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Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
Presence of autoantibodies against α-synuclein (α-syn AAb) in serum of the general population has been widely re...
IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve
IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve
The spinal inflammatory signal often spreads to distant segments, accompanied by widespread pain symptom under neuropathol...
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into h...
The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome
The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction an...
Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular ...
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Skull bone marrow is thought to be an immune tissue closely associated with the central nervous system (CNS). Recent studi...
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicat...
Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via t...
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B ...
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer&...
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concent...
Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including fron...
Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells
Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells
Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-re...
TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
Neuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). I...
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of pr...
OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
Inflammatory response triggered by innate immunity plays a pivotal element in the progress of ischemic stroke. Receptor-in...
Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury
Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury
Neonatal encephalopathy following hypoxia–ischemia (HI) is a leading cause of childhood death and morbidity. Hypothe...
Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1
Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1
Chronic activation and dysfunction of microglia have been implicated in the pathogenesis and progression of many neurodege...
Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case–control study
Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case–control study
Regulatory T cells (Tregs) are involved in the systemic immune response after ischemic stroke. However, their role remains...
14-3-3 \(\upzeta /\updelta\)-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2
14-3-3 \(\upzeta /\updelta\)-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2
Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer’s dis...
PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4
PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4
Luteolin is a flavonoid found in high concentrations in celery and green pepper, and acts as a neuroprotectant. PSMC5 (pro...
Protective role of IL-17-producing γδ T cells in a laser-induced choroidal neovascularization mouse model
Protective role of IL-17-producing γδ T cells in a laser-induced choroidal neovascularization mouse model
Vision loss in patients with wet/exudative age-related macular degeneration (AMD) is associated with choroidal neovascular...
Ly6C-high monocytes alleviate brain injury in experimental subarachnoid hemorrhage in mice
Ly6C-high monocytes alleviate brain injury in experimental subarachnoid hemorrhage in mice
Subarachnoid hemorrhage (SAH) is an uncommon type of potentially fatal stroke. The pathophysiological mechanisms of brain ...
Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model
Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model
Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin with antioxidant, anti-inflammatory, and antitumor properties. Howev...
Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology
Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology
Alzheimer’s disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum co...
Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood–brain barrier function
Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood–brain barrier function
Brain pericytes participate in the regulation of cerebral blood flow and the maintenance of blood–brain barrier inte...
Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo
Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo
Cerebral microhemorrhages (CMH) are associated with stroke, cognitive decline, and normal aging. Our previous study shows ...
Glyceryl triacetate promotes blood–brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice
Glyceryl triacetate promotes blood–brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice
Lipid metabolism has a crucial role in neural repair in neurodegenerative diseases. We recently revealed that lipogenesis-...
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