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Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p‐JNK MAPK pathway
Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p‐JNK MAPK pathway
Abstract Hypoxic pulmonary hypertension (HPH) is characterized by elevated pulmonary artery resistance and vascular remode...
Carboxyl terminus of HSP70‐interacting protein attenuates advanced glycation end products‐induced cardiac injuries by promoting NFκB proteasomal degradation
Carboxyl terminus of HSP70‐interacting protein attenuates advanced glycation end products‐induced cardiac injuries by promoting NFκB proteasomal degradation
Abstract Advanced glycation end products (AGEs), which are highly reactive molecules resulting from persistent high-glucos...
Cover Image, Volume 236, Number 12, December 2021
Cover Image, Volume 236, Number 12, December 2021
Front Cover: The cover image is based on the Research Article αB-crystallin/hspB2 are critical for hyperactive mTOR-...
Heliothis virescens ascovirus 3h blocks the cell cycle of Spodoptera exigua fat body cells at G2/M phase by downregulating cyclin B1 and cyclin‐dependent kinase 1
Heliothis virescens ascovirus 3h blocks the cell cycle of Spodoptera exigua fat body cells at G2/M phase by downregulating cyclin B1 and cyclin‐dependent kinase 1
Abstract Ascoviruses are double-stranded DNA viruses that are pathogenic to noctuid larvae. In vitro infection causes the ...
von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation
von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation
Abstract Cell- and tissue-specific extracellular matrix (ECM) composition plays an important role in organ development, in...
Prostaglandin signaling in ciliogenesis and development
Prostaglandin signaling in ciliogenesis and development
Abstract Prostaglandin (PG) signaling regulates a wide variety of physiological and pathological processes, including body...
Murburn precepts for lactic‐acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen
Murburn precepts for lactic‐acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen
Abstract It is unresolved why lactate is transported to the liver for further utilization within the physiological purview...
Follicular dendritic cells
Follicular dendritic cells
Abstract Follicular dendritic cells (FDCs) are unique accessory immune cells that contribute to the regulation of humoral ...
Piezo1 controls cell volume and migration by modulating swelling‐activated chloride current through Ca2+ influx
Piezo1 controls cell volume and migration by modulating swelling‐activated chloride current through Ca2+ influx
Abstract Regulatory volume decrease (RVD), a homeostatic process responsible for the re-establishment of the original cell...
RNA N6‐methyladenosine in nonocular and ocular disease
RNA N6‐methyladenosine in nonocular and ocular disease
Abstract N6-methyladenosine (m6A), the sixth N methylation of adenylate (A) in RNA, is the most abundant transcriptome mod...
Isolation and functional analysis of OsAOS1 promoter for resistance to Nilaparvata lugens Stål infestation in rice
Isolation and functional analysis of OsAOS1 promoter for resistance to Nilaparvata lugens Stål infestation in rice
Abstract Insect pests have a great impact on the yield and quality of crops. Insecticide applications are an effective met...
In vivo evidence for the cellular basis of central hypoventilation of Rett syndrome and pharmacological correction in the rat model
In vivo evidence for the cellular basis of central hypoventilation of Rett syndrome and pharmacological correction in the rat model
Abstract Rett syndrome (RTT) is a neurodevelopmental disorder caused mostly by mutations in the MECP2 gene. RTT patients s...
Molecular structure, expression, and the emerging role of Siglec‐15 in skeletal biology and cancer
Molecular structure, expression, and the emerging role of Siglec‐15 in skeletal biology and cancer
Abstract Siglec-15, a Siglec family member and type-1 transmembrane protein, is expressed mainly in human macrophages and ...
Is there an emerging role for IKs in aging‐related ventricular arrhythmias?
Is there an emerging role for IKs in aging‐related ventricular arrhythmias?
Early View LETTER TO THE EDITOR Ademuyiwa S. Aromolaran, Corresponding Author ...
Lactobacillus plantarum alleviates irradiation‐induced intestinal injury by activation of FXR‐FGF15 signaling in intestinal epithelia
Lactobacillus plantarum alleviates irradiation‐induced intestinal injury by activation of FXR‐FGF15 signaling in intestinal epithelia
Abstract Abdominal irradiation (IR) may destroy the intestinal mucosal barrier, leading to severe intestinal infection and...
