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Reduced M2 macrophages and adventitia collagen dampen the structural integrity of blood blister–like aneurysms and induce preoperative rerupture
Reduced M2 macrophages and adventitia collagen dampen the structural integrity of blood blister–like aneurysms and induce preoperative rerupture
Abstract Objective Blood blister–like aneurysms (BBAs) are extremely rare aneurysms. They are predisposed to preope...
Suppression of adult cytogenesis in the rat brain leads to sex‐differentiated disruption of the HPA axis activity
Suppression of adult cytogenesis in the rat brain leads to sex‐differentiated disruption of the HPA axis activity
Abstract Objectives The action of stress hormones, mainly glucocorticoids, starts and coordinates the systemic response to...
Glycomics reveal that ST6GAL1‐mediated sialylation regulates uterine lumen closure during implantation
Glycomics reveal that ST6GAL1‐mediated sialylation regulates uterine lumen closure during implantation
Abstract Objectives Implantation failure is a major cause of prenatal mortality. The uterine lumen closure contributes to ...
Substrate stiffness regulates the differentiation profile and functions of osteoclasts via cytoskeletal arrangement
Substrate stiffness regulates the differentiation profile and functions of osteoclasts via cytoskeletal arrangement
Abstract Objectives Aging and common diseases alter the stiffness of bone tissue, causing changes to the microenvironment ...
LncRNA‐AK137033 inhibits the osteogenic potential of adipose‐derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation
LncRNA‐AK137033 inhibits the osteogenic potential of adipose‐derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation
Abstract Objectives Bone tissue engineering based on adipose-derived stem cells (ASCs) is expected to become a new treatme...
ClC‐c regulates the proliferation of intestinal stem cells via the EGFR signalling pathway in Drosophila
ClC‐c regulates the proliferation of intestinal stem cells via the EGFR signalling pathway in Drosophila
Abstract Objectives Adult stem cells uphold a delicate balance between quiescent and active states, which is crucial for t...
Understanding of mouse and human bladder at single‐cell resolution: integrated analysis of trajectory and cell‐cell interactive networks based on multiple scRNA‐seq datasets
Understanding of mouse and human bladder at single‐cell resolution: integrated analysis of trajectory and cell‐cell interactive networks based on multiple scRNA‐seq datasets
Abstract Objectives To elaborately decipher the mouse and human bladders at single-cell levels. Materials and Methods We c...
Requirements for human haematopoietic stem/progenitor cells
Requirements for human haematopoietic stem/progenitor cells
Abstract ‘Requirements for human haematopoietic stem/progenitor cells’ is the first set of guidelines on hum...
Requirments for primary human hepatocyte
Requirments for primary human hepatocyte
Abstract ‘Requirements for Primary Human Hepatocyte’ is the first set of guidelines on Primary Human Hepatoc...
Human mesenchymal stem cells
Human mesenchymal stem cells
Abstract Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their...
Lipid raft involvement in signal transduction in cancer cell survival, cell death and metastasis
Lipid raft involvement in signal transduction in cancer cell survival, cell death and metastasis
Abstract Lipid rafts are cholesterol- and sphingolipid-enriched specialized membrane domains within the plasma membrane. L...
Research progress on the hedgehog signalling pathway in regulating bone formation and homeostasis
Research progress on the hedgehog signalling pathway in regulating bone formation and homeostasis
Abstract Bone formation is a complex regeneration process that was regulated by many signalling pathways, such as Wnt, Not...
Insights into roles of METTL14 in tumors
Insights into roles of METTL14 in tumors
Abstract N6-Methyladenosine (m6A) is considered the most common and endogenous modification of eukaryotic RNAs. Highly con...
Advances in single‐cell sequencing and its application to musculoskeletal system research
Advances in single‐cell sequencing and its application to musculoskeletal system research
Abstract In recent years, single-cell sequencing (SCS) technologies have continued to advance with improved operating proc...
Enhancing targeted transgene knock‐in by donor recruitment
Enhancing targeted transgene knock‐in by donor recruitment
With the development of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas91-based gene editing techno...
m6A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase‐specific transcripts
m6A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase‐specific transcripts
Abstract Objectives Accumulating evidences show that the regulatory network of m6A modification is essential for mammalian...
Comprehensive analysis of human chorionic membrane extracts regulating mesenchymal stem cells during osteogenesis
Comprehensive analysis of human chorionic membrane extracts regulating mesenchymal stem cells during osteogenesis
Abstract Objective Human chorionic membrane extracts (CMEs) from placenta are known to be a natural biomaterial for bone r...
YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation
YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation
Abstract Objectives YTHDF1 is known as a m6A reader protein, and many researches of YTHDF1 focused on the regulation of mR...
Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF‐1α/SLC7A11 pathway
Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF‐1α/SLC7A11 pathway
Abstract Objectives Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC activation and ECM a...
Human retinal pigment epithelial cells
Human retinal pigment epithelial cells
Abstract 'Human retinal pigment epithelial cells' is the first set of guidelines on human retinal pigment epithelial cells...
Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
Abstract Impaired apoptosis is one of the hallmarks of cancer, and almost all of the non-surgical approaches of eradicatin...
Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling
Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling
Abstract Objectives Previous reports have proposed the importance of signalling and material exchange between cartilage an...
Adiponectin receptor agonist AdipoRon blocks skin inflamm‐ageing by regulating mitochondrial dynamics
Adiponectin receptor agonist AdipoRon blocks skin inflamm‐ageing by regulating mitochondrial dynamics
Abstract Introduction Skin is susceptible to senescence-associated secretory phenotype (SASP) and inflamm-ageing partly ow...
LRRC8A is essential for volume‐regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension
LRRC8A is essential for volume‐regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension
Abstract Objectives Recent studies revealed LRRC8A to be an essential component of volume-regulated anion channel (VRAC), ...
Requirements for human cardiomyocytes
Requirements for human cardiomyocytes
Abstract ‘Requirements for human cardiomyocytes', jointly drafted and agreed upon by experts from the Chinese Socie...
Deletion of Nf2 in neural crest‐derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region‐ and stage‐specific manner
Deletion of Nf2 in neural crest‐derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region‐ and stage‐specific manner
Abstract Objectives The mammalian tongue develops from the branchial arches (1–4) and comprises highly organized ti...
MNSFβ regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness
MNSFβ regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness
Abstract Objectives Success in pregnancy in mammals predominantly depends on a well-developed placenta. The differentiatio...
Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5
Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5
Abstract Objectives SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1...
Circular RNAs in cell cycle regulation: Mechanisms to clinical significance
Circular RNAs in cell cycle regulation: Mechanisms to clinical significance
Abstract Circular RNAs (circRNAs), a type of non-coding RNA, are single-stranded circularized molecules characterized by h...
Bone marrow macrophage‐derived exosomal miR‐143‐5p contributes to insulin resistance in hepatocytes by repressing MKP5
Bone marrow macrophage‐derived exosomal miR‐143‐5p contributes to insulin resistance in hepatocytes by repressing MKP5
Abstract Objective In this study, we aim to explore the role of bone marrow macrophage-derived exosomes in hepatic insulin...
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