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Potentially Inappropriate Psychotropic Drugs in Nursing Homes: An Italian Observational Study
Potentially Inappropriate Psychotropic Drugs in Nursing Homes: An Italian Observational Study
Physicians often face difficulties in selecting appropriate medications for older adults with multiple comorbidities. As p...
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations
Though more common earlier in life, increasing attention is being focused on the development of cutaneous lupus erythemato...
A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults
A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults
Older adults are at greater risk of medication-related harm than younger adults. The Integrated Medication Management mode...
Evaluating the Safety of an Educational Deprescribing Intervention: Lessons from the Optimize Trial
Evaluating the Safety of an Educational Deprescribing Intervention: Lessons from the Optimize Trial
Patients, family members, and clinicians express concerns about potential adverse drug withdrawal events (ADWEs) following...
Potentially inappropriate prescribing in multimorbid and polymedicated older adults with AF: A Systematic Review and Meta-Analysis
Potentially inappropriate prescribing in multimorbid and polymedicated older adults with AF: A Systematic Review and Meta-Analysis
Polypharmacy in multimorbid older patients with atrial fibrillation (AF) is a risk factor for potentially inappropriate pr...
Current Pharmacological Therapies for the Management of Spondyloarthritis: Special Considerations in Older Patients
Current Pharmacological Therapies for the Management of Spondyloarthritis: Special Considerations in Older Patients
Spondylarthritis (SpA) is generally observed in young male patients but can be diagnosed in older patients. These cases co...
Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: The GeroCovid Vax Study
Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: The GeroCovid Vax Study
Polypharmacy is common in older adults, particularly among those living in long-term care facilities. This condition repre...
Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross-sectional study
Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross-sectional study
Atrial fibrillation (AF) is a common condition among older adults, requiring anticoagulation therapy to prevent thromboemb...
Factors Associated with Psychotropic Medication Use in People Living with Dementia in the Community: A Systematic Review and Meta-Analysis
Factors Associated with Psychotropic Medication Use in People Living with Dementia in the Community: A Systematic Review and Meta-Analysis
There has been considerable focus on the use of psychotropic agents in people living with dementia in long-term care. Howe...
NSAIDs for Pain Control During the Peri-Operative Period of Hip Fracture Surgery: A Systematic Review
NSAIDs for Pain Control During the Peri-Operative Period of Hip Fracture Surgery: A Systematic Review
Hip fracture (HF) mostly affects older adults and is responsible for increased morbidity and mortality. Non-steroidal anti...
Five-Year Follow-Up of Diabetic Complications and Geriatric Alterations in French Older Patients with Type 2 Diabetes According to Treatment Modalities: The Observational Prospective GERODIAB Cohort
Five-Year Follow-Up of Diabetic Complications and Geriatric Alterations in French Older Patients with Type 2 Diabetes According to Treatment Modalities: The Observational Prospective GERODIAB Cohort
Little is known about clinical events occurring in older patients with type 2 diabetes mellitus according to their therape...
Low-Income Older Adults’ Vulnerability to Anticholinergic Medication-Associated Frailty
Low-Income Older Adults’ Vulnerability to Anticholinergic Medication-Associated Frailty
A growing body of research supports the negative impact of anticholinergic drug burden on physical frailty. However, prior...
Prescribing Cascades with Recommendations to Prevent or Reverse Them: A Systematic Review
Prescribing Cascades with Recommendations to Prevent or Reverse Them: A Systematic Review
To reduce prescribing cascades occurring in clinical practice, healthcare providers require information on the prescribing...
Anti-VEGF Drugs in Age-Related Macular Degeneration: A Focus on Dosing Regimen-Related Safety and Efficacy
Anti-VEGF Drugs in Age-Related Macular Degeneration: A Focus on Dosing Regimen-Related Safety and Efficacy
Age-related macular degeneration (AMD) is one of the main causes of visual impairment and severe visual loss, and can prog...
Prevalence of and Risk Factors for Drug-Related Readmissions in Older Adults: A Systematic Review and Meta-Analysis
Prevalence of and Risk Factors for Drug-Related Readmissions in Older Adults: A Systematic Review and Meta-Analysis
Older adults are at an increased risk of drug-related problems, especially following discharge from hospital. Drug-related...
Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing
Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing
Opioids and benzodiazepines (BZDs) pose a public health problem. Older adults are especially susceptible to adverse events...
