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Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease
Alzheimer’s disease is a neurodegenerative condition associated with the accumulation of two misfolded proteins, amy...
The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
Identifying individuals with mild cognitive impairment (MCI) who are likely to progress to Alzheimer’s disease and r...
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
High gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impair...
How healthy participants value additional diagnostic testing with amyloid-PET in patients diagnosed with mild cognitive impairment — a bidding game experiment
How healthy participants value additional diagnostic testing with amyloid-PET in patients diagnosed with mild cognitive impairment — a bidding game experiment
To estimate the perceived value of additional testing with amyloid-PET in Euros in healthy participants acting as analogue...
Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. Howev...
Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
Participant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a funct...
Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories
Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories
Cognitive complaints are often regarded as an early sign of Alzheimer’s disease (AD) but may also occur in several o...
Cross-cultural effects of reminiscence therapy on life satisfaction and autobiographical memory of older adults: a pilot study across Mexico and Spain
Cross-cultural effects of reminiscence therapy on life satisfaction and autobiographical memory of older adults: a pilot study across Mexico and Spain
There are increasing reports on the cognitive and emotional benefits of positive reminiscence therapy in older people. The...
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis
Identification of patients with idiopathic normal pressure hydrocephalus (iNPH) in a collective with suspected neurodegene...
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Progression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumula...
Health-related quality of life in subjective cognitive decline and mild cognitive impairment: a longitudinal cohort analysis
Health-related quality of life in subjective cognitive decline and mild cognitive impairment: a longitudinal cohort analysis
Health-related quality of life (HR-QoL) is an important outcome for patients and crucial for demonstrating the value of ne...
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
The Alzheimer’s disease (AD) risk gene ABCA7 has suggested functions in lipid metabolism and the immune system. Rare...
Distinct effects of cholesterol profile components on amyloid and vascular burdens
Distinct effects of cholesterol profile components on amyloid and vascular burdens
Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships o...
A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults
A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults
Genomic study of cognition decline while considering baseline cognition and lifestyle behaviors is scarce. We aimed to eva...
Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study
Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study
Subjective cognitive complaints (SCC) have been mostly studied in the context of Alzheimer’s disease in memory clini...
Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI
Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI
Understanding the pathological characteristics of various mild cognitive impairment (MCI) subtypes is crucial for the diff...
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up ...
Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial
Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial
In MAPT (Multidomain Alzheimer Preventive Trial), a cognitive effect of multidomain intervention (MI) was showed in non-de...
Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials
Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials
To enable successful inclusion of electroencephalography (EEG) outcome measures in Alzheimer’s disease (AD) clinical...
Correction: Differential response to donepezil in MRI subtypes of mild cognitive impairment
Correction: Differential response to donepezil in MRI subtypes of mild cognitive impairment
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease
Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease
Mild cognitive impairment (MCI) is often considered an early stage of dementia, with estimated rates of progression to dem...
Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status
Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status
Alzheimer’s disease involves accumulating amyloid (A) and tau (T) pathology, and progressive neurodegeneration (N), ...
Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response
Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response
Current treatments for Alzheimer’s disease (AD) have largely failed to yield significant therapeutic benefits. Novel...
Independent effect of Aβ burden on cognitive impairment in patients with small subcortical infarction
Independent effect of Aβ burden on cognitive impairment in patients with small subcortical infarction
The effect of amyloid-β (Aβ) on cognitive impairment in patients with small subcortical infarction remains contr...
Blood biomarkers and neurodegeneration in individuals exposed to repetitive head impacts
Blood biomarkers and neurodegeneration in individuals exposed to repetitive head impacts
It is unknown if fluid biomarkers reflective of brain pathologies are useful in detecting and following a neurodegenerativ...
Biomarkers in Alzheimer’s disease: role in early and differential diagnosis and recognition of atypical variants
Biomarkers in Alzheimer’s disease: role in early and differential diagnosis and recognition of atypical variants
Development of in vivo biomarkers has shifted the diagnosis of Alzheimer’s disease (AD) from the later dementia stag...
Hippocampal injections of soluble amyloid-beta oligomers alter electroencephalographic activity during wake and slow-wave sleep in rats
Hippocampal injections of soluble amyloid-beta oligomers alter electroencephalographic activity during wake and slow-wave sleep in rats
Soluble amyloid-beta oligomers (Aβo) begin to accumulate in the human brain one to two decades before a clinical diag...
Mitochondrial SOS: how mtDNA may act as a stress signal in Alzheimer’s disease
Mitochondrial SOS: how mtDNA may act as a stress signal in Alzheimer’s disease
Alterations in mitochondrial DNA (mtDNA) levels have been observed in Alzheimer’s disease and are an area of researc...
Readthrough isoform of aquaporin-4 (AQP4) as a therapeutic target for Alzheimer’s disease and other proteinopathies
Readthrough isoform of aquaporin-4 (AQP4) as a therapeutic target for Alzheimer’s disease and other proteinopathies
The glymphatic system is a crucial component in preserving brain homeostasis by facilitating waste clearance from the cent...
Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
The first predominant clinical symptoms of dementia with Lewy bodies (DLB) are highly variable; however, the prognosis bas...
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