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Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity
Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity
Using a novel human tonsil immune organoid system, Chen et al. demonstrate that by controlling autoreactive humoral and ce...
Evasion of T cell responses by newly emerging SARS-CoV-2 variants
Evasion of T cell responses by newly emerging SARS-CoV-2 variants
We describe how newly emerging mutations in the SARS-CoV-2 variant BA.2.86 sub-variant JN.1 contribute to evasion of CD8+ ...
T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots
T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots
Although antibody escape is observed in emerging severe acute respiratory syndrome coronavirus 2 variants, T cell escape, ...
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs
Mucosal antigen-specific T cells are pivotal for pathogen clearance and immune modulation in respiratory infections. Dysre...
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa
Cell-type-specific SARS-CoV-2-induced responses in nasal mucosa differ largely between ancestral, Delta and Omicron cases,...
Single-cell profiling of the immune landscape across the human lifespan
Single-cell profiling of the immune landscape across the human lifespan
Using a combination of single-cell RNA sequencing, T cell and B cell receptor sequencing, and mass cytometry analyses, we ...
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
A comprehensive understanding of the evolution of the immune landscape in humans across the entire lifespan at single-cell...
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
γδ T cells producing either interleukin-17A (γδ17 cells) or interferon-γ (γδIFN cells) ...
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
The nature of activation signals is essential in determining T cell subset differentiation; however, the features that det...
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require ...
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Spleen marginal zone (MZ) B cells are important for antibody responses against blood-borne antigens. The signals they use ...
Publisher Correction: CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides
John DaviesPresent address: Department of Safety Assessment, Genentech, Inc., San Francisco, CA, USAChristian S. HinrichsP...
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more protective than vaccination or previo...
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection against heterologous pathogens. How...
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms
Author notesWen ZhouPresent address: BillionToOne, Menlo Park, CA, USAFan GaoPresent address: Lyterian Therapeutics, South...
Severe dengue progression beyond enhancement
Severe dengue progression beyond enhancement
The immune response to dengue virus infection is a well-coordinated balancing act. New research shows that an imbalanced r...
Cancer immunology leads the way
Cancer immunology research is diverse, uses cutting-edge technologies and continues to excite with its constantly evolving...
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that γδ T cell antigen re...
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consumin...
A second-generation M1-polarized CAR macrophage with antitumor efficacy
A second-generation M1-polarized CAR macrophage with antitumor efficacy
Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological malignancies. Macrophages have al...
The immunometabolic ecosystem in cancer
The immunometabolic ecosystem in cancer
Our increased understanding of how key metabolic pathways are activated and regulated in malignant cells has identified me...
Forks in the road for CAR T and CAR NK cell cancer therapies
Forks in the road for CAR T and CAR NK cell cancer therapies
The advent of chimeric antigen receptor (CAR) T cell therapy has resulted in unprecedented long-term clearance of relapse/...
BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin
BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin
Lymphocyte development consists of sequential and mutually exclusive cell states of proliferative selection and antigen re...
Gut Treg cells release IL-27 to regulate TH17 cell responses
Gut Treg cells release IL-27 to regulate TH17 cell responses
Interleukin-27 (IL-27) is a pleiotropic cytokine known for its diverse immune regulatory properties. Although innate immun...
A distinct subtype of stromal cell orchestrates the inflammatory response to tissue injury
A distinct subtype of stromal cell orchestrates the inflammatory response to tissue injury
After acute injury to skeletal muscle, an ‘early responder’ subtype of stromal cells rapidly produces an array...
IL-27 gives a good gut feeling about immune regulation
IL-27 gives a good gut feeling about immune regulation
Regulatory T (Treg) cells maintain the balance between immune protection and pathology. Research has now found that intest...
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides
CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides
The T cell antigen receptor (TCR) contains ten immunoreceptor tyrosine-based activation motif (ITAM) signaling sequences d...
CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity
CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity
Cancer cells often overexpress CD47, which triggers the inhibitory receptor SIRPα expressed on macrophages, to elude ...
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection
Regulatory T (Treg) cell modulation of adaptive immunity and tissue homeostasis is well described; however, less is known ...
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