increased incidence of HM has been marked in recent decades. Therefore, to update epidemiological characterist...
Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1
Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1
Due to the high drug resistance of hepatocellular carcinoma (HCC), sorafenib has limited efficacy in the treatment of adva...
Significance of circulating tumor cells detection in tumor diagnosis and monitoring
Significance of circulating tumor cells detection in tumor diagnosis and monitoring
To detect circulating tumor cells (CTCs) in the peripheral blood of patients with tumor, and to analyze the significance o...
A novel patient-derived immortalised cell line of myxofibrosarcoma: a tool for preclinical drugs testing and the generation of near-patient models
A novel patient-derived immortalised cell line of myxofibrosarcoma: a tool for preclinical drugs testing and the generation of near-patient models
Myxofibrosarcoma is a rare malignant soft tissue sarcoma characterised by multiple local recurrence and can become of high...
A practical prognostic peripheral blood-based risk model for the evaluation of the likelihood of a response and survival of metastatic cancer patients treated with immune checkpoint inhibitors
A practical prognostic peripheral blood-based risk model for the evaluation of the likelihood of a response and survival of metastatic cancer patients treated with immune checkpoint inhibitors
Less than half of unselected metastatic cancer patients benefit from the immune checkpoint inhibitor (ICI) therapy. System...
Refining gastric cancer staging: examining the interplay between number and anatomical location of metastatic lymph nodes - a retrospective multi-institutional study
Refining gastric cancer staging: examining the interplay between number and anatomical location of metastatic lymph nodes - a retrospective multi-institutional study
The current gastric cancer staging system relies on the number of metastatic lymph nodes (MLNs) for nodal stage determinat...
Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients
Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients
Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphol...
Patient and physician perspectives on treatments for low-risk prostate cancer: a qualitative study
Patient and physician perspectives on treatments for low-risk prostate cancer: a qualitative study
Patients diagnosed with low-risk prostate cancer (PCa) are confronted with a difficult decision regarding whether to under...
A multicenter noninferior randomized controlled study of sentinel lymph node biopsy alone versus sentinel lymph node biopsy plus lymphadenectomy for patients with stage I endometrial cancer, INSEC trial concept
A multicenter noninferior randomized controlled study of sentinel lymph node biopsy alone versus sentinel lymph node biopsy plus lymphadenectomy for patients with stage I endometrial cancer, INSEC trial concept
Up to the present time, there has remained a lack of strong evidence as to whether sentinel lymph node biopsy can replace ...
Proteome-wide analysis reveals potential therapeutic targets for Colorectal cancer: a two-sample mendelian randomization study
Proteome-wide analysis reveals potential therapeutic targets for Colorectal cancer: a two-sample mendelian randomization study
Colorectal cancer (CRC) is a leading cause of cancer-related mortality, highlighting an unmet clinical need for more effec...
Can we use a simple blood test to reduce unnecessary adverse effects from radiotherapy by timely identification of radiotherapy-resistant rectal cancers? MeD-Seq rectal study protocol
Can we use a simple blood test to reduce unnecessary adverse effects from radiotherapy by timely identification of radiotherapy-resistant rectal cancers? MeD-Seq rectal study protocol
Chemoradiation therapy (CRT) followed by surgery is currently the standard of care to treat patients with locally advanced...
Hepatocellular carcinoma immune prognosis score predicts the clinical outcomes of hepatocellular carcinoma patients receiving immune checkpoint inhibitors
Hepatocellular carcinoma immune prognosis score predicts the clinical outcomes of hepatocellular carcinoma patients receiving immune checkpoint inhibitors
The predictive biomarkers of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) still need to be furthe...
Construction of a prognostic risk score model based on the ARHGAP family to predict the survival of osteosarcoma
Construction of a prognostic risk score model based on the ARHGAP family to predict the survival of osteosarcoma
Osteosarcoma (OS) is the most common primary malignancy of bone tumors. More and more ARHGAP family genes have been confir...
Temporal trends in age- and stage-specific incidence of colorectal adenocarcinomas in Germany
Temporal trends in age- and stage-specific incidence of colorectal adenocarcinomas in Germany
A national colorectal cancer (CRC) screening programme was launched in 2002 in Germany. A comprehensive evaluation of the ...
CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study
CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study
Breast cancer (BC) is one of the malignant diseases threatening the life and health of women worldwide. The CYP4B1 gene wa...
Correction: Phosphorylation of EZH2 differs HER2-positive breast cancer invasiveness in a site-specific manner
Correction: Phosphorylation of EZH2 differs HER2-positive breast cancer invasiveness in a site-specific manner
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Optimization of supraclavicular lymph node clinical target volume delineation in high-risk breast cancer: a single center experience and recommendation
Optimization of supraclavicular lymph node clinical target volume delineation in high-risk breast cancer: a single center experience and recommendation
Prophylactic irradiation of supraclavicular lymph node drainage areas can improve the regional control rate of lymph node-...
Dissemination feature based on PET/CT is a risk factor for diffuse large B cell lymphoma patients outcome
Dissemination feature based on PET/CT is a risk factor for diffuse large B cell lymphoma patients outcome
18F-FDG PET/CT provides precise information about dissemination of lymphoma lesions. Dmax, defined as distance between the...
Vaginal CO2 laser therapy for genitourinary syndrome in breast cancer survivors—VagLaser study protocol: a randomized blinded, placebo-controlled trial
Vaginal CO2 laser therapy for genitourinary syndrome in breast cancer survivors—VagLaser study protocol: a randomized blinded, placebo-controlled trial
Vaginal CO2 laser therapy is a new treatment option for genitourinary syndrome of menopause. Its potential is particularly...
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