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Organic cation transporters in psychiatric and substance use disorders
Organic cation transporters in psychiatric and substance use disorders
Psychiatric and substance use disorders pose significant public health burdens across the globe. An estimated 970 million ...
Clinical advances in TNC delivery vectors and their conjugate agents
Clinical advances in TNC delivery vectors and their conjugate agents
Tenascin C (TNC), a glycoprotein that is abundant in the tumor extracellular matrix (ECM), is strongly overexpressed in tu...
Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases
Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases
Available online 7 December 2023, 108576Author links open overlay panel, , , , , , , , , , AbstractRNA ac4C modification i...
Hypertension & dementia: Pathophysiology & potential utility of antihypertensives in reducing disease burden
Hypertension & dementia: Pathophysiology & potential utility of antihypertensives in reducing disease burden
Dementia is a progressive neurodegenerative disease that develops most commonly in late adulthood and is predominantly cha...
Repurposing of pexidartinib for microglia depletion and renewal
Repurposing of pexidartinib for microglia depletion and renewal
Available online 3 December 2023, 108565Author links open overlay panel, , , AbstractPexidartinib (PLX3397) is a small mol...
Retracing our steps: A review on autism research in children, its limitation and impending pharmacological interventions
Retracing our steps: A review on autism research in children, its limitation and impending pharmacological interventions
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by three core impairments: impaired communic...
Therapeutic potential of stem cells in regeneration of liver in chronic liver diseases: Current perspectives and future challenges
Therapeutic potential of stem cells in regeneration of liver in chronic liver diseases: Current perspectives and future challenges
Chronic liver diseases (CLDs) are the leading cause of liver-related fatalities, accounting for 2 million deaths yearly (D...
Emerging role of immune cells as drivers of pulmonary fibrosis
Emerging role of immune cells as drivers of pulmonary fibrosis
Pulmonary fibrosis is an irreversible condition where the tissue (interstitium) surrounding the small air sacs (alveoli) i...
Retinoid X receptor agonists as selective modulators of the immune system for the treatment of cancer
Retinoid X receptor agonists as selective modulators of the immune system for the treatment of cancer
Retinoid X receptors (RXRs) are essential modulators of human physiology and attractive targets for treating cancer (Altuc...
What matters in aging is signaling for responsiveness
What matters in aging is signaling for responsiveness
Aging has traditionally been viewed as a multifaceted process influenced by various factors, including genetics, environme...
From exploring cancer and virus targets to discovering active peptides through mRNA display
From exploring cancer and virus targets to discovering active peptides through mRNA display
At first glance, cancer and viral infections have nothing in common – and, indeed, the differences run deep. However, from...
Multitarget antibacterial drugs: An effective strategy to combat bacterial resistance
Multitarget antibacterial drugs: An effective strategy to combat bacterial resistance
Antibiotic resistance has become a global health crisis. Antibiotics are undoubtedly indispensable in the fight against ba...
Biologics for severe asthma and beyond
Biologics for severe asthma and beyond
Asthma remains a very common chronic disease worldwide and poses a huge burden on individuals and societies (García-Marcos...
Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?
Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?
AGBadjustable gastric bandingAgRPagouti-related peptideATMadipose tissue macrophagesATPadenosine triphosphateBAIBAβ-aminoi...
NLRP3 and cancer: Pathogenesis and therapeutic opportunities
NLRP3 and cancer: Pathogenesis and therapeutic opportunities
In 2010 we published a provocative review entitled “Why not treat human cancer with interleukin-1 blockade?” and suggested...
Boron in cancer therapeutics: An overview
Boron in cancer therapeutics: An overview
Boron has gradually resurfaced for its medical importance after several studies proved its nutrient value and medicinal pr...
Severe hypertriglyceridemia: Existing and emerging therapies
Severe hypertriglyceridemia: Existing and emerging therapies
Severe hypertriglyceridemia (sHTG) has been arbitrarily defined by different national guidelines as either triglyceride (T...
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities
Epigenetic regulation encompasses the engagement of adaptive cellular pathways influenced by environmental factors and met...
Neuropathic pain: From actual pharmacological treatments to new therapeutic horizons
Neuropathic pain: From actual pharmacological treatments to new therapeutic horizons
Chronic pain is defined as any type of pain that persists more than three months following the initial triggering event (S...
Signaling pathways in brain ischemia: Mechanisms and therapeutic implications
Signaling pathways in brain ischemia: Mechanisms and therapeutic implications
Ischemic stroke refers to blood supply disorders that result in cerebral ischemia and hypoxia and ultimately lead to ische...
Presynaptic glutamate receptors in nociception
Presynaptic glutamate receptors in nociception
Acute, physiological pain serves as an important warning signal in our body to avoid dangerous stimuli or environment, man...
Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases
Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases
Sulfoconjugation, also known as sulfation, is a prevalent cellular reaction that extensively modifies various exogenous co...
Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease
Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease
Wilson's disease is an autosomal recessive disorder with an occurrence of approximately 1:30,000 (Sandahl et al., 2020), a...
Glyoxalase I is a novel target for the prevention of metabolic derangement
Glyoxalase I is a novel target for the prevention of metabolic derangement
Available online 16 September 2023, 108524Author links open overlay panel, AbstractObesity prevalence in the US has nearly...
Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators
Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators
The adrenal cortex produces glucocorticoids (GCs), such as cortisol in humans and corticosterone in rodents. These hormone...
Towards precision medicine in migraine: Recent therapeutic advances and potential biomarkers to understand heterogeneity and treatment response
Towards precision medicine in migraine: Recent therapeutic advances and potential biomarkers to understand heterogeneity and treatment response
5-HT1B/Dserotonin 1B and 1DA1/A2Aadenosine receptorsASICacid-sensing ion channelsBKCalarge conductance calcium-activated p...
Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases
Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases
Our body’s response to an injury ensues a cascade of overlapping healing phases leading to partial restoration of tissue a...
Use of big data and machine learning algorithms to extract possible treatment targets in neurodevelopmental disorders
Use of big data and machine learning algorithms to extract possible treatment targets in neurodevelopmental disorders
Psychiatric disorders affect 20–25% of the population in any given year (Vos et al., 2017) and >50% of the general popu...
Medulloblastoma targeted therapy: From signaling pathways heterogeneity and current treatment dilemma to the recent advances in development of therapeutic strategies
Medulloblastoma targeted therapy: From signaling pathways heterogeneity and current treatment dilemma to the recent advances in development of therapeutic strategies
Medulloblastoma (MB) is a high-risk pediatric brain tumor leading cause of childhood cancer-related deaths, accounting for...
Target protein degradation by protacs: A budding cancer treatment strategy
Target protein degradation by protacs: A budding cancer treatment strategy
Cancer is the prominent cause of death due to its uncontrolled growth of cells (Kaur et al., 2022; Lang, Sood, Kaur, Arora...
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