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To die or not to die: Gasdermins in intestinal health and disease
To die or not to die: Gasdermins in intestinal health and disease
The first member of the gasdermin family was identified in the upper gastrointestinal tract in 2000 [1]. Up until now, the...
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
AhRAryl hydrocarbon receptorASHalcoholic steatohepatitisACLFacute-on-chronic-liver-failureASBTApical Sodium-dependent BA T...
Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond
Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond
Type I interferons (IFNs) constitute a major antiviral defense system of the body. They were discovered over 60 years ago ...
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Resolving intratumoral B cells and IG-producing plasma cell content is critical for our understanding of tumor-immunity in...
Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy
Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy
Volume 71, February 2024, 101848Author links open overlay panel, AbstractDendritic cells (DCs) are professional antigen-pr...
Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis
Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis
Volume 70, November 2023, 101849Author links open overlay panel, , , AbstractNeutrophils are among the most abundant immun...
Regulatory T cells in allergic inflammation
Regulatory T cells in allergic inflammation
APCsAntigen-presenting cellsAT2Type II alveolar cellsαVβ8alpha-V:beta-8 integrinα4β7Alpha 4 beta 7 integrinCCR6C-C Motif C...
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Volume 70, November 2023, 101845Author links open overlay panel, Highlights•The gasdermin family of proteins are terminal ...
The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions
The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions
KeywordsAllergyAutoimmune diseasesBarrier dysfunctionEpithelitisEpithelial barrier theoryLungsMetabolic diseasesMicrobiota...
The noncanonical inflammasome-induced pyroptosis and septic shock
The noncanonical inflammasome-induced pyroptosis and septic shock
AbbreviationAAK1AP2 Associated Kinase 1AOAHAcyloxyacyl hydrolaseCARDCaspase recruitment and activation domaincGASCyclic GM...
The immunology and cell biology of T cell aging
The immunology and cell biology of T cell aging
Volume 70, November 2023, 101843Author links open overlay panelJörg J. Goronzy, Nan-ping WengShow morePrevious article in ...
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Volume 70, November 2023, 101840Author links open overlay panel, , , AbstractPopulation aging, a pervasive global demograp...
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Vaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, includ...
Better safe than sorry: Naive T-cell dynamics in healthy ageing
Better safe than sorry: Naive T-cell dynamics in healthy ageing
Volume 70, November 2023, 101839Author links open overlay panel, , AbstractIt is well-known that the functioning of the im...
Epigenetic and transcriptional control of gasdermins
Epigenetic and transcriptional control of gasdermins
Cells undergo an inflammatory programmed lytic cell death called ‘pyroptosis’ (with the Greek roots ‘fiery’), often featur...
Proteostasis in T cell aging
Proteostasis in T cell aging
Volume 70, November 2023, 101838Author links open overlay panel, , , AbstractAging leads to a decline in immune cell funct...
Thymus aging and immune reconstitution, progresses and challenges
Thymus aging and immune reconstitution, progresses and challenges
Thymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prom...
The paradox of aging: Aging-related shifts in T cell function and metabolism
The paradox of aging: Aging-related shifts in T cell function and metabolism
Volume 70, November 2023, 101834Author links open overlay panel, , AbstractT cell survival, differentiation after stimulat...
Gasdermins and cancers
Gasdermins and cancers
The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Althou...
T cell control of SARS-CoV-2: When, which, and where?
T cell control of SARS-CoV-2: When, which, and where?
Efficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and...
Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging
Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging
AbbreviationsBAFFB-cell activating factor of the tumor necrosis factor superfamilyBECblood endothelial cellsBMP,bone morph...
Accumulation of immune-suppressive CD4 + T cells in aging – tempering inflammaging at the expense of immunity
Accumulation of immune-suppressive CD4 + T cells in aging – tempering inflammaging at the expense of immunity
AbbreviationsCNScentral nervous systemGRNgene regulatory networkMCMVmouse cytomegalovirusTfh cellsT follicular helper cell...
Enteric neuro-immune interactions in intestinal health and disease
Enteric neuro-immune interactions in intestinal health and disease
AbbreviationsENSEnteric nervous systemIPANsIntrinsic primary afferent neuronsCSF1Colony stimulatory factor 1IFNGR2Interfer...
The role of caspase-8 in inflammatory signalling and pyroptotic cell death
The role of caspase-8 in inflammatory signalling and pyroptotic cell death
RIPK1Receptor-interacting protein kinase 1RIPK3Receptor-interacting protein kinase 3NK cellsNatural killer cellsTNFTumour ...
T cell control of inflammaging
T cell control of inflammaging
Volume 70, November 2023, 101818Author links open overlay panel, , AbstractT cells are a critical component of the immune ...
Aging of lymphoid stromal architecture impacts immune responses
Aging of lymphoid stromal architecture impacts immune responses
Volume 70, November 2023, 101817Author links open overlay panelHighlights•Reduced immune outputs with age coincide with se...
Epithelial inflammasomes, gasdermins, and mucosal inflammation – Lessons from Salmonella and Shigella infected mice
Epithelial inflammasomes, gasdermins, and mucosal inflammation – Lessons from Salmonella and Shigella infected mice
Volume 70, November 2023, 101812Author links open overlay panel, , , AbstractBesides its crucial function in nutrient abso...
Immune aging – A mechanism in autoimmune disease
Volume 69, September 2023, 101814Author links open overlay panel, , , Highlights•Immune ageing is a risk factor for autoim...
Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging
Volume 69, September 2023, 101816Author links open overlay panel, AbstractUnconventional T cells include γδ T cells, invar...
Inflammasomes as regulators of non-infectious disease
Volume 69, September 2023, 101815Author links open overlay panel, AbstractInflammasomes are cytoplasmic organelles that st...
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