The PROMISING Project: A Pilot Study to Improve Geriatric Care Through a Pharmacist-Led Psychotropic Stewardship Program
The PROMISING Project: A Pilot Study to Improve Geriatric Care Through a Pharmacist-Led Psychotropic Stewardship Program
Psychotropic medications are frequently prescribed during acute care, even in older patients. They represent a risk for in...
Crushed Tablet Administration for Patients with Dysphagia and Enteral Feeding: Challenges and Considerations
Crushed Tablet Administration for Patients with Dysphagia and Enteral Feeding: Challenges and Considerations
Dysphagia is increasingly common in older adults; it is especially prevalent in long-term care settings. Patients with dys...
Systematic Review and Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults: An Update
Systematic Review and Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults: An Update
We previously reported that interventions to optimize medication use reduced adverse drug reactions (ADRs) by 21% and seri...
Secular Trends in Central Nervous System-Active Polypharmacy Among Serial Cross-Sections of US Adults, 2009–2020
Secular Trends in Central Nervous System-Active Polypharmacy Among Serial Cross-Sections of US Adults, 2009–2020
Data comprehensively examining trends in central nervous system (CNS)-active polypharmacy are limited. The objective of th...
Psychiatric Adverse Events of Acetylcholinesterase Inhibitors in Alzheimer’s Disease and Parkinson’s Dementia: Systematic Review and Meta-Analysis
Psychiatric Adverse Events of Acetylcholinesterase Inhibitors in Alzheimer’s Disease and Parkinson’s Dementia: Systematic Review and Meta-Analysis
The acetylcholinesterase inhibitors (AChEIs) donepezil, galantamine, and rivastigmine are commonly used in the management ...
The Impact of Polypharmacy on Management of Lower Urinary Tract Symptoms in Parkinson’s Disease
The Impact of Polypharmacy on Management of Lower Urinary Tract Symptoms in Parkinson’s Disease
Lower urinary tract (LUT) symptoms are a common presentation of autonomic dysfunction in Parkinson’s disease (PD). S...
Methodological Considerations for Describing Medication Changes in Relation to Clinical Events and Death: An Applied Example in Patients with Type 2 Diabetes and Cancer
Methodological Considerations for Describing Medication Changes in Relation to Clinical Events and Death: An Applied Example in Patients with Type 2 Diabetes and Cancer
Certain clinical events reduce life expectancy and necessitate a reassessment of patient treatment. To describe medication...
Anticholinergic Burden and Cognitive Impairment in Nursing Homes: A Comparison of Four Anticholinergic Scales
Anticholinergic Burden and Cognitive Impairment in Nursing Homes: A Comparison of Four Anticholinergic Scales
Medications with anticholinergic effects are commonly used in nursing homes, and their cumulative effect is of particular ...
Discontinuation of Loop Diuretics in Older Patients with Chronic Stable Heart Failure: A Narrative Review
Discontinuation of Loop Diuretics in Older Patients with Chronic Stable Heart Failure: A Narrative Review
Loop diuretics (LDs) represent the cornerstone treatment for relieving pulmonary congestion in patients with heart failure...
Efficacy and Safety of Dupilumab in Older Patients (Aged 80 Years and Above) with Atopic Dermatitis: A Prospective Study
Efficacy and Safety of Dupilumab in Older Patients (Aged 80 Years and Above) with Atopic Dermatitis: A Prospective Study
Atopic dermatitis presents unique challenges in the older population owing to age-related changes in skin barrier function...
Theoretical Underpinnings of a Model to Reduce Polypharmacy and Its Negative Health Effects: Introducing the Team Approach to Polypharmacy Evaluation and Reduction (TAPER)
Theoretical Underpinnings of a Model to Reduce Polypharmacy and Its Negative Health Effects: Introducing the Team Approach to Polypharmacy Evaluation and Reduction (TAPER)
Polypharmacy, particularly among older adults, is gaining recognition as an important risk to health. The harmful effects ...
Hypertension Treatment in Frail Older Adults: A Systematic Review and Appraisal of Guidelines
Hypertension Treatment in Frail Older Adults: A Systematic Review and Appraisal of Guidelines
Managing hypertension in frail older patients is challenging. Several institutions and organizations have published up-to-...
A Review of Therapeutics for Treatment-Resistant Depression in the Older Adult
A Review of Therapeutics for Treatment-Resistant Depression in the Older Adult
One-third of older adults with depression meet criteria for treatment resistance, typically defined as a lack of response ...
Evaluation and Treatment of Acute Trauma Pain in Older Adults
Evaluation and Treatment of Acute Trauma Pain in Older Adults
In the context of an ageing population, the demographic sands of trauma are shifting. Increasingly, trauma units are servi...
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