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Chaperoning RNA into granules
Biomolecular condensate formation requires multivalent interactions and rapid turnover. Stress granules are condensates fo...
Real-time mirroring of therapy
Early assessment of treatment efficacy can be invaluable in cases of aggressive tumours, such as glioblastoma. Logun et al...
Battling Diamond-Blackfan anaemia
Gene therapy strategies against Diamond-Blackfan anaemia (DBA) have been hampered by the multiple and heterogeneous causat...
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Adapting to improve the author experience
Here we discuss approaches to refine our editorial processes.
Mitochondrial protein import stress
Mitochondrial protein import stress
Mitochondria have to import a large number of precursor proteins from the cytosol. Chaperones keep these proteins in a lar...
Multiomics reveals that triacylglycerol mobilization helps drive recovery from mitochondrial stress
Multiomics reveals that triacylglycerol mobilization helps drive recovery from mitochondrial stress
We devised a multiomics strategy to identify metabolic pathways used by yeast to surmount mitochondrial stress. Strains ca...
Author Correction: Co-option of epidermal cells enables touch sensing
Author Correction: Co-option of epidermal cells enables touch sensing
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
These authors contributed equally: Xiaoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding, Linge Li.These autho...
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Lineage transitions are a central feature of prostate development, tumorigenesis and treatment resistance. We discovered t...
Metabolically regulated lineages in prostate cancer
Metabolically regulated lineages in prostate cancer
Lineage plasticity and epigenetic changes underlie prostate development and cancer evolution. A new study shows that basal...
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and treatment resistance. While epigenet...
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Myeloid cell infiltration of solid tumours generally associates with poor patient prognosis and disease severity1–13...
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids
Gene expression is regulated by multiple epigenetic mechanisms, which are coordinated in development and disease. However,...
COPIng with senescence
COPIng with senescence
There is increasing interest in approaches that target and eliminate senescent cells. A study reports that the coatomer co...
Author Correction: Changing the public perception of human embryology
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, AustriaNi...
Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (mye...
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells
Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer, fibrosis and age-related diseases...
Manganese controls lipoprotein secretion via biomolecular condensation
Manganese controls lipoprotein secretion via biomolecular condensation
By regulating the condensation of the molecular transport machinery coat protein complex II (COPII), manganese ions contri...
Quick tips for interpreting cell death experiments
Quick tips for interpreting cell death experiments
Cell death is an important biological process whose experimental detection and measurement can be difficult, especially wh...
Changing the public perception of human embryology
Human embryology is flourishing thanks to an impetus provided by embryo models formed from stem cells. These scientific ad...
Cytosolic transfer of circulating LPS by EVs
Cytosolic transfer of circulating LPS by EVs
The main barriers for intracellular receptors to sense circulating pathogen-associated molecular patterns (PAMPs) is how t...
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis
Intracellular surveillance for systemic microbial components during homeostasis and infections governs host physiology and...
Scarless healing
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Condensing to target RNAs
Biomolecular condensates are found throughout eukaryotic cells and may be involved in a large range of biological processe...
Storing exogenous DNA
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Sperm bud mitochondria to adjust the numbers
Sperm bud mitochondria to adjust the numbers
Cells use diverse mechanisms to rid themselves of dysfunctional or excess mitochondria. A study now shows that C. elegans ...
O-GlcNAc regulates YTHDF1 and YTHDF3 activity
O-GlcNAc regulates YTHDF1 and YTHDF3 activity
YTHDF family members are ‘readers’ of a common mRNA modification, but their effects on mRNA translation and st...
Towards inclusive and sustainable scientific meetings
Conferences are often held at different venues and feature innovative scientific programs; however, their design rarely ch...
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis
Breast cancer brain metastasis (BCBM) is a lethal disease with no effective treatments. Prior work has shown that brain ca...
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