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An inter-organ neuro–immuno–endocrine circuit for glucose homeostasis
A study in Science reports that intestinal innate lymphoid cells migrate to the pancreas in response to low blood glucose ...
Kidney immunology from pathophysiology to clinical translation
Kidney immunology from pathophysiology to clinical translation
Kidney diseases are widespread and represent a considerable medical, social and economic burden. However, there has been m...
Podoplanin mediates stromal–immune crosstalk in the lymph node
A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in l...
Immune control of brain physiology
Immune control of brain physiology
The peripheral immune system communicates with the brain through complex anatomical routes involving the skull, the brain ...
Trained immunity in chronic inflammatory diseases and cancer
Trained immunity in chronic inflammatory diseases and cancer
A decade after the term ‘trained immunity’ (TRIM) was coined to reflect the long-lasting hyper-responsiveness ...
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors
A recent Review in this journal by Comerford and McColl1 discussed how atypical chemokine receptors (ACKRs) have emerged a...
B cells in non-lymphoid tissues
B cells in non-lymphoid tissues
B cells have long been understood to be drivers of both humoral and cellular immunity. Recent advances underscore this imp...
Faulty mitochondria jump between tumours and T cells
Faulty mitochondria jump between tumours and T cells
To evade elimination by T cells, tumour cells transfer mutant mitochondria to T cells, which reprogrammes their metabolism...
Sleep deprivation whips up cytokine storm
A new mouse model of sleep deprivation reveals a potent pathway by which sleep-related changes in prostaglandin D2 in the ...
TCRs and AI: the future is now
A preprint by Fast et al. describes TAPIR, a computational tool for predicting TCR–pMHC interactions.
Adipose tissue maintains healthy joint fibroblasts via cortisol signalling
A preprint by Faust et al. determines mechanisms of crosstalk between adipocytes and fibroblasts in the joint relevant to ...
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
The approval of the first immune checkpoint inhibitors provided a paradigm shift for the treatment of malignancies across ...
Neonatal monocytes suppress adult TH17 cell responses in skin
A preprint by Dhariwala et al. reports that monocytes in the skin of newborn mice suppress microbiota-driven inflammatory ...
Brain regulatory T cells
Brain regulatory T cells
The brain, long thought to be isolated from the peripheral immune system, is increasingly recognized to be integrated into...
Author Correction: Protein kinases: drug targets for immunological disorders
Authors and AffiliationsDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Nationa...
Communicating science effectively in times of crisis: time for reflection
Communicating science effectively in times of crisis: time for reflection
Gary Koretzky served as president of the American Association of Immunologists (AAI) from 2021 to 2022. During this tenure...
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Liver X receptor (LXR) signalling can inhibit the DNA-sensing cGAS–STING inflammatory pathway through degradation of...
Role of the microbiota in response to and recovery from cancer therapy
Role of the microbiota in response to and recovery from cancer therapy
Our understanding of how the microbiota affects the balance between response to and failure of cancer treatment by modulat...
Low serotonin linked to long COVID
Low serotonin linked to long COVID
A study shows that individuals with long COVID have low levels of serotonin, which explains the neurocognitive impairments...
Host IgM facilitates mating in Leishmania
The parasite Leishmania, which causes the debilitating disease leishmaniasis, is spread by sandflies and affects millions ...
Gut fungi have lasting effect on immune response to severe COVID-19
A study by Kusakabe et al. reports increased antibody responses to specific fungi in individuals with severe COVID-19, par...
NMDAR-directed CAAR T cells show promise for autoimmune encephalitis
N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis. It is usually treated by un...
IBEX: a user-friendly and open-source solution for high-plex immunostaining
IBEX: a user-friendly and open-source solution for high-plex immunostaining
In this Tools of the Trade article, Leanne Arakkal (of the Ronald Germain group) describes a technique for highly multiple...
The cancer-immune dialogue in the context of stress
The cancer-immune dialogue in the context of stress
Although there is little direct evidence supporting that stress affects cancer incidence, it does influence the evolution,...
Turning on anti-tumour T cells via MTAP
Chromosomal region 9p21 is the most common homozygously deleted region in cancer and this has been attributed to the loss ...
Protective roles for γδ T cells in inflammatory bowel disease
Here, Dart et al. describe a role for butyrophilin-like (BTNL) molecules in mediating the selection of tissue-protective γ...
Tracking the infant immune response to SARS-CoV-2
This study used a multi-omics approach to assess immune responses in infants and young children before, during and after a...
Daughters forget, mothers remember
Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and ...
Human immune organoids: a tool to study vaccine responses
In this Tools of the Trade article, Lisa Wagar (while in the Mark Davis lab) developed an in vitro immune organoid system ...
The distinctive immune features of long COVID
A large, cross-sectional immune-profiling study provides insights into the biological features of long COVID.
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