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Preprint Highlight: LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition
Preprint Highlight: LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition
Mutations in the leucine-rich repeat kinase 2 (LRRK2) that increase kinase activity are associated with some forms of Park...
A novel tool for the unbiased characterization of epithelial monolayer development in culture
A novel tool for the unbiased characterization of epithelial monolayer development in culture
The function of an epithelial tissue is intertwined with its architecture. Epithelial tissues are often described as pseud...
Targeting of Hmo1 to subcompartments of the budding yeast nucleolus
Targeting of Hmo1 to subcompartments of the budding yeast nucleolus
The nucleolus is a multi-layered, membrane-less organelle made up of liquid-like biogenesis compartments surrounding an ar...
Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice
Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice
To survive poor nutritional conditions, tumor cells activate the unfolded protein response, which is composed of the IRE1,...
Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality
Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality
Cells sense and migrate across mechanically dissimilar environments throughout development and disease progression. Howeve...
Spatio-temporal regulation of endocytic protein assembly by SH3 domains in yeast
Spatio-temporal regulation of endocytic protein assembly by SH3 domains in yeast
Clathrin-mediated endocytosis is a conserved eukaryotic membrane trafficking pathway that is driven by a sequentially asse...
Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia
Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia
The primary cilium is a nexus for cell signaling and relies on specific protein trafficking for function. The tubby family...
Expanding ring-shaped cleavage furrows in multi-nucleate cells
Expanding ring-shaped cleavage furrows in multi-nucleate cells
Multi-nucleate cells of Dictyostelium discoideum divide usually by unilateral cleavage furrows that ingress from the cell ...
KLHL12 can form large COPII structures in the absence of CUL3 neddylation
KLHL12 can form large COPII structures in the absence of CUL3 neddylation
CUL3-RING ubiquitin ligases (CRL3s) are involved in various cellular processes through different Bric a brac, Tramtrack an...
A salt bridge-mediated resistance mechanism to FtsZ inhibitor PC190723 revealed by a cell-based screen
A salt bridge-mediated resistance mechanism to FtsZ inhibitor PC190723 revealed by a cell-based screen
Bacterial cell division proteins, especially the tubulin homolog FtsZ, have emerged as strong targets for developing new a...
2022 ASCB Annual Meeting abstracts
2022 ASCB Annual Meeting abstracts
© 2023 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under l...
Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila
Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila
Tetrahymena thermophila possesses arrays of motile cilia that promote fluid flow for cell motility. These consist of intri...
The Scaffold RhoGAP Protein ARHGAP8/ BPGAP1 Synchronizes Rac and Rho Signaling to Facilitate Cell Migration
The Scaffold RhoGAP Protein ARHGAP8/ BPGAP1 Synchronizes Rac and Rho Signaling to Facilitate Cell Migration
Rho GTPases regulate cell morphogenesis and motility under the tight control of guanine-nucleotide exchange factors (GEFs)...
Differentiation-dependent changes in Lamin B1 dynamics and Lamin B Receptor localization
Differentiation-dependent changes in Lamin B1 dynamics and Lamin B Receptor localization
The nuclear lamina serves important roles in chromatin organization and structural support, and lamina mutations can resul...
Chimeric a-subunit isoforms generate functional yeast V-ATPases with altered regulatory properties in vitro and in vivo
Chimeric a-subunit isoforms generate functional yeast V-ATPases with altered regulatory properties in vitro and in vivo
V-ATPases are highly regulated proton pumps that acidify organelles. The V-ATPase a-subunit is a two-domain protein contai...
CLASP2 facilitates dynamic actin filament organization along the microtubule lattice
CLASP2 facilitates dynamic actin filament organization along the microtubule lattice
Coordination between the microtubule and actin networks is essential for cell motility, neuronal growth cone guidance, and...
In vivo imaging reveals independent intraflagellar transport of the nexin-dynein regulatory complex subunits DRC2 and DRC4
In vivo imaging reveals independent intraflagellar transport of the nexin-dynein regulatory complex subunits DRC2 and DRC4
Many axonemal proteins enter cilia and flagella on intraflagellar transport (IFT) trains, which move bidirectionally along...
