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Degrading aurora kinase A in neuroblastoma
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Designing proteins targeting neosurfaces
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The multiple myeloma drug market
The multiple myeloma drug market
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PKC modulator promotes remyelination
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New target to tackle coronaviruses
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Novel strategies to manage CAR-T cell toxicity
Novel strategies to manage CAR-T cell toxicity
The immune-related adverse events associated with chimeric antigen receptor (CAR)-T cell therapy result in substa...
Voltage-gated sodium channels in excitable cells as drug targets
Voltage-gated sodium channels in excitable cells as drug targets
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densiti...
Peptide blocks phase separation and oncogenic transcription
Peptide blocks phase separation and oncogenic transcription
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Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Quantitative structure–activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is wide...
Extracellular targeted protein degradation: an emerging modality for drug discovery
Extracellular targeted protein degradation: an emerging modality for drug discovery
Targeted protein degradation (TPD) has emerged in the past decade as a major new drug modality to remove intracellular pro...
Top product forecasts for 2024
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Upcoming market catalysts in Q1 2024
Upcoming market catalysts in Q1 2024
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FDA approves first chikungunya vaccine
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PROTAC in clinic for autoimmune skin disease
PROTAC in clinic for autoimmune skin disease
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Gene therapy zeroes in on Parkinson disease brain circuits
Gene therapy zeroes in on Parkinson disease brain circuits
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FDA approves first-in-class AKT inhibitor
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A decade of HCV drugs
A decade of HCV drugs
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Antibodies achieve leptin balancing act
Antibodies achieve leptin balancing act
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γ-secretase inhibitor notches first approval
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De-risking rare disease acquisitions: a win–win–win for patients, biotech and investors
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tRNA therapeutics for genetic diseases
tRNA therapeutics for genetic diseases
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their therapeutic potential for the t...
CAAR T cells to treat encephalitis
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A safer polyene antifungal
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USP30 inhibition protects dopaminergic neurons
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Open-science drug discovery for COVID-19
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Antibodies combat Gram-negative pathogen
Antibodies combat Gram-negative pathogen
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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Diseases associated with chronic inflammation constitute a major health burden across the world. As central instigators of...
Tailor made: the art of therapeutic mRNA design
Tailor made: the art of therapeutic mRNA design
mRNA medicine is a new and rapidly developing field in which the delivery of genetic information in the form of mRNA is us...
A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics
Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA a...
The renal cell carcinoma drug market
The renal cell carcinoma drug market
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