Melatonin attenuates reactive astrogliosis and glial scar formation following cerebral ischemia and reperfusion injury mediated by GSK‐3β and RIP1K
Melatonin attenuates reactive astrogliosis and glial scar formation following cerebral ischemia and reperfusion injury mediated by GSK‐3β and RIP1K
Abstract Even though astrocytes have been widely reported to support several brain functions, studies have emerged that th...
Tumor‐derived exosomal PD‐L1 in progression of cancer and immunotherapy
Tumor‐derived exosomal PD‐L1 in progression of cancer and immunotherapy
Abstract Cancer is a gravely important health issue all over the world and has been spreading fast. In recent years immune...
The expression pattern of β‐carotene ketolase gene restricts the accumulation of astaxanthin in Dunaliella under salt stress
The expression pattern of β‐carotene ketolase gene restricts the accumulation of astaxanthin in Dunaliella under salt stress
Abstract Dunaliella salina can accumulate a large amount of β-carotene which is generally considered to be its termi...
The role of trimethylamine‐N‐Oxide in the development of Alzheimer's disease
The role of trimethylamine‐N‐Oxide in the development of Alzheimer's disease
Abstract Alzheimer's disease is associated with multiple risk factors and is the most common type of dementia. Trimethylam...
The tooth‐specific basic helix‐loop‐helix factor AmeloD promotes differentiation of ameloblasts
The tooth‐specific basic helix‐loop‐helix factor AmeloD promotes differentiation of ameloblasts
Abstract Tissue-specific basic helix-loop-helix (bHLH) transcription factors play an important role in cellular differenti...
Cardiomyocyte‐GSK‐3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms
Cardiomyocyte‐GSK‐3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms
Abstract Cardiomyopathy is an irreparable loss and novel strategies are needed to induce resident cardiac progenitor cell ...
Overexpression of N‐acetylglucosaminyltransferase V promotes human parotid gland acinar cell immortalization via the epidermal receptor activation
Overexpression of N‐acetylglucosaminyltransferase V promotes human parotid gland acinar cell immortalization via the epidermal receptor activation
Abstract The purpose of this study is to maintain the proliferation capability of human parotid gland acinar cells (ACs) i...
Potential key factors involved in regulating adipocyte dedifferentiation
Potential key factors involved in regulating adipocyte dedifferentiation
Abstract Adipocytes are the key constituents of adipose tissue, and their de-differentiation process has been widely obser...
CircRNA–miRNA networks in regulating bone disease
CircRNA–miRNA networks in regulating bone disease
Abstract Circular RNA (circRNA) is a class of endogenous noncoding RNA (ncRNA), presenting as a special covalent closed lo...
Roburic acid attenuates osteoclastogenesis and bone resorption by targeting RANKL‐induced intracellular signaling pathways
Roburic acid attenuates osteoclastogenesis and bone resorption by targeting RANKL‐induced intracellular signaling pathways
Abstract Excessive activity of osteoclasts contributes to skeletal diseases such as osteoporosis and osteolysis. However, ...
Targeting hypoxia and hypoxia‐inducible factor‐1 in the tumor microenvironment for optimal cancer immunotherapy
Targeting hypoxia and hypoxia‐inducible factor‐1 in the tumor microenvironment for optimal cancer immunotherapy
Abstract The development of new strategies of anticancer immunotherapies has provided promising approaches in the treatmen...
Citral alleviates peptidoglycan‐induced inflammation and disruption of barrier functions in porcine intestinal epithelial cells
Citral alleviates peptidoglycan‐induced inflammation and disruption of barrier functions in porcine intestinal epithelial cells
Abstract Peptidoglycan (PGN) is a major polymer in bacterial cell walls and may constrain gut functionality and lower inte...
CORRIGENDUM: Reduced LINC00551 expression promotes proliferation and invasion of esophageal squamous cancer by increase in HSP27 phosphorylation
CORRIGENDUM: Reduced LINC00551 expression promotes proliferation and invasion of esophageal squamous cancer by increase in HSP27 phosphorylation
[Article in the Journal of Cellular Physiology. https://doi.org/10.1002/jcp.29947] Article first publis...
Role of autophagy in intervertebral disc degeneration
Role of autophagy in intervertebral disc degeneration
Abstract Intervertebral disc degeneration (IDD) is a leading contributor to low back pain. The intervertebral disc (IVD) i...
Age‐related changes in the energy of human mesenchymal stem cells
Age‐related changes in the energy of human mesenchymal stem cells
Abstract Aging is a physiological process that leads to a higher risk for the most devastating diseases. There are a numbe...
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