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Anti-Mesothelin CAR-NK cells as a novel targeted therapy against cervical cancer
1 IntroductionTargeted therapy approaches are increasingly implemented in cancer therapy regimens, often complementing con...
Lysate of Parabacteroides distasonis prevents severe forms of experimental autoimmune encephalomyelitis by modulating the priming of T cell response
1 IntroductionMultiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), which is...
Pan-cancer analysis shows that BCAP31 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types
IntroductionThe prevalence and fatality rate of cancer is consistently rising, resulting in cancer being the second most p...
The histamine analogue clobenpropit modulates IRF7 phosphorylation and interferon production by targeting CXCR4 in systemic lupus erythematosus models
IntroductionSystemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a variety of autoantibodie...
Impact of Janus kinase inhibitors and methotrexate on interstitial lung disease in rheumatoid arthritis patients
IntroductionRheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by chronic joint inflammation, a...
Retraction: Autoantibodies in renal diseases – clinical significance and recent developments in serological detection
Retraction: Autoantibodies in renal diseases – clinical significance and recent developments in serological detectionPleas...
C3 deficiency promotes pulmonary inflammation in AT1R-induced mouse model for systemic sclerosis
IntroductionSystemic sclerosis (SSc) is an autoimmune connective tissue disease with multiple organ involvements and heter...
Metformin improves Mycobacterium avium infection by strengthening macrophage antimicrobial functions
IntroductionNon-tuberculous mycobacterial (NTM) infections have emerged as significant public health concerns worldwide du...
Associations of NETs with inflammatory risk and clinical predictive value in large artery atherosclerosis stroke: a prospective cohort study
1 IntroductionIschemic stroke is the major cause of death and disability worldwide (1). The prevalence and the burden of i...
Deciphering ferroptosis in critical care: mechanisms, consequences, and therapeutic opportunities
1 IntroductionCritical illness, marked by organ-level pathophysiological disruptions, remains a significant global health ...
Regulation of epidermal barrier function and pathogenesis of psoriasis by serine protease inhibitors
1 BackgroundSerine protease inhibitors (Serpins) is a new family proposed by Hunt et al. (1, 2) in 1980 on the basis of th...
The immune mechanisms of acute exacerbations of idiopathic pulmonary fibrosis
A brief introductionIdiopathic pulmonary fibrosis (IPF) is an interstitial lung disease (ILD) characterized by progressive...
T cell metabolism in kidney immune homeostasis
Highlights● The metabolism of T cells mediates their functions through both metabolic and epigenetic mechanisms.● T cells ...
Angiogenesis and EMT regulators in the tumor microenvironment in lung cancer and immunotherapy
1 BackgroundLung cancer ranks as the second most prevalent cancer globally, leading in incidence among men and following b...
Clinical characteristics and prognostic factors of COVID-19 in rheumatic patients and their family members: a retrospective study
1 IntroductionThe Corona Virus Disease 2019 (COVID-19) is an acute respiratory infectious disease caused by the SARS-CoV-2...
Fexuprazan safeguards the esophagus from hydrochloric acid-induced damage by suppressing NLRP1/Caspase-1/GSDMD pyroptotic pathway
1 IntroductionGastric acid secretion inhibitors play a pivotal role as a primary treatment modality for acid-related gastr...
Case report: paraneoplastic cerebellar degeneration associated with anti-Yo antibody successfully treated with ofatumumab
1 IntroductionParaneoplastic cerebellar degeneration (PCD) is a rare immune-mediated disorder with a strong association wi...
Impaired interhemispheric synchrony in patients with iridocyclitis and classification using machine learning: an fMRI study
IntroductionUveitis, a prevalent inflammatory ocular disease that poses a significant risk to vision, is reported to have ...
Enabling immune checkpoint blockade efficacy in T-lymphopenia by restoring CD8 T cell dynamics with IL-7 cytokine therapy
1 IntroductionImmune checkpoint blockades (ICB), such as anti-programmed cell death-1 (PD-1) and anti-programmed death lig...
AKR1B10 and digestive tumors development: a review
1 IntroductionAKR1B10 is an NADPH-dependent reductase belonging to subfamily 1B of the aldo-keto reductases (AKRs). It was...
Circulating levels of cytokines and risk of inflammatory bowel disease: evidence from genetic data
Circulating levels of cytokines and risk of inflammatory bowel disease: evidence from genetic data
BackgroundPrior epidemiological studies have established a correlation between inflammatory cytokines and inflammatory bow...
Unraveling the enigma of B cells in diffuse large B-cell lymphoma: unveiling cancer stem cell-like B cell subpopulation at single-cell resolution
Unraveling the enigma of B cells in diffuse large B-cell lymphoma: unveiling cancer stem cell-like B cell subpopulation at single-cell resolution
BackgroundDiffuse large B-cell lymphoma (DLBCL) represents the most prevalent form of aggressive non-Hodgkin lymphoma. Des...
The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation
The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation
IntroductionThe killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, f...
Simulating immunosuppressive mechanism of Microplitis bicoloratus bracovirus coordinately fights Spodoptera frugiperda
Simulating immunosuppressive mechanism of Microplitis bicoloratus bracovirus coordinately fights Spodoptera frugiperda
Parasitoid wasps control pests via a precise attack leading to the death of the pest. However, parasitoid larvae exhibit s...
ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
IntroductionExtracorporal Photophoresis (ECP) is in clinical use for steroid-refractory and steroid-dependent acute GVHD (...
Pathological granuloma fibrosis induced by agar-embedded Mycobacterium abscessus in C57BL/6JNarl mice
Pathological granuloma fibrosis induced by agar-embedded Mycobacterium abscessus in C57BL/6JNarl mice
IntroductionPulmonary granuloma diseases caused by Mycobacterium abscessus (M. abscessus) have increased in past decades, ...
Inducing enhanced neutralizing antibodies against broad SARS-CoV-2 variants through glycan-shielding multiple non-neutralizing epitopes of RBD
Inducing enhanced neutralizing antibodies against broad SARS-CoV-2 variants through glycan-shielding multiple non-neutralizing epitopes of RBD
IntroductionSince the outbreak of SARS-CoV-2, vaccines have demonstrated their effectiveness in resisting virus infection,...
Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis
Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis
TNF-α is essential for induction and maintenance of inflammatory responses and its dysregulation is associated with suscep...
Deciphering the human antibody response against Burkholderia pseudomallei during melioidosis using a comprehensive immunoproteome approach
Deciphering the human antibody response against Burkholderia pseudomallei during melioidosis using a comprehensive immunoproteome approach
IntroductionThe environmental bacterium Burkholderia pseudomallei causes the often fatal and massively underreported infec...
Recombinant antigen P29 of Echinococcus granulosus induces Th1, Tc1, and Th17 cell immune responses in sheep
Recombinant antigen P29 of Echinococcus granulosus induces Th1, Tc1, and Th17 cell immune responses in sheep
Echinococcosis is a common human and animal parasitic disease that seriously endangers human health and animal husbandry. ...
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