Katnip is required to maintain microtubule function and lysosomal delivery to autophagosomes and phagosomes
Katnip is required to maintain microtubule function and lysosomal delivery to autophagosomes and phagosomes
The efficient delivery of lysosomes is essential for many cell functions, such as the degradation of unwanted intracellula...
Coordinated efforts of different actin filament populations are needed for optimal cell wound repair
Coordinated efforts of different actin filament populations are needed for optimal cell wound repair
Cells are subjected to a barrage of daily insults that often lead to their cortex being ripped open and requiring immediat...
Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion
Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion
We previously identified the mechanistic Target of Rapamycin Complex 2 (mTORC2) as an effector of Ras for the control of d...
Role of intraflagellar transport in transcriptional control during flagellar regeneration in Chlamydomonas
Role of intraflagellar transport in transcriptional control during flagellar regeneration in Chlamydomonas
Biosynthesis of organelle precursors is a central part of the organelle size control problem, but what systems are require...
SWR1 Chromatin Remodeling Complex Prevents Mitotic Slippage during Spindle Position Checkpoint Arrest
SWR1 Chromatin Remodeling Complex Prevents Mitotic Slippage during Spindle Position Checkpoint Arrest
Faithful chromosome segregation in budding yeast requires correct positioning of the mitotic spindle along the mother to d...
An approach for quantitative mapping of synaptic periactive zone architecture and organization
An approach for quantitative mapping of synaptic periactive zone architecture and organization
Following exocytosis at active zones, synaptic vesicle membranes and membrane-bound proteins must be recycled. The endocyt...
Preprint Highlight: A lysosomal lipid transport pathway that enables cell survival under choline limitation
Preprint Highlight: A lysosomal lipid transport pathway that enables cell survival under choline limitation
Lysosomes maintain cellular homeostasis by clearing macromolecules and recycling their content to support the cell's needs...
Preprint Highlight: Quantitative multiplexed imaging of chromatin ultrastructure with Decode-PAINT
Preprint Highlight: Quantitative multiplexed imaging of chromatin ultrastructure with Decode-PAINT
Recent innovations have advanced our understanding of how the 3D organization of chromosomes regulates nuclear processes s...
Aberrant Caveolin-1-Mediated Smad Signaling and Proliferation Identified by Analysis of Adenine 474 Deletion Mutation (c.474delA) in Patient Fibroblasts: A New Perspective in the Mechanism of Pulmonary Hypertension
Aberrant Caveolin-1-Mediated Smad Signaling and Proliferation Identified by Analysis of Adenine 474 Deletion Mutation (c.474delA) in Patient Fibroblasts: A New Perspective in the Mechanism of Pulmonary Hypertension
A heterozygous Caveolin-1 c.474delA mutation has been identified in a family with heritable pulmonary arterial hypertensio...
Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation
Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation
The nucleus houses, organizes, and protects chromatin to ensure genome integrity and proper gene expression, but how the n...
The ring saga: looking back at the discovery of γ-tubulin and γ-tubulin ring complexes
The ring saga: looking back at the discovery of γ-tubulin and γ-tubulin ring complexes
For many years, two central, unanswered questions in cytoskeleton research were how microtubule assembly is nucleated and ...
Loss-of-function approach using mouse retinal explants showed pivotal roles of Nmnat2 in early and middle stages of retinal development
Loss-of-function approach using mouse retinal explants showed pivotal roles of Nmnat2 in early and middle stages of retinal development
Nicotinamide mononucleotide adenylyltransferase (Nmnat) is a group of enzymes consisting of three members (Nmnat1-3). shRN...
Protein biosynthesis at the ER: finding the right accessories
Protein biosynthesis at the ER: finding the right accessories
More than 30% of eukaryotic proteins contain domains that must translocate across or integrate into the endoplasmic reticu